Publications by authors named "Min-Hsuan Chiang"
Objectives: Oral submucous fibrosis (OSMF) is a chronic inflammatory disease and a potentially malignant oral disorder. However, the best therapeutic treatment for OSMF remains uncertain. Our previous study showed that photobiomodulation (PBM) therapy and forskolin could reduce arecoline-induced fibrosis reactions via the cAMP pathway.
View Article and Find Full Text PDFHyperglycemia-induced inflammation can greatly increase the risk of periodontal disease in people with diabetes. Low-level laser irradiation (LLLI) has been used for wound healing and anti-inflammation in many cases, and LLLI is known to inhibit the lipopolysaccharide (LPS)-stimulated inflammatory response. However, the therapeutic effect of LLLI in diabetes patients with periodontitis remains unknown.
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- Both stem cell therapy and physical treatments are effective in promoting bone healing, but the combined effects of these treatments for large bone defects are not fully understood.
- This study explored the impact of low-power laser irradiation (LPLI) and human adipose-derived stem cells (ADSCs) on bone regeneration using a rat model with critical-sized skull defects.
- Results indicated that both LPLI and ADSC treatments enhanced healing compared to the control group, with the combination of ADSCs and LPLI showing the greatest improvement in bone healing after 16 weeks.
Periodontal disease is a chronic inflammatory disease that is commonly treated with surgical and nonsurgical techniques. However, both approaches have limitations. Low-level laser therapy (LLLT) has been widely applied in reducing inflammatory reactions, and research indicates that LLLT induces an anti-inflammatory effect that may enhance periodontal disease therapy.
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- Oral submucous fibrosis (OSF) is a serious condition linked to arecoline from the areca nut, which causes fibrosis in the mouth.
- This study explores how low-power laser irradiation (LPLI) could help reduce fibrosis caused by arecoline in human gingival fibroblasts (HGFs), by analyzing specific fibrotic marker genes.
- Results showed that LPLI and forskolin effectively lowered the expression of fibrotic markers like CCN2 and α-SMA, suggesting that LPLI may work through the cAMP signaling pathway to reduce fibrosis.
Article Synopsis
- Oral submucous fibrosis (OSF) is a serious mouth condition linked to areca quid chewing, but its molecular causes aren't fully understood due to limited research models.
- A study was conducted to create an animal model using areca nut extract (ANE) to mimic OSF by injecting it into mice and observing changes.
- Results showed that ANE injections led to increased skin thickness and collagen, along with the activation of fibrotic markers, indicating that this model could help in understanding OSF better.