A new electrochemical sensing platform based on HgS/graphene composite deposited on the glassy carbon electrode for selective and sensitive determination of propranolol.

Fabrication of selective, sensitive and reliable sensing platform for detection of propranolol (PRO) is still a great challenge. In this study, a new sensitive and selective electrochemical sensor was fabricated for the electrochemical determination of PRO using HgS/graphene composite. The incorporation of HgS microstructures on graphene sheets was done via a facile one-step method, where the simultaneous reduction of GO and the in-situ generation of HgS happened.

A biocompatible nanoplatform formed by MgAl-layered double hydroxide modified MnO/N-graphene quantum dot conjugated-polyaniline for pH-triggered release of doxorubicin.

In this work, for the first time, a novel pH-sensitive biocompatible multifunctional nanocarrier was fabricated by the combination of MgAl-layered double hydroxide, MnO nanoparticles, N-graphene quantum dot and polyaniline (PANI/N-GQD/MO/LDH) for doxorubicin (DOX) delivery in breast cancer cells. Electrochemical techniques, including cyclic voltammetry (CV) and differential pulse voltammetry (DPV), were employed for proving the surface modification process. The integration of polyaniline on the surface of the nanocarrier provides ultrahigh DOX encapsulation up to 90% and possesses a slow-release behavior (4% after 72 h) under normal physiological conditions.

A novel selective ternary platform fabricated with MgAl-layered double hydroxide/NiMnO functionalized polyaniline nanocomposite deposited on a glassy carbon electrode for electrochemical sensing of levodopa.

In this study, a novel selective electrochemical sensor was fabricated for determination of levodopa (LD) using a glassy carbon electrode modified with MgAl-layered double hydroxide/NiMnO functionalized polyaniline nanocomposite (LDH/NMO/PANI) and its successful formation was confirmed by various techniques. Owing to the high surface area and outstanding conductivity features provided by the combination of MgAl-LDH, NiMnO and PANI nanoparticles, this ternary nanocomposite exhibited excellent electrochemical activity towards the detection of LD compared with the electrode modified by the pristine MgAl-LDH and MgAl-LDH/NiMnO binary nanocomposite. In addition, enormous quantities of amine and imine functional groups on the surface of PANI lead to a strong affinity for attachment to organic molecules such as LD.