Publications by authors named "Minako Masuda"
Infect Immun
February 2002
Article Synopsis
- Bordetella dermonecrotic toxin (DNT) activates the small GTPase Rho through processes like deamidation and polyamination, and this study investigates its effects on Rac and Cdc42, other members of the Rho family.
- Immunoprecipitation and immunoblot assays confirm that DNT modifies Rac and Cdc42, leading to a loss of their GTP-hydrolyzing activity while maintaining GTP-binding capabilities.
- Treated MC3T3-E1 cells exhibited significant lamellipodia and filopodia formation, indicating the intracellular activation of Rac and Cdc42 due to DNT exposure.
