Mechanisms by which silencing long-stranded noncoding RNA KCNQ1OT1 alleviates myocardial ischemia/reperfusion injury (MI/RI)-induced cardiac injury via miR-377-3p/HMOX1.

Background: The key complication of myocardial infarction therapy is myocardial ischemia/reperfusion injury (MI/RI), and there is no effective treatment. The present study elucidates the mechanism of action of lncRNA KCNQ1OT1 in alleviating MI/RI and provides new perspectives and therapeutic targets for cardiac injury-related diseases.

Methods: An ischemia/reperfusion (I/R) injury model of human adult cardiac myocytes (HACMs) was constructed, and the expression of KCNQ1OT1 and miR-377-3p was determined by RT‒qPCR.

Electrolytic Corrosion Behavior of 20 Cu-20 Ni-54 NiFeO-6 NiO Cermet with Interpenetrating Structure at 880 °C and 960 °C.

Here, 20 Cu-20 Ni-54 NiFeO-6 NiO (wt%) cermets were prepared via the powder metallurgy process, and the electrolytic corrosion behavior of the cermets at 880 °C and 960 °C was studied through the microstructure analysis by SEM and EDS. Results show that the ceramic phase is seriously affected by chemical corrosion at 880 °C electrolysis, and it is difficult to form a dense ceramic surface layer. A dense ceramic surface layer is formed on the bottom of the anode electrolyzed at 960 °C, and the dense layer thickens with the extension of the electrolysis time.