[Effect of Lipoteichoic Acid Synthesis-Related Gene on Acid Tolerance of Highly Cariogenic Strains of ].

Objective: To study the role and possible mechanism of in the acid tolerance of 593 (593), and to provide a theoretical basis for the ecological prevention and control of dental caries by constructing the gene deletion strain of 593 (593-Δ).

Methods: 1) 593-Δ was constructed by homologous recombination. 2) The growth curve of 593 and 593-Δ under different pH culture conditions was drawn by the automatic growth curve analyzer to compare their acid tolerance.