Publications by authors named "MinSoung Kang"
Article Synopsis
- - ADNP syndrome is linked to developmental delays, intellectual disabilities, and autism spectrum disorders due to issues with the ADNP transcription factor in mice, particularly the Adnp-haploinsufficient (Adnp-HT) type.
- - Adnp-HT mice exhibit cognitive inflexibility and synaptic plasticity deficits, indicated by hyperactivity of the protein CaMKIIα, affecting their learning and memory capabilities and causing social deficits.
- - In adult Adnp-HT mice, the hippocampus shows elevated levels of phosphorylated CaMKIIα and prolonged long-term potentiation (LTP), which could be countered by inhibiting CaMKIIα, suggesting a link between ADNP deficiency and cognitive issues. *
BZ Junctions and Its Application as Probe (2AP) to Detect Z-DNA Formation and Its Effector.
Methods Mol Biol
March 2023
Article Synopsis
- The study focuses on the junction where left-handed Z-DNA meets right-handed B-DNA, highlighting the formation of this junction over time in the genome.
- The BZ junction has a unique base extrusion structure that could assist in identifying Z-DNA formation within DNA strands.
- Researchers explain how to detect this BZ junction structure using a fluorescent probe called 2-aminopurine (2AP), which allows measurement in solution.
Crystallization of Z-DNA in Complex with Chemical and Z-DNA Binding Z-Alpha Protein.
Methods Mol Biol
March 2023
Article Synopsis
- The molecular recognition and stabilization of Z-DNA is primarily understood through X-ray crystallography, which helps visualize its structure.
- Z-DNA forms when sequences alternate between purine and pyrimidine, but creating this structure requires energy, necessitating the use of small stabilizers or specific binding proteins.
- The text details the methods used for preparing DNA and the Z-alpha protein, along with the process for crystallizing Z-DNA.
In the present study, we showed that hydrophilic graphene can serve as an ideal imaging plate for biological specimens. Graphene being a single-atom-thick semi-metal with low secondary electron emission, array tomography analysis of serial sections of biological specimens on a graphene substrate showed excellent image quality with improved-axis resolution, without including any conductive surface coatings. However, the hydrophobic nature of graphene makes the placement of biological specimens difficult; graphene functionalized with polydimethylsiloxane oligomer was fabricated using a simple soft lithography technique and then processed with oxygen plasma to provide hydrophilic graphene with minimal damage to graphene.
View Article and Find Full Text PDFIn the present study, we used the electrochemical transparency of graphene to show that the direct intercalation of alkali-metal cations is not a prerequisite for the redox reaction of Prussian blue (PB). PB thin films passivated with monolayer graphene still underwent electrochemical redox reactions in the presence of alkali-metal ions (K or Na) despite the inability of the cations to penetrate the graphene and be incorporated into the PB. Graphene passivation not only preserved the electrochemical activity of the PB but also substantially enhanced the stability of the PB.
View Article and Find Full Text PDFVisual arrestin (Arr1) terminates rhodopsin signaling by blocking its interaction with transducin. To do this, Arr1 translocates from the inner to the outer segment of photoreceptors upon light stimulation. Mounting evidence indicates that inositol phosphates (InsPs) affect Arr1 activity, but the Arr1-InsP molecular interaction remains poorly defined.
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