Publications by authors named "Min-Qing Wu"
Article Synopsis
- The study focuses on hereditary diffuse gastric cancer (HDGC) and the role of specific genes, particularly CDH1, which accounts for a portion of hereditary cases, while still leaving 50% to 75% of cases unexplained.
- Researchers conducted a cohort study analyzing genetic samples from 284 HDGC patients in China to assess CDH1 gene alterations and identify potential new susceptibility genes.
- Results showed a low incidence of CDH1 germline alterations (2.8%) but identified several other genes with higher rates of private germline alterations, suggesting a complex genetic landscape and environmental factors in HDGC.
The number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs.
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- The study investigates the effectiveness of 75 genetic variants linked to colorectal cancer (CRC) in a Chinese population, focusing on the development of a predictive model.
- A risk prediction model that incorporates 19 variants showed some clinical benefits, achieving a moderate accuracy with AUC values between 0.59 and 0.61 during validation.
- Individuals in the highest risk quartile had more than double the likelihood of developing CRC compared to those in the lowest risk quartile, suggesting that this genetic model could help tailor CRC prevention strategies for individuals in China.
The number of axillary lymph nodes involved and retrieved are important prognostic factors in breast cancer. The purpose of our study was to investigate whether the lymph node ratio (LNR) is a better prognostic factor in predicting disease-free survival (DFS) for breast cancer patients as compared with pN staging. The analysis was based on 804 breast cancer patients who had underwent axillary lymph node dissection between 1999 and 2008 in Sun Yat-Sen University Cancer Center.
View Article and Find Full Text PDFBackground: Low tyrosine-protein phosphatase nonreceptor type 12 (PTPN12) expression may be associated with breast cancer growth, proliferation, and metastasis. However, the prognostic value of PTPN12 in breast cancer has not been clearly identified.
Patients And Methods: 51 triple-negative breast cancer (TNBC) patients and 83 non-TNBC patients with a histopathology diagnosis from October 2001 to September 2006 were included in this study.