Publications by authors named "Mina Kono"
Background: Urinary tract infections (UTIs) are the most common bacterial infections in children. This study aimed to review characteristics of causative bacteria and the effectiveness of antimicrobial therapy in children with febrile UTIs.
Methods: Clinical records of 108 patients (130 episodes) with febrile UTIs admitted to the Kawasaki Medical School Hospital between July 2009 and October 2016 were retrospectively reviewed.
Article Synopsis
- Mycoplasma pneumoniae is a leading cause of pneumonia in children and young adults, prompting a study on its prevalence in Japanese children since 2008.
- The study used nasopharyngeal swabs and real-time PCR to identify infections and analyze p1 genotypes.
- Findings showed a peak in macrolide-resistant M. pneumoniae infections in 2012, followed by varying rates of resistance and genotype changes through 2018, suggesting that both antibiotic use and genotype distribution influenced resistance levels.
Article Synopsis
- A national survey in Japan from June 2008 to March 2018 examined children (0-15 years) for Chlamydia pneumoniae and Mycoplasma pneumoniae infections during an epidemic season for M. pneumoniae.
- Out of 5002 nasopharyngeal swab samples tested, 36.5% were positive for M. pneumoniae, while only 0.8% were positive for C. pneumoniae, indicating a much lower prevalence for the latter.
- The study concluded that C. pneumoniae infections were rare compared to M. pneumoniae, and children with single C. pneumoniae infections likely had active infections, unlike those with coinfections who were more likely carriers.
We compared the antimicrobial susceptibility of isolates from pediatric patients in Japan in 2011-2012 and 2015-2016, when epidemics occurred. The antimicrobial activity of macrolides and tetracyclines against infection tended to be restored in 2015-2016. There was no change in the antimicrobial activity of quinolones against infection.
View Article and Find Full Text PDFIncidence of Viremia With DNA Viruses in Oncology Patients With Febrile Neutropenia.
J Pediatr Hematol Oncol
November 2018
Background: Although febrile neutropenia (FN) is one of the most common adverse events produced by chemotherapy, its microbiological etiology is determined for only 15% to 30% of cases.
Objectives: We investigated the rate of viremia with common DNA viruses in patients with FN.
Study Design: From June 2012 to April 2014, 72 blood samples from 24 patients receiving chemotherapy, who experienced FN episodes, were examined for the presence of herpes viruses and other DNA viruses.
Macrolide-Resistant Mycoplasma pneumoniae Infection, Japan, 2008-2015.
Emerg Infect Dis
October 2017
We evaluated isolates obtained from children with Mycoplasma pneumoniae infection throughout Japan during 2008-2015. The highest prevalence of macrolide-resistant M. pneumoniae was 81.
View Article and Find Full Text PDFObjective: The efficacy of ramelteon, a sleep agent thought to induce natural sleep through its actions on the melatonin receptors 1 and 2, was evaluated during electroencephalography (EEG).
Methods: We retrospectively analyzed the data from 862 EEG sessions in the electronic medical records of 523 patients (mean age, 8.9 ± 6.