Publications by authors named "Min-Min Liu"

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  • * Grazing has been found to increase dominance in typical and desert grasslands while decreasing it in meadow grasslands, with varying effects on biomass and carbon stocks.
  • * Research suggests that geographic, climatic, and soil factors significantly influence biomass and carbon stocks across different grassland types, highlighting the need for better management practices.
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  • - SHP1 is a key player in cancer-related signaling pathways, making it a promising target for new cancer drugs.
  • - Researchers created imidazo[1,2,4] triazole derivatives for SHP1 inhibition, focusing on their fluorescence properties and biological activity.
  • - The compound 5p showed strong fluorescence and a significant inhibitory rate against SHP1, along with good selectivity and biocompatibility, indicating its potential for biological imaging applications.
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  • Fluorescence imaging serves as a crucial link between molecular biology and clinical medicine, offering rapid and non-invasive methods for disease research, early diagnosis, and treatment evaluation.
  • Researchers designed and synthesized various fluorescent molecules based on thiadiazole, thiazole, and benzothiazole cores to enhance bio-imaging capabilities.
  • Among the tested compounds, benzothiazole derivative 14 B stood out for its exceptional fluorescence qualities and low cytotoxicity, making it a promising candidate for confocal cell imaging.
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Current therapy for acute myeloid leukemia (AML) is largely hindered by the development of drug resistance of commonly used chemotherapy drugs, including cytarabine, daunorubicin, and idarubicin. In this study, we investigated the molecular mechanisms underlying the chemotherapy drug resistance and potential strategy to improve the efficacy of these drugs against AML. By analyzing data from ex vivo drug-response and multi-omics profiling public data for AML, we identified autophagy activation as a potential target in chemotherapy-resistant patients.

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Combination treatments are commonly prescribed for enhancing drug efficacy, as well as for preventing the evolution of resistance. The interaction between drugs is typically evaluated near the MIC, using growth rate as a measure of treatment efficacy. However, for infections in which the killing activity of the treatment is important, measurements far above the MIC are needed.

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  • * Researchers identified 45 active components in SQW and 72 potential COVID-19-related targets, highlighting key proteins such as ACE2 and IL-6, and found significant enrichment in 1715 gene ontology (GO) projects and 136 KEGG pathways related to inflammation and cellular response.
  • * Molecular docking studies indicated strong binding capabilities of several active compounds like kaempferol and quercetin with important COVID-19 targets, suggesting SQW could be effective in managing the disease.
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  • This study explores how the combination of Platycodonis Radix and Lilii Bulbus might help treat pneumonia using network pharmacology and lab experiments.
  • Researchers identified 12 active components from the two plants that target pneumonia-related pathways, focusing on inflammation and cell growth.
  • The findings suggest these components effectively bind to key targets, and lab tests confirm they can reduce the expression of important inflammatory markers like MMP9 and TNF-α.
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Polygonati Rhizoma(PR), listed as a top-grade medicine, was recorded first in the Mingyi Bielu written by TAO Hongjing. It is a good medicine through the ages to tonify Qi and nourish Yin, strengthen spleen and kidney. PR has a long history of processing and has a variety of processing methods and technologies.

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Excellent nonlinear optical materials simultaneously meet the requirements of large SHG response, phase-matching capability, wide transparency windows, considerable energy band-gap, good thermal stability and structure stability. Herein, two new promising nonlinear optical (NLO) crystals LiM (IO ) (M =Zn and Cd) are rationally designed by the aliovalent substitution strategy from the commercialized α-LiIO with the perfect parallel alignment of IO groups. Compared with parent α-LiIO and related A M (IO ) , the title compounds exhibit more stable covalent 3D structure, and overcome the racemic twinning problem of A M (IO ) .

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Silver doped TiO (Ag-TiO) materials show high activity and good stability in photocatalysis, but the mechanism could not be illustrated clearly due to their imprecise and inhomogeneous characteristics. Ag-doped titanium-oxo clusters (Ag-TOCs) with an exact crystal structure, which are rarely reported, are beneficial for further understanding structure-property relationships. Herein, six new Ag-TOCs with a butterfly-like TiAg core have been synthesized through facile solvothermal reactions, in which two Ag ions are successfully linked to the surface of the Ti core.

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MicroRNA-30e (miR-30e) is downregulated in various tumor types. However, its mechanism in inhibiting tumor growth of breast cancer remains to be elucidated. In this study, we found that miR-30e was significantly downregulated in tumor tissues of breast cancer (BC) patients and cell lines, and overexpression of miR-30e inhibited cell proliferation, migration and invasion.

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The ground state vibrational energy and spatial features of (4)He-(4)He-Li(+) and its triatomic isotopic complexes are studied using the slow variable discretization (SVD) method in the hyperspherical coordinates for the zero total angular momentum. Our results show that the dominant structure of the system is an isosceles triangle with the shorter side associated with the two Li(+)-He distances using the sum-of-potential approximation. Corrections caused by the induced dipole-induced dipole interactions on the He atoms are also investigated.

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It is currently known that estrogen plays an important role in breast cancer (BC) development, but the underlying molecular mechanism remains to be elucidated. Accumulating evidence has revealed important roles of microRNAs in various kinds of human cancers, including BC. In this study, we found that among the microRNAs regulated by estrogen, miR-124 was the most prominent downregulated miRNA.

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The reversible crystal transformation between the mononuclear complex [Cu(tzbc)2(H2O)4] (1) and the 4-fold interpenetrated diamondoid MOF [Cu(tzbc)2] (2) was chemically implemented and structurally interpreted. Interestingly, despite 4-fold interpenetration, desolvated with 1D channels and rich N-groups shows exclusive CO2 adsorption of up to 12.5 wt% at room temperature and low pressure, indicating potential application in the separation of industrial and automobile exhaust.

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Seven cupric halide coordination polymers, namely [Cu5(OH)3Br3(ina)4] (1), [Cu5(OH)3Cl3(ina)4] (2), [Cu2(OH)Cl(ina)2] (3), [Cu3(OH)2Cl2(ina)2]·2H2O (4), [Cu3(OH)2Br2(ina)2]·2H2O (5), [Cu2Cl2(ina)2(H2O)2] (6), [Cu2Cl(ina)2(gca)(H2O)] (7), cupric complex templated cuprous halide [Cu(II)(Me-ina)2(H2O)][Cu(I)5Br7] (8), and organic templated cuprous halide Me2-ina[Cu2Br3] (9) (Hina = isonicotinic acid), were prepared from the starting materials of cupric halide and Hina via fine-tuning solvothermal reactions. According to valence states of copper, 1-7 are copper(II) complexes, 8 is a mixed-valent Cu(I,II) complex, while 9 is a Cu(I) compound. According to bonding types of halides, nine complexes can be classified as three types: complexes 1-3 include only normal X-Cu bond (X = halide); complexes 4-7 include normal X-Cu bond and X···Cu weak bond; complexes 8 and 9 include normal X-Cu bond and X···H-C halogen hydrogen bonds.

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In the title compound, {(C4H12N)[Mn(HCO2)3]} n , the Mn(II) atom lies on an inversion centre and is coordinated by O-atom donors from the three double-bridging formate ligands, one of which lies across a crystallographic mirror plane, giving a slightly distorted octahedral coordination sphere. A three-dimensional NaCl-type framework is generated in which the tetra-methyl-ammonium cations, which lie across mirror planes and occupy the cavities in the polymer structure, form weak C-H⋯O hydrogen bonds with the formate ligands.

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By using environmentally friendly [Ni(CN)4](2-) as a cyanide source, three new heterometallic cyano-bridged mixed-valence Cu(I)/Cu(II) coordination polymers with three different electronic configurations (d(8)-d(10)), that is, [Cu2Ni(CN)5(H2O)3] (1), [Cu2Ni(CN)5(pn)H2O] (2), and [Cu3Ni(CN)6(pn)2] (3, pn = 1,2-propane diamine) have been synthesized by gradually increasing the amount of pn. Compound 1, which was hydrothermally synthesized in the absence of pn ligand, exhibits the famous 2D Cairo pentagonal tiling, in which the Cu(I), Cu(II), and Ni(II) atoms act as trigonal, T-shaped, and square-planar nodes, respectively. Notably, there are three water molecules located at the meridianal positions of the octahedrally coordinated Cu(II) atom in compound 1.

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Lappaconitine instead of its hydrobromide salts has been encapsulated in poly (lactide-co-glycolide) acid (PLGA) microspheres by the simple o/w emulsion solvent evaporation technique. The effects of several variables including emulsifier (polyvinyl alcohol, PVA) concentration, stirring speed, PLGA concentration and drug/polymer mass ratios on quality of microspheres have been investigated. The particle size and size distribution can be controlled by PVA concentration, stirring speed and PLGA concentration.

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