Publications by authors named "Min-You Wu"
Article Synopsis
- Exercise is beneficial for cancer patients, especially in post-surgery rehabilitation, but there hasn’t been much research specifically on its effects after nephrectomy surgery.
- An animal model was created to simulate nephrectomy patients with and without exercise, and bioinformatics analysis was performed on lung tissue samples using RNA sequencing data.
- The analysis revealed that exercise improves immune-related gene expression pathways in nephrectomy models, indicating potential genetic mechanisms behind the positive effects of exercise after surgery.
Background/aim: Radiation dermatitis is a common complication of radiation therapy in breast cancer patients. Severe dermatitis may alter treatment schedules and clinical outcomes. The topical prevention strategy is the widely used option to prevent radiation dermatitis.
View Article and Find Full Text PDFObjective: Obstructive sleep apnea (OSA) results from upper airway remodeling, which has been suggested to alter sensory and motor neuron function due to hypoxia or snore vibration. This study investigated whether OSA was associated with the risk of flavor disorder (FD).
Materials And Methods: Seven thousand and eight hundred sixty-five patients with OSA and 7865 propensity score-matched controls without OSA were enrolled between 1999 and 2013 through a nationwide cohort study.
: PNU-74654, a Wnt/β-catenin inhibitor, has reported antitumor activities; however, the therapeutic potential of PNU-74654 in hepatocellular carcinoma (HCC) has not been investigated in detail. The aim of this study was to clarify the cytotoxic effects of PNU-74654 against HCC and to uncover its molecular mechanism. : HepG2 and Huh7 liver cancer cell lines were selected to determine the antitumor properties of PNU-74654.
View Article and Find Full Text PDFBackground/aim: Head and neck cancer is a major malignancy worldwide. The treatment strategy for head and neck cancer usually involves radiotherapy. The main side effect of radiotherapy is radiation dermatitis.
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- Azacitidine inhibits DNA methylation, showing promise as a treatment for various cancers, including urinary bladder urothelial carcinoma (UBUC), but its effectiveness through intravesical instillation (IVI) was previously unclear.
- In studies, azacitidine significantly reduced cell viability and proliferation in UBUC cell lines, alongside inducing apoptosis by affecting specific signaling pathways related to tumor necrosis factor (TNF) and TRAIL (TNF-related apoptosis-inducing ligand).
- In a rat model of BBN-induced bladder cancer, IVI of azacitidine decreased tumor burden and cell proliferation markers, suggesting its potential for therapeutic use and warranting further clinical research.
Lung cancer is one of the leading causes of death in both the USA and Taiwan, and it is thought that the cause of cancer could be because of the gain of function of an oncoprotein or the loss of function of a tumour suppressor protein. Consequently, these proteins are potential targets for drugs. In this study, differentially expressed genes are identified, via an expression dataset generated from lung adenocarcinoma tumour and adjacent non-tumour tissues.
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