Vortioxetine in the Treatment of Major Depressive Disorder Among Working Patients in Routine Clinical Practice: An Analysis of a Post-Marketing Surveillance Study in South Korea.

Background: Patients with major depressive disorder (MDD) experience depressive symptoms such as anhedonia as well as cognitive dysfunction which can subsequently impair their work performance.

Purpose: To assess the effectiveness and safety of vortioxetine in working patients with MDD in South Korea.

Patients And Methods: This was a subgroup analysis of a prospective, multicenter, non-interventional, non-comparative post-marketing surveillance (PMS) study.

Changes in Technology Acceptance of Smart Care Beds Among Long-Term Care Workers in Korea.

Objectives: This study investigates the changing perceptions of Korean care workers regarding a robotic bed designed to assist with repositioning and prevent pressure ulcers. With the primary aim of assessing the technology acceptance among care workers using the robotic bed to solve the problem of a shortage of care workers in Korea, we sought to examine the possibility of applying care robots in the field.

Methods: A total of 20 long-term care workers participated in the experiment, and their attitudes were measured before and after using the robot.

Thermal runaway prevention through scalable fabrication of safety reinforced layer in practical Li-ion batteries.

Integrating safety features to cut off excessive current during accidental internal short circuits in Li-ion batteries (LIBs) can reduce the risk of thermal runaway. However, making this concept practical requires overcoming challenges in both material development and scalable manufacturing. Here, we demonstrate the roll-to-roll production of a safety reinforced layer (SRL) on current collectors at a rate of 5 km per day.

A smart device application for acute pain service in surgical patients at a tertiary hospital in South Korea: a prospective observational feasibility study.

Background: Pain assessment and patient education are essential for successful postoperative pain management. However, the provision of personnel for performing these tasks is often insufficient. Recently, attempts have been made to implement smartphone applications for educating and monitoring surgical patients.

Career Disruption and Employment Status of Korean Family Caregivers of Older Adults Using Home-Based Care.

This study utilized nationally approved data from the 2022 Long-Term Care Survey of Korea to examine the factors associated with career disruptions and employment status among family caregivers of home-based care recipients. Descriptive statistics, chi-square tests, one-way ANOVA, and multinomial logistic regression analysis were employed to address the research questions. The results indicated that 19.

Bilayer Interphase for Air-Stable and Dendrite-Free Lithium Metal Anode Cycling in Carbonate Electrolytes.

The intrinsic reactivity of lithium (Li) toward ambient air, combined with insufficient cycling stability in conventional electrolytes, hinders the practical adoption of Li metal anodes in rechargeable batteries. Here, a bilayer interphase for Li metal is introduced to address both its susceptibility to corrosion in ambient air and its deterioration during cycling in carbonate electrolytes. Initially, the Li metal anode is coated with a conformal bottom layer of polysiloxane bearing methacrylate, followed by further grafting with poly(vinyl ethylene carbonate) (PVEC) to enhance anti-corrosion capability and electrochemical stability.

An exploratory clinical trial of preoperative non-invasive localization before breast-conserving surgery using augmented reality technology.

Purpose: This single-center, randomized, prospective, exploratory clinical trial was conducted to assess the clinical efficacy of an augmented reality (AR)-based breast cancer localization imaging solution for patients with breast cancer.

Methods: This clinical trial enrolled 20 women who were diagnosed with invasive breast cancer between the ages of 19 and 80, had a single lesion with a diameter ≥ 5 mm but ≤ 30 mm, had no metastases to other organs, and had not received prior chemotherapy. All patients underwent mammography, ultrasound, computed tomography, and magnetic resonance imaging for preoperative assessment.

Solution-Based Deep Prelithiation for Lithium-Ion Capacitors with High Energy Density.

Lithium-ion capacitors (LICs) exhibit superior power density and cyclability compared to lithium-ion batteries. However, the low initial Coulombic efficiency (ICE) of amorphous carbon anodes (e.g.

Immune Checkpoint-Blocking Nanocages Cross the Blood-Brain Barrier and Impede Brain Tumor Growth.

Glioblastoma (GBM) is the deadliest tumor of the central nervous system, with a median survival of less than 15 months. Despite many trials, immune checkpoint-blocking (ICB) therapies using monoclonal antibodies against the PD-1/PD-L1 axis have demonstrated only limited benefits for GBM patients. Currently, the main hurdles in brain tumor therapy include limited drug delivery across the blood-brain barrier (BBB) and the profoundly immune-suppressive microenvironment of GBM.

Double jeopardy: Exploring the moderating effect of educational mismatch in the relationship between work-family conflict and depressive symptoms among Korean working women.

Rationale: Despite a growing body of empirical evidence on the detrimental effects of work-family conflict (WFC) on psychological health, little attention has been given to whether educational mismatch in the workplace, which refers to the perceived level of match between one's attained education and the required educational level for a position, may exacerbate these effects.

Objective: The purpose of this study was to examine the relationship between WFC, educational mismatch, and depressive symptoms in Korean working women, with a particular focus on the potential moderating effects of educational mismatch on the association between WFC and depressive symptoms.

Methods: The data utilized for this study were collected from 5174 married working women over five waves (16,610 person-observations) of the Korean Longitudinal Survey of Women and Families spanning 8 years between 2012 and 2020.

Learnability of Thyroid Nodule Assessment on Ultrasonography: Using a Big Data Set.

Objective: The aims of the work described here were to evaluate the learnability of thyroid nodule assessment on ultrasonography (US) using a big data set of US images and to evaluate the diagnostic utilities of artificial intelligence computer-aided diagnosis (AI-CAD) used by readers with varying experience to differentiate benign and malignant thyroid nodules.

Methods: Six college freshmen independently studied the "learning set" composed of images of 13,560 thyroid nodules, and their diagnostic performance was evaluated after their daily learning sessions using the "test set" composed of images of 282 thyroid nodules. The diagnostic performance of two residents and an experienced radiologist was evaluated using the same "test set.

Is living alone beneficial to older adults during the COVID-19 pandemic? Examining associations between living arrangements and life satisfaction by gender in Korea.

Objectives: This study examines associations between living arrangements and life satisfaction and the associated effects of gender among Korean older adults during the pandemic.

Method: Data were drawn from the 2020 National Survey of Older Koreans-a nationally representative survey. Living arrangements were categorized into four groups: living alone; living with spouse only; living with family and spouse; and living with family without spouse.

Reversible Magnesium Metal Cycling in Additive-Free Simple Salt Electrolytes Enabled by Spontaneous Chemical Activation.

Rechargeable magnesium (Mg) batteries can offer higher volumetric energy densities and be safer than their conventional counterparts, lithium-ion batteries. However, their practical implementation is impeded due to the passivation of the Mg metal anode or the severe corrosion of the cell parts in conventional electrolyte systems. Here, we present a chemical activation strategy to facilitate the Mg deposition/stripping process in additive-free simple salt electrolytes.

Does having children matter? Associations between transitions in work-family role combinations and depressive symptoms among married women in Korea.

Although having a variety of roles is generally beneficial for mental health, little is known about the relationships between work-family role combinations and depressive symptoms among married women in Korea, where child rearing is strongly considered a mother's responsibility. This study examines how the four types of work-family role combinations may be associated with depressive symptoms among married Korean women younger than 50 years old. Data were collected from 2012 through 2020 in five surveys by the Korean Longitudinal Survey of Women & Families.

Relationship between Experience of Client Violence and Turnover Intention among Workers in Long-Term Care Facilities for Older Adults: Focusing on Nurses, Social Workers, and Care Workers.

To prevent discontinuity of long-term care service and guarantee the quality of care, it is important to clarify the determinants of turnover intentions of long-term care workers. They are at a higher risk of experiencing violence-including physical, emotional, and sexual-from patients or their families, possibly leading to high turnover intention. This study aims to verify how having experienced client violence affect turnover intention of long-term care workers and to suggest implications to prevent frequent turnover in long-term care field.

Safety and effectiveness of vortioxetine for major depressive disorder: Real-world evidence from a population-based study in South Korea.

Background: A post-marketing surveillance study was conducted to assess the real-world safety and effectiveness of vortioxetine for the treatment of major depressive disorder (MDD) in South Korea.

Methods: Adult patients aged 19-94 years receiving vortioxetine for MDD at 72 hospitals and clinics in South Korea between 19 August 2014 and 18 August 2020 were included. Patients were followed for up to 24±2 weeks, at up to three visits.

In Situ Mesopore Formation in SiO Nanoparticles by Chemically Reinforced Heterointerface and Use of Chemical Prelithiation for Highly Reversible Lithium-Ion Battery Anode.

SiO is a promising next-generation anode material for lithium-ion batteries. However, its commercial adoption faces challenges such as low electrical conductivity, large volume expansion during cycling, and low initial Coulombic efficiency. Herein, to overcome these limitations, an eco-friendly in situ methodology for synthesizing carbon-containing mesoporous SiO nanoparticles wrapped in another carbon layers is developed.

I Am Not Supposed to Be Treated Like This: Associations Between Age Discrimination, Perceived Social Respect for Older Adults, and Depressive Symptoms in Korean Older Adults.

Objectives: This study examines the relationships between age discrimination, perceived social respect for older adults as a proxy of perceived social climate, and depressive symptoms in older adults in Korea. In doing so, it clarifies whether and how age discrimination has a differential effect on mental health, depending on the level of perceived social respect.

Methods: This study uses multiple regression analyses to examine the data obtained from the 2020 National Survey of Older Koreans, a nationally representative survey.

The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB.

We previously showed that the matricellular protein CCN5 reverses established cardiac fibrosis (CF) through inducing apoptosis in myofibroblasts (MyoFBs) but not in cardiomyocytes or fibroblasts (FBs). In this study, we set out to elucidate the molecular mechanisms underlying CCN5-mediated selective apoptosis of MyoFBs. We first observed that the apoptotic protein p53 and the anti-apoptotic protein NFκB are simultaneously induced in MyoFBs.

Sarcopenia increases the risk of major organ or vessel invasion in patients with papillary thyroid cancer.

While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear. To investigate the impact of sarcopenia on aggressive clinicopathologic features in PTC patients, prospectively collected data on 305 patients who underwent surgery for PTC with preoperative staging ultrasonography and bioelectrical impedance analysis were retrospectively analyzed. Nine sarcopenia patients with preoperative sarcopenia showed more patients aged 55 or older (p = 0.

Cancer yield and imaging features of probably benign calcifications at digital magnification view.

Objectives: To investigate the malignancy rate of probably benign calcifications assessed by digital magnification view and imaging and clinical features associated with malignancy.

Methods: This retrospective study included consecutive women with digital magnification views assessed as probably benign for calcifications without other associated mammographic findings from March 2009 to January 2014. Initial studies rendering a probably benign assessment were analyzed, with biopsy or 4-year imaging follow-up.

Using ultrasonographic features to predict the outcomes of patients with small papillary thyroid carcinomas: a retrospective study implementing the 2015 ATA patterns and ACR TI-RADS categories.

Background: The aim of this study was to evaluate whether risk stratification systems using ultrasonographic (US) features show associations with the outcomes of patients with small papillary thyroid carcinomas (PTCs).

Methods: This retrospective study received institutional review board approval. From March 2007 to February 2010, 775 patients who underwent surgery for small PTCs (10-20 mm) were included.

Weakly Solvating Solution Enables Chemical Prelithiation of Graphite-SiO Anodes for High-Energy Li-Ion Batteries.

Although often overlooked in anode research, the anode's initial Coulombic efficiency (ICE) is a crucial factor dictating the energy density of a practical Li-ion battery. For next-generation anodes, a blend of graphite and Si/SiO represents the most practical way to balance capacity and cycle life, but its low ICE limits its commercial viability. Here, we develop a chemical prelithiation method to maximize the ICE of the blend anodes using a reductive Li-arene complex solution of regulated solvation power, which enables a full cell to exhibit a near-ideal energy density.

Digital technology use and depressive symptoms among older adults in Korea: beneficial for those who have fewer social interactions?

Objectives: Our study examines the relationship between digital technology use and depressive symptoms among older Koreans and whether social interaction moderates the relationship.

Methods: The data were drawn from the 2017 Survey of Living Conditions and Welfare Needs of Korean Older Persons, a nationally representative survey. Digital technology use was measured by the number of digital functions that respondents perform with their electronic devices.