Publications by authors named "Min-ho Lee"
Colloidal quantum dots (CQDs) are promising for infrared photodetectors with high detectivity and low-cost production. Although CQDs enable photoinduced charge multiplication, thermal noise in low-bandgap materials limits their performance in IR detectors. Here we present a pioneering architecture of a CQD-based infrared photodetector that uses kinetically pumped avalanche multiplication.
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- - Silver bismuth disulfide (AgBiS) colloidal nanocrystals (CNCs) are eco-friendly materials with great photoconductivity, and when used in solar cells, they meet RoHS guidelines for hazardous substances.
- - To enhance their performance, a new diketopyrrolopyrrole (DPP)-based polymer called BD2FCT is introduced as a hole transport layer, optimizing charge transfer and reducing recombination at the interfaces of the CNCs.
- - The collaboration of BD2FCT with a low-bandgap acceptor, IEICO-4F, leads to more efficient hole transfer and improved overall solar cell performance, achieving a 10.1% power conversion efficiency.
Objective: Despite its potential advantages, robotic surgery has yet to be applied to skull base procedures. Complex anatomy and restricted access have limited the development of robotic skull base surgery. The authors' aim was to conduct a feasibility study of robotic surgery for posterior fossa skull base lesions.
View Article and Find Full Text PDFObjective: The inferior hypophyseal arteries (IHAs) are intimately related to pituitary and cavernous sinus (CS) lesions. There is still no anatomical study specifically analyzing the IHAs. The aim of this study was to investigate the surgical anatomy and variations of the IHA, and to translate this knowledge into surgical practice.
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- - Cervical cancer is strongly associated with Human Papillomavirus (HPV) infection, making its detection crucial for women’s health, but traditional methods like RT-PCR can be expensive and slow.
- - This study presents a new electrochemical biosensor that uses CRISPR technology to detect HPV 16 and 18 genes without the need for nucleic acid amplification, enhancing both efficiency and cost-effectiveness.
- - The biosensor is highly sensitive, able to detect L1 genes at extremely low concentrations, and shows results comparable to conventional methods, indicating its potential for use in clinical diagnostics and point-of-care testing.
Article Synopsis
- A new viscoelastic flow focusing device is designed to effectively concentrate submicron-sized particles, including bacteria, in the center of a microchannel without external forces by adjusting factors like channel length and fluid composition.
- The device uses a long polydimethylsiloxane (PDMS) channel, allowing for high flow rates and successful focusing of particles as small as 100 nm with impressive efficiency.
- Demonstrations with polystyrene beads and E. coli bacteria show the device’s potential for biological and clinical applications, such as pathogen detection and antibiotic response evaluations in single tests.
Elucidating Clinical Queries for Tailored Therapy in Patients with Prolactinoma.
Endocrinol Metab (Seoul)
December 2024
Article Synopsis
- * While medication effectively reduces tumor size and hormone levels, issues such as treatment duration and side effects can impact patient adherence.
- * Recent advancements in surgical techniques and precision medicine offer opportunities for personalized treatment plans, focusing on factors like DA sensitivity, surgical suitability, and patient safety, especially during pregnancy and breastfeeding.
Article Synopsis
- This study explored the optical properties of two types of implant-supported crowns made from CAD/CAM ceramics: multi-colored lithium disilicate (AMD) and multi-layered zirconia (OM), focusing on how liner treatments affect their translucency and fracture strength.
- Results showed that untreated AMD had the highest translucency, while liner treatments reduced translucency but the addition of color increased it again.
- Fracture strength was strongest in Ti abutment-OM crowns (548.03 N) and weakest in Zr abutment-AMD crowns (283.58 N), indicating that titanium supports are better for these types of crowns, which can also be adjusted for aesthetics using color liners.
Article Synopsis
- The study aimed to identify and analyze spliceosome components that are expressed differently in growth hormone-secreting pituitary tumors compared to normal tissues.
- Researchers conducted a transcriptome analysis on tumor samples and normal pituitary tissues, revealing that higher expression levels of the TCERG1 gene were linked to poorer surgical outcomes in patients with acromegaly.
- Findings suggest that TCERG1 promotes tumor cell growth and invasion, indicating its potential as a biomarker for the aggressiveness of GH-secreting pituitary tumors.
Article Synopsis
- Hybrid perovskite/organic solar cells (HSCs) are gaining attention due to their easy manufacturing, wide photon absorption, and low voltage losses.
- A significant challenge in improving their efficiency is the energy mismatch at the interface, causing charge buildup.
- This study shows that adding a sub-nanometer dipole layer helps minimize this mismatch, leading to improved voltage and carrier movement, ultimately boosting the efficiency of HSCs to a record 24.0%.
Article Synopsis
- - The study focused on creating core-shell hydrogel beads to control the release of vitamin B12, using gellan gum to make vitamin B12-loaded microgels (MG).
- - These core-shell beads were developed by adding the microgels into a matrix of pea protein isolate and sodium alginate, with varying amounts of inulin to enhance the structure and encapsulation efficiency.
- - Results showed that as the inulin concentration increased, the beads had a smoother surface, improved encapsulation efficiency, and exhibited a slower, more sustained release of vitamin B12 under simulated digestive conditions compared to the microgels alone.
Article Synopsis
- Understanding emotional states is key for improving human-machine interfaces, as human behaviors in social settings influence psychological and physiological responses.* -
- The study presents a unique multimodal emotion dataset from 42 participants, featuring data from EEG, audio, and video recordings that capture five distinct emotions during conversational interactions.* -
- This Emotion in EEG-Audio-Visual (EAV) dataset is the first of its kind for emotion recognition and aims to enhance research in both neuroscience and machine learning, providing insights into human emotions.*
Article Synopsis
- * Originally thought to mainly function as a hormone in the periphery, new findings have required improved detection methods, prompting the use of advanced biosensors for quick and efficient analysis.
- * This review discusses recent advancements in optical and electrochemical biosensors for serotonin, examining strategies that enhance performance, and highlights innovative applications utilizing nanomaterials in various biomedical fields.
Background And Objectives: The transorbital approach (TOA) facilitates access to pathologies lateral to the optic nerve, a region that is difficult to access with an endonasal approach. In this study, we sought to investigate the feasibility of robotic-assisted surgery in lateral TOA.
Methods: Six colored-silicon-injected human postmortem heads were prepared for dissection.
Importance of Preoperative Pupillary Reflex in Traumatic Optic Neuropathy.
J Korean Neurosurg Soc
August 2024
Objective: Traumatic optic neuropathy (TON) refers to a pathological condition caused by direct or indirect injury to the optic nerves. In the case of patients with traumatic brain injury, adequate vision evaluation is difficult in many cases due to altered mentality. In order to address this problem, we investigated preoperative pupillary light reflex in TON patients as a predictive factor of surgical outcomes after optic nerve decompression.
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- Excess growth hormone (GH) from pituitary adenomas can promote the development and spread of triple-negative breast cancer (TNBC).
- In an acromegaly mouse model, researchers found that elevated GH activated TCF20, leading to the activation of NRF2-target genes that enhance TNBC metastasis.
- Blocking GH receptors or TCF20 activity reduced tumor size and spread, indicating that targeting this signaling pathway could be a promising treatment for TNBC.
Article Synopsis
- - Magnesium implants often lose strength quickly after being implanted due to bioabsorption, increasing the risk of rupture, but a new polymer coating can help manage this issue.
- - The biosafe coating combines polycaprolactone (PCL) and MXenes, which protects the implants for up to 28 days and promotes cell growth without being toxic.
- - When exposed to near-infrared light for just 20 minutes, the coating degrades effectively, allowing for controlled bioabsorption and revealing the magnesium substrate, even in liquid environments.
Article Synopsis
- - The study aimed to explore the relationship between serum hemoglobin (Hb) levels and the risk of carotid plaque, which is a sign of subclinical atherosclerosis, in individuals without a history of cardiovascular disease (CVD).
- - Researchers analyzed data from 3,805 participants who underwent carotid ultrasonography, dividing them into groups based on their Hb levels, and found that higher Hb levels were linked to a greater presence of significant carotid plaques in both males and females.
- - The findings suggest that elevated Hb levels can increase the risk of carotid plaques, indicating a potential need for early cardiovascular disease screening in individuals with high Hb levels.
Objective: The internet, particularly social media, has become a popular resource for learning about health and investigating one's own health conditions. The development of artificial intelligence (AI) chatbots has been fueled by the increasing availability of digital health data and advances in natural language processing techniques. While these chatbots are more accessible than before, they sometimes fail to provide accurate information.
View Article and Find Full Text PDFObjective: Tumors located in the retrochiasmatic region with extension to the third ventricle might be difficult to access when the pituitary-chiasmatic corridor is narrow. Similarly, tumor extension into the interpeduncular and retrosellar space poses a major surgical challenge. Pituitary transposition techniques have been developed to gain additional access.
View Article and Find Full Text PDFBackground: The development of artificial intelligence (AI) raises ethical concerns about its side effects on the attitudes and behaviors of clinicians and medical practitioners. The authors aim to understand the medical ethics of AI-based chatbots and to suggest coping strategies for an emerging landscape of increased access and potential ambiguity using AI.
Methods: This study examines the medical ethics of AI-based chatbots (Chat generative pretrained transformer [GPT], Bing Chat, and Google's Bard) using multiple-choice questions.
Lateral flow assays have been widely used for detecting coronavirus disease 2019 (COVID-19). A lateral flow assay consists of a Nitrocellulose (NC) membrane, which must have a specific lateral flow rate for the proteins to react. The wicking rate is conventionally used as a method to assess the lateral flow in membranes.
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