Publications by authors named "MinChao Feng"
Article Synopsis
- Safer and more effective treatments for acute pancreatitis (AP) are needed, and Qingjie Huagong decoction (QJHGD) has shown promising clinical effects but its mechanisms were unclear.
- The study aimed to explore how QJHGD influences AP both in cell cultures and in mouse models, using various biochemical and molecular techniques to analyze its effects.
- Results indicated that QJHGD enhances cell viability and reduces pancreatic injury by regulating a specific pathway involving circHipk3, miR-193a-5p, and NLRP3, which highlights a new mechanism for its therapeutic action against AP.
Drug Des Devel Ther
October 2023
Article Synopsis
- YiShen HuoXue decoction (YSHXD) is a traditional formulation used for treating renal fibrosis (RF), and this study investigates its therapeutic effects and underlying mechanisms.
- The research employed network pharmacology and machine-learning to identify key components and targets, followed by experimental validation using HK-2 cells and a rat model induced by unilateral ureteral ligation (UUO).
- Key active compounds like quercetin and kaempferol were found to act on target proteins such as IL-6 and TNF, with YSHXD showing anti-inflammatory effects by inhibiting specific pathways involved in cell death related to RF.
Chin J Integr Med
May 2024
Article Synopsis
- The study aimed to identify the key targets and mechanisms of Dahuang-Danshen (DH-DS) in treating acute pancreatitis (AP) using network pharmacology and animal experiments.
- Sixty-seven common targets were found, with MAPK3, JAK2, STAT3, and FOS highlighted as core targets, while gene ontology and pathway analyses identified cellular response and Th17 cell differentiation as main mechanisms.
- Animal tests confirmed that DH-DS effectively reduced inflammation and protected pancreatic tissue by inhibiting specific inflammatory markers and regulating Th17 cell differentiation.
