Publications by authors named "Min-Zhi He"
Hypoxic-ischemic encephalopathy (HIE) is recognized as the main cause of neonatal death, and efficient treatment strategies remain limited. Given the prevalence of HIE and the associated fatality, further studies on its pathogenesis are warranted. Oxidative stress and neuroinflammatory injury are two important factors leading to brain tissue injury and nerve cell loss in HIE.
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- Hypoxia can cause serious brain damage in newborns, leading to disabilities or death, and existing treatments aren't very effective.
- Lipoxin A4 (LXA4) could help reduce inflammation and protect brain cells after injury, but not much research has been done on it in the brain.
- In tests with baby rats, LXA4 showed it can help their brains heal after injury by reducing swelling and inflammation and keeping the brain safe from damage.
Neonatal hypoxic-ischemic (HI) brain injury is a detrimental disease, which results in high mortality and long-term neurological deficits. Nevertheless, the treatment options for this disease are limited. Thus, the aim of the present study was to assess the role of liraglutide in neonatal HI brain injury in rats and investigate the associated mechanisms.
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