Bioactive secondary metabolites from tomato-derived bacterium Hnu24.

A series of secondary metabolites have been isolated from the genus of , most of which show antibacterial and insecticidal activities. In order to find more bioactive secondary metabolites from , one new natural component aminoindole dimer baciindole A (), together with seven known compounds () were isolated from the tomato-derived bacterium Hnu24. The structure of compound was elucidated by its HR-ESI-MS spectral data and 1 D/2D NMR spectroscopic analysis.

Talaromarins A-F: Six New Isocoumarins from Mangrove-Derived Fungus TGGP35.

Six new isocoumarin derivative talaromarins A-F (-), along with 17 known analogues (-), were isolated from the mangrove-derived fungus (Eurotiales: Trichocomaceae) TGGP35. Their structures were identified by detailed IR, UV, 1D/2D NMR and HR-ESI-MS spectra. The absolute configurations of new compounds were determined by the modified Mosher's method and a comparison of their CD spectra with dihydroisocoumarins described in the literature.

Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin.

microRNA (miR)-612 shows anticancer activity in several types of cancers, yet its function in melanoma is still unclear. This study was undertaken to investigate the expression of miR-612 and its biological relevance in melanoma cell growth, invasion, and tumorigenesis. The expression and prognostic significance of miR-612 in melanoma were examined.

Reconstruction of singular eyelid defects in aging individuals based on facial aesthetic subunits.

Background: In consideration of the distinctive structural characteristics of the eyelid, the optimally matching donor site to the original recipient site skin should be selected when a full-thickness skin graft is anticipated in a small-sized or medium-sized eyelid defect in middle-aged or elderly patients.

Methods: Eight patients ranging in age from 47 to 71 years suffered singular eyelid defects of different causes. Based on the location, shape, and degree of the defects, we removed the redundant skin as a skin graft from the same side in the contralateral eyelid in a routine blepharoplasty procedure and transferred the graft to repair the defect.

[Reshaping the nasal tip with autologous nasal septum cartilage combined with ePTFE grafts and autologous auricular cartilage grafts].

Objective: To evaluate the clinical effects of reshaping the nasal tip with autologous nasal septum cartilage combined with expanded polytetrafluoroethylene (ePTFE) and autologous auricular cartilage grafts.

Methods: The nasal septal cartilage combined with ePTFE (group A, 70 cases) and autologous auricular cartilage grafts (group B, 48 cases) were used separately. The therapeutic effect and operation time were compared using the t-test or the χ²-test by the SPSS 12.

Effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension.

Objective: To observe the effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang (平肝潜阳, CGSHY) on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension (EH).

Methods: Adopting a parallel, randomized design, sixty-four patients with EH of stages I and II were randomly divided into two groups according to a random number table, with 32 in each group. The patients in the treatment group were treated with CGSHY and those in the control group were treated with Enalapril.

Malignant cutaneous tumors of the scalp: a study of demographic characteristics and histologic distributions of 398 Taiwanese patients.

Background: The scalp is a unique anatomic region, in which pilosebaceous follicles are concentrated.

Objective: We sought to investigate demographic characteristics and histologic distributions of malignant scalp tumors.

Methods: Primary and metastatic scalp malignancies diagnosed histopathologically between 1983 and 2003 were reviewed.