Publications by authors named "Min-Wen Zheng"

The traditional approach of using PowerPoint (PPT) presentations in medical imaging theory classes hinders the spatial thinking ability of most students. Consequently, the learning outcomes are often unsatisfactory. This article proposes a naked eye three-dimensional (3D) medical imaging teaching assistant app based on augmented reality (AR) technology to enhance learning interest, teaching interaction, and effectiveness.

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Objectives: To evaluate the performance of coronary computed tomography angiography (CCTA) derived characteristics including CT derived fractional flow reserve (CT-FFR) with FFR as a reference standard in identifying the lesion-specific ischemia by machine learning (ML) algorithms.

Methods: The retrospective analysis enrolled 596 vessels in 462 patients (mean age, 61 years ± 11 [SD]; 71.4 % men) with suspected coronary artery disease who underwent CCTA and invasive FFR.

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Objectives: To investigate the optimal measurement site of coronary-computed tomography angiography-derived fractional flow reserve (FFR CT ) for the assessment of coronary artery disease (CAD) in the whole clinical routine practice.

Materials And Methods: This retrospective multicenter study included 396 CAD patients who underwent coronary-computed tomography angiography, FFR CT , and invasive FFR. FFR CT was measured at 1 cm (FFR CT -1 cm), 2 cm (FFR CT -2 cm), 3 cm (FFR CT -3 cm), and 4 cm (FFR CT -4 cm) distal to coronary stenosis, respectively.

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Objectives: To propose a novel functional Coronary Artery Disease-Reporting and Data System (CAD-RADS) category system integrated with coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) and to validate its effect on therapeutic decision and prognosis in patients with coronary artery disease (CAD).

Methods: Firstly, we proposed a novel functional CAD-RADS and evaluated the performance of functional CAD-RADS for guiding treatment strategies with actual clinical treatment as a reference standard in a retrospective multicenter cohort with CCTA and invasive FFR performed in all patients (n = 466). Net reclassification improvement (NRI) of functional CAD-RADS over anatomical CAD-RADS was calculated.

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Article Synopsis
  • The study focuses on developing a radiomic signature from MRI scans to predict disease-free survival (DFS) in patients with locally advanced cervical cancer who received chemoradiotherapy.
  • It involved analyzing MRI data from 263 patients and used statistical methods like LASSO and Cox regression to create a signature highlighting four key features associated with poorer DFS.
  • Results showed that this radiomic signature performed better in predicting DFS compared to traditional clinical models, suggesting its potential as a valuable non-invasive prognostic tool for high-risk patients.
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  • - The study analyzed the effectiveness of machine learning-based fractional flow reserve (FFR) derived from coronary CT angiography (CCTA) in diagnosing coronary artery disease in diabetes mellitus (DM) patients by comparing it with non-DM patients across 484 individuals from various medical centers in China.
  • - The results indicated that FFR exhibited high sensitivity and specificity in both DM (79% sensitivity, 96% specificity) and non-DM (82% sensitivity, 93% specificity) groups, showing no significant differences between them.
  • - The findings conclude that diabetes did not adversely affect the accuracy of FFR, emphasizing its superiority over CCTA alone for detecting ischemia and noting that coronary calcification did not impact FFR's diagnostic
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  • The study aimed to assess the effectiveness of contrast-enhanced ultrasonography (CEUS) in selecting uterine fibroids for MR-guided focused ultrasound (MRgFUS) ablation and evaluating the treatment's outcomes compared to traditional MR imaging.
  • Involving 44 fibroids from 38 patients, the research analyzed pre-ablation characteristics using multivariable linear regression to determine their association with non-perfusion volume (NPV) after treatment.
  • Results showed CEUS's performance (AUC 0.95) in predicting NPV was superior to MR imaging (AUC 0.86), indicating that CEUS can be a viable alternative for patient assessment and outcome evaluation in fibroid ablation procedures.
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Purpose: To evaluate the predictive value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in treatment response to concurrent chemoradiotherapy (CCRT) for locally advanced cervical squamous cell carcinoma (LACSC).

Methods And Materials: LACSC patients underwent CCRT had DCE-MRI before (e0) and after 3 days of treatment (e3). Extended Tofts Linear model with a user arterial input function was adopted to generate quantitative measurements.

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Objective: To investigate the effect of coronary calcification morphology and severity on the diagnostic performance of machine learning (ML)-based coronary CT angiography (CCTA)-derived fractional flow reserve (CT-FFR) with FFR as a reference standard.

Methods: A total of 442 patients (61.2 ± 9.

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Objective: To investigate the effect of image quality of coronary CT angiography (CCTA) on the diagnostic performance of a machine learning-based CT-derived fractional flow reserve (FFR).

Methods: This nationwide retrospective study enrolled participants from 10 individual centers across China. FFR analysis was performed in 570 vessels in 437 patients.

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Article Synopsis
  • A study examined the ability of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) to detect ischemia in patients with myocardial bridging (MB), involving 104 participants with varying degrees and types of MB.
  • The results indicated that CT-FFR had a high sensitivity (96%) and good accuracy (89%) in identifying functional ischemia compared to the invasive fractional flow reserve (FFR) method, with no significant differences based on the type or length of MB.
  • Despite promising findings, the authors emphasize the need for further research to confirm the clinical applicability of CT-FFR for patients with MB and related coronary artery disease.
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Objectives: The aim of this study was to validate the feasibility of a novel structural and computational fluid dynamics-based fractional flow reserve (FFR) algorithm for coronary computed tomography angiography (CTA), using alternative boundary conditions to detect lesion-specific ischemia.

Background: A new model of computed tomographic (CT) FFR relying on boundary conditions derived from structural deformation of the coronary lumen and aorta with transluminal attenuation gradient and assumptions regarding microvascular resistance has been developed, but its accuracy has not yet been validated.

Methods: A total of 338 consecutive patients with 422 vessels from 9 Chinese medical centers undergoing CTA and invasive FFR were retrospectively analyzed.

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Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28-year-old Chinese male admitted to our hospital with the symptoms of chest tightness and shortness of breath due to a recurrent fibrolipoma in the mediastinum.

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Background: Both low tube voltage and sinogram-affirmed iterative reconstruction (IR) techniques hold promise to decrease radiation dose at coronary CT angiography (CCTA). The increased iodine contrast at low tube voltage allows for minimizing iodine load.

Objective: To assess the effect of reduced x-ray tube voltage, low iodine concentration contrast medium and IR on image quality and radiation dose at CCTA.

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Endothelial progenitor cells (EPCs) have an essential role in counteracting risk factor‑induced endothelial injury and protecting against the development of vascular injury, such as myocardial infarction. Magnetic resonance imaging (MRI) was reported to be effective in tracking transplanted stem cells following cell‑labeling with superparamagnetic iron oxide (SPIO) nanoparticles. SPIO has previously been used to label and track EPCs; however, the safest concentration of SPIO for labeling EPCs on a cellular level has remained to be elucidated.

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Gorham-Stout syndrome (GSS), also known as Gorham-Stout disease, massive osteolysis, disappearing bone disease or phantom bone, is a rare disorder of the musculo-skeletal system. It most commonly involves the skull, shoulder and pelvic girdle. Histological examination reveals a progressive osteolysis always associated with an angiomatosis of blood vessels and sometimes of lymphatics, which seemingly is responsible for the destruction of the bone.

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Aim: To construct a dual promoter lentivira vector containing TFR and VEGF gene, and detect the expression of TFR and VEGF genes in MSCs of Chinese mini-swine.

Methods: The TFR and VEGF gene were amplified by polymerase chain reaction and cloned into pLenti-GFP-Neo after the CMV and SV40 promoter respectively, to generate the lentivira vector pLenti-TG-VEGF. The four-plasmids lentiviral vector system(pRsv-REV, pMDlg-pRRE, pMD2G and pLenti-TG-VEGF)were cotransfected into human embryonic kidney 293 T cells with Lipofectin 2000 reagent.

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Objective: To analyze the imaging characteristics of coronary arteries with total occlusion (TO) lesions shown by dual-source computed tomography CT (DSCT) coronary angiography.

Method: The clinical data of patients who were diagnosed as coronary heart disease together with total occlusion lesions between March 2008 and March 2010 were retrospectively analyzed.

Results: In a cohort of 140 patients with 152 TO lesions, TO vessels in right coronary artery, left anterior descending artery, left circumflex coronary artery, or left main coronary artery were 68, 48, 20, and 1, respectively.

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We report a case of primary gastrointestinal stromal tumor (GIST) of the liver. A 17-year-old man with a solid mass in the anterior segment of the right liver was asymptomatic with negative laboratory examinations with the exception of positive HBV. Contrast-enhanced ultrasound (CEUS) revealed a hypervascular lesion in the arterial phase and hypoechoic features during the portal and late phases.

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Objective: To study the effects of 16-multi-detector row CT (MDCT) aortography with lower tube current in diagnosis of aortic diseases.

Methods: The study was conducted in 2 steps. In the first step, 58 patients with suspicious aortic disease or after operation on the aorta underwent 16-MDCT aortography for 70 times.

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Objective: To assess the value of electron beam CT (EBCT) in the diagnosis of aortic intramural hematoma (AIH).

Methods: Twenty-five patients who complained of acute chest and back pain were scanned with an EBCT scanner (Imatron C-150) using contrast-enhanced continuous volume scanning (CVS) for establish the diagnosis of AIH.

Results: Seven patients were diagnosed as having Stanford type A, and the others as type B AIH.

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