Publications by authors named "Min-Seok Woo"

Fermented and aged mountain-cultivated ginseng sprouts (FAMCGS) exhibit superior antioxidant and anti-inflammatory properties compared to mountain-cultivated ginseng sprouts (MCGS). However, the mechanisms behind these properties of FAMCGSE remain unclear. This study explores the anti-inflammatory effects of FAMCGS extract (FAMCGSE) on LPS-stimulated RAW 264.

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Growth arrest and DNA damage-inducible beta (GADD45b) plays a critical role in intracellular events such as cell growth and apoptosis. Although the functional study of GADD45b has been conducted, the mechanism for the transcriptional regulation of GADD45b is largely unknown. Due to the drastic induction of hepatic GADD45b mRNA by peroxisome proliferator-activated receptor alpha activation in wild-type mice, we investigated a key factor that affects the upregulation of GADD45b mRNA.

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Article Synopsis
  • - Ovarian cysts may be linked to hormone imbalances and gene expression changes, with a focus on the role of TASK ion channels, particularly TASK-3, in their formation.
  • - The study found that large ovarian follicles (LFs) had significantly lower potassium (K) concentrations and around 50% reduced TASK-3 expression compared to smaller follicles (SFs), suggesting a relationship between TASK-3 levels and follicle size.
  • - Reduced TASK-3 expression in granulosa cells from LFs led to inhibited growth and cell senescence, indicating that lower levels of TASK-3 might contribute to ovarian cyst development.
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L., a member of the Anacardiaceae family, is widely cultivated across the globe. The leaves of are renowned for their medicinal properties, attributed to the abundance of bioactive compounds.

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Object: We retrospectively analyzed clinical data to evaluate the safety and efficacy of single antiplatelet therapy (SAPT) after stent-assisted coil embolization (SAC) for ruptured cerebral aneurysms.

Methods: In total, 176 stent-assisted coil embolization procedures were investigated. Among them, 77 ruptured and 99 unruptured aneurysms were grouped and compared respectively.

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Article Synopsis
  • - The study compares the effectiveness of two techniques for treating unruptured vertebral artery dissecting aneurysms (VADAs): a single flow diverter (FD) and multiple telescopic stenting (TS).
  • - Researchers analyzed data from 39 patients, finding that both methods successfully achieved flow diversion, but the FD technique had a shorter procedure duration.
  • - While both techniques showed good results, the single FD method was preferable due to its quicker procedure time and efficiency in achieving complete flow diversion.
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The association between asthma and oxidative stress remains controversial. Oxidative stress-induced ferroptosis has not been extensively studied in asthma models. This study was performed to investigate the anti-asthmatic and anti-ferroptotic effects of fermented and aged ginseng sprouts (FAGS) with enhanced antioxidant activity and its main component, compound K (CK), in a mouse model of ovalbumin (OVA)-induced allergic asthma.

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Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters () with economic value. OBC is a by-product of boiling oysters at 95°C for 3 min.

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Garlic, a once-a-year crop, is mass-produced in a single event. Most of the garlic harvested during the year, unless consumed or processed immediately, should be stored. Stored raw garlic (SRG) can be used to make black garlic (BG) via aging, and storage may affect the properties and quality of the BG compared with the use of raw garlic that has not been stored.

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Models created by the intraperitoneal injection of lipopolysaccharide (LPS) and D-galactosamine (D-GalN) have been widely used to study the pathogenesis of human acute liver failure (ALF) and drug development. Our previous study reported that oyster (Crassostrea gigas) hydrolysate (OH) had a hepatoprotective effect in LPS/D-GalN-injected mice. This study was performed to identify the hepatoprotective effect of the tyrosine-alanine (YA) peptide, the main component of OH, in a LPS/D-GalN-injected ALF mice model.

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Background: Prolotherapy is a proliferation therapy as an alternative medicine. A combination of dextrose solution and lidocaine is usually used in prolotherapy. The concentrations of dextrose and lidocaine used in the clinical field are very high (dextrose 10%-25%, lidocaine 0.

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TWIK (tandem-pore domain weak inward rectifying K)-related spinal cord K channel (TRESK), a member of the two-pore domain K channel family, is abundantly expressed in dorsal root ganglion (DRG) neurons. It is well documented that TRESK expression is changed in several models of peripheral nerve injury, resulting in a shift in sensory neuron excitability. However, the role of TRESK in the model of spinal cord injury (SCI) has not been fully understood.

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Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (), which can be easily eaten in meals.

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Persistent organic pollutants (POPs) such as organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have become wide-spread environmental contaminants as a consequence of their extensive use, long-range transport, and persistence. Because POPs are highly resistant to metabolic degradation, humans bioaccumulate these lipophilic and hydrophobic pollutants in fatty tissues for many years. Previous studies have demonstrated that POPs including PCBs are involved in the development of diabetes mellitus (DM) type 2 and insulin resistance.

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Article Synopsis
  • Epidemiological studies indicate a link between polychlorinated biphenyls (PCBs) and obesity, yet the underlying molecular mechanisms are not fully understood.
  • This study focused on how PCB-138 causes lipid droplet (LD) enlargement in adipocytes, potentially helping these fat cells resist cell death and contributing to obesity.
  • Key findings revealed that PCB-138 protects adipocytes from TNF-α-induced cell death by enhancing the expression of anti-apoptotic proteins like survivin, along with proteins Fsp27 and perilipin that help maintain enlarged LDs.
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Although heat-shock transcription factors are well characterized in the heat stress-related pathway, they are poorly understood in other stress responses. Here, we functionally characterized AtHsfA6a in the presence of exogenous abscisic acid (ABA) and under high salinity and dehydration conditions. AtHsfA6a expression under normal conditions is very low, but was highly induced by exogenous ABA, NaCl and drought.

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