Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Extract.

JNK and p38 are important mitogen-activated protein kinases (MAPKs) that respond to stress stimuli. The stress-activated MAPKs associated with apoptotic cell death play vital roles in mammalian cells. , which contains abundant diarylheptanoids derivatives, is a valuable medicinal plant.

Severe hepatotoxicity associated with the dietary supplement LipoKinetix.

Background: LipoKinetix (Syntrax, Cape Girardeau, Missouri) is a dietary supplement marketed for weight loss.

Objective: To describe a possible causal association between LipoKinetix and hepatotoxicity.

Design: Case series.