Publications by authors named "Minako Kaga"
Article Synopsis
- The JFH-1 strain of hepatitis C virus (HCV) can replicate on its own in certain liver cells, while the J6 strain cannot without modification.
- Researchers created hybrid RNA combinations of J6 and JFH-1 to study which parts enable replication and infectious particle production.
- They found that two specific regions from the JFH-1 strain, NS3 helicase and NS5B-to-3'X, are essential for effective replication and the creation of infectious HCV particles in genotype 2a strains.
Huh7 cells constitute a permissive cell line for cell culture of hepatitis C virus (HCV) particles. However, our Huh7 line shows limited permissiveness for HCV. Thus, in this study we set out to determine which host factors are important for conferring permissiveness.
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