Publications by authors named "Min-Hyun Cho"
Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD.
Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease).
Article Synopsis
- Alport syndrome (AS) is a common inherited kidney disease that requires early diagnosis for better outcomes; this study assessed the awareness and understanding of AS among Korean clinicians, patients, and caregivers.
- An online survey of 103 participants revealed that many clinicians had limited experience with AS and frequently overlooked it as a potential diagnosis, while patients and caregivers expressed concerns about delayed diagnoses and lack of support.
- The findings highlight a gap in the adoption of recent guidelines for AS in clinical practice in Korea, indicating the need for improved recommendations and a registry to enhance patient care.
Background: The natural course of chronic kidney disease (CKD) progression in children varies according to their underlying conditions. This study aims to identify different patterns of subsequent decline in kidney function and investigate factors associated with different patterns of estimated glomerular filtration rate (eGFR) trajectories.
Methods: We analyzed data from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease), which is a longitudinal, prospective cohort study.
Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis.
Kidney Res Clin Pract
December 2023
Article Synopsis
- This study focused on childhood-onset lupus nephritis (LN), examining the clinical features, kidney outcomes, and risk factors related to prognosis in 216 patients across South Korea.
- Most patients presented with nephrotic syndrome or hematuria, and the most common kidney damage was WHO class IV LN, with nearly 15% developing advanced chronic kidney disease (CKD) after an average follow-up of about 8 years.
- Key risk factors identified for advanced CKD included being male and not achieving remission within the first year of treatment, indicating the need for careful monitoring of these patients to improve their long-term outcomes.
Background: Donor-recipient size mismatching is commonly occurs in pediatric kidney transplantation (KT). However, its effect on graft survival remains unknown. This study aimed to determine the effect of donor-recipient size mismatch on the long-term survival rate of transplant kidneys in pediatric KT.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) has spread considerably across the globe, affecting numerous children and adolescents besides adults. Despite its relatively lower incidence rates in children and adolescents than in adults, some infected children and adolescents exhibit a severe postinflammatory response known as multisystem inflammatory syndrome in children, followed by acute kidney injury, a common complication. Meanwhile, few reports have been available regarding kidney complications such as idiopathic nephrotic syndrome and other glomerulopathies associated with COVID-19 infection and vaccination in children and adolescents.
View Article and Find Full Text PDFCorrigendum: Mineral bone disorder in children with chronic kidney disease: data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study.
Front Pediatr
June 2023
[This corrects the article DOI: 10.3389/fped.2023.
View Article and Find Full Text PDFBackground: Dyslipidemia can cause cardiovascular disease and increase the fatality rate among children with chronic kidney disease (CKD); this makes early screening and treatment of dyslipidemia crucial. This study aimed to assess the association between the changes in serum total cholesterol levels over time and the degree of CKD progression in children.
Methods: From April 2011 to August 2021, 379 of the 432 participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-PedCKD) were included and divided into 4 categories based on total cholesterol levels (< 170 mg/dL, acceptable; 170-199, borderline; 200-239, high; and ≥ 240, very high).
Article Synopsis
- Researchers studied 172 people with kidney diseases using a special test called whole exome sequencing (WES) to find genetic problems.
- They discovered that WES could diagnose genetic diseases in 63 of those patients, which is about 36.6%.
- The testing was most helpful for younger patients (under 6 years old), and it even changed the way 10 of the patients were treated after finding their genetic issues.
Article Synopsis
- - This study examined the relationship between genotype and phenotype in X-linked Alport syndrome (XLAS) among 216 Korean patients, finding that males experience earlier onset and more severe kidney failure than females.
- - About 60% of male patients developed kidney failure by the age of 25, with significant differences in kidney survival based on their genetic group, while only 20% of female patients experienced kidney failure by age 50.
- - The results suggest a clear genotype-phenotype correlation in both male and female patients, highlighting the need for better understanding of XLAS in women, who tend to have a later onset of symptoms.
Article Synopsis
- The COVID-19 pandemic has been linked to kidney issues in both adult and pediatric patients, with an 11-year-old boy experiencing acute kidney injury after his infection.
- The boy showed symptoms like blood in urine, high protein levels, and high blood pressure, leading to a diagnosis of crescentic immune-mediated glomerulonephritis via renal biopsy.
- He was treated with medications including prednisolone and cyclophosphamide, and after five weeks of treatment, his kidney function is showing signs of recovery.
This study analyzed survey results regarding awareness of living minors' organ donation. The questionnaires focused on changes in how respondents felt about donations by living minors after eliciting the uncertainty of long-term outcomes for living donors and recipients. The respondents were categorized as minors, adults affiliated with non-medical jobs (Non-Meds), and adults affiliated with medical jobs (Meds).
View Article and Find Full Text PDFMineral bone disorder in children with chronic kidney disease: Data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study.
Front Pediatr
February 2023
Article Synopsis
- Children with chronic kidney disease (CKD) are prone to mineral bone disorder (MBD), which can cause serious health issues like fractures and growth problems, and this study aimed to investigate these conditions in Korean pediatric patients.
- The research analyzed data from 431 children with CKD, measuring various factors related to MBD, including calcium, phosphate, vitamin D levels, and bone density across different stages of CKD.
- Findings showed that abnormalities in mineral metabolism significantly increased as CKD progressed, with higher rates of hyperphosphatemia and hyperparathyroidism, and increased use of medications aimed at managing these issues in advanced stages of the disease.
This study aimed to evaluate the differences in the clinical significance of antinuclear antibody (ANA) according to their titers and patterns in the diagnosis of systemic autoimmune diseases (AiD) in pediatric patients. Of the 2442 children who had undergone an ANA test, 473 (19.4%) were positive for ANA, of whom 33 (7.
View Article and Find Full Text PDFMicroplastics have become a ubiquitous contaminant in the environment. The present study focuses on the identification, characterization, and quantification techniques for tracking microplastics. Due to their unique compositional structure, unambiguous identification of individual polymers in various plastic samples, usually comprised of mixtures of individual polymers, remains a challenge.
View Article and Find Full Text PDFBackground: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races.
Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected.
Clinical outcomes in pediatric patients with normal renal histopathology.
Kidney Res Clin Pract
January 2022
Background: There have been some cases where abnormal histopathologic findings could not be found in the kidney could even with proper specimen collection through percutaneous renal biopsy (PRB) in accordance with its indication. We analyzed the incidence and clinical outcomes of children who showed normal histopathological findings in their PRBs.
Methods: The medical records of 552 pediatric subjects who underwent PRB between 2005 and 2016 were reviewed.
Article Synopsis
- This study focused on pediatric rhabdomyolysis in South Korea, analyzing 880 cases from 23 hospitals to identify characteristics and risk factors related to acute kidney injury (AKI).
- The most affected age group was children aged 3 to 5, with neurological disorders and infections being common causes of rhabdomyolysis, and an 11.3% incidence rate of AKI was noted among the patients.
- Key risk factors for AKI were identified, including multiorgan failure and specific laboratory findings, which could help in early detection and intervention for at-risk pediatric patients.
Article Synopsis
- Chronic kidney disease (CKD) negatively impacts growth and cognitive function in children and adolescents, prompting a study to explore intelligence levels and risk factors among this population.
- In the study involving 81 CKD patients under 18, the average IQ was 91, with 24.7% scoring below 80; factors like short stature, severe CKD stages, and longer illness duration correlated with lower IQs.
- Findings suggest a need for further investigation into cognitive impairment related to growth issues in pediatric CKD patients, with early interventions potentially improving IQ outcomes through treatments like kidney transplantation.
Background: Preserving optimal growth has long been a significant concern for children with chronic kidney disease (CKD). We aimed to examine the incidence of and risk factors for short stature in Asian pediatric patients with CKD.
Methods: We analyzed growth status by height, weight, and body mass index (BMI) standard deviation scores (SDSs) for 432 participants in the KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease.
Article Synopsis
- Cardiovascular disease is the leading cause of death in children with chronic kidney disease (CKD), with left ventricular hypertrophy (LVH) serving as an important early indicator of related heart issues.
- A study examined 244 Korean pediatric CKD patients, using echocardiography to assess left ventricular diastolic dysfunction (LVDD) and its association with LVH.
- Results indicated that 40.1% had LVH, while 4.5% had LVDD, with younger age, low hemoglobin levels, and increased wall thickness being significant risk factors for developing LVDD.
EVIDENCE, an automated variant prioritization system, has been developed to facilitate whole exome sequencing analyses. This study investigated the diagnostic yield of EVIDENCE in patients with suspected genetic disorders. DNA from 330 probands (age range, 0-68 years) with suspected genetic disorders were subjected to whole exome sequencing.
View Article and Find Full Text PDFArticle Synopsis
- Children with nephrotic syndrome (NS) are at a higher risk for acute kidney injury (AKI), and the incidence of AKI in this group is rising, prompting a nationwide study to explore this issue in hospitalized pediatric patients.
- The study involved 363 children with NS who were hospitalized over a five-year period, revealing that 16.2% experienced AKI, predominantly due to long disease duration, low albumin levels, and treatment with methylprednisolone.
- Most AKI cases were reversible, with a small percentage leading to chronic kidney disease; however, those with AKI had longer hospital stays compared to those without it, indicating the clinical significance of monitoring these patients closely.