CD8CD28/CD8CD28 T cell equilibrium can predict the active stage for patients with inflammatory bowel disease.

Background/aim: The balance of blood CD8CD28/CD8CD28 T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate the efficiency of the balance in predicting the active stage in IBD patients.

Methods: Fifty-three IBD subjects, including 31 UC and 22 Crohn's disease (CD) patients, were enrolled, and their peripheral blood CD8CD28 and CD8CD28 T cell levels were tested using flow cytometry.

[Immunological balance of CD8CD28/CD8CD28 T lymphocytes can predict gastrointestinal hemorrhage in patients with inflammatory bowel disease].

Objective: To evaluate the sensitivity and specificity of CD8CD28/CD8CD28 T lymphocyte balance in predicting the gastrointestinal hemorrhage (GH) in patients with inflammatory bowel disease (IBD).

Methods: Forty-nine IBD patients, including 30 with ulcerous colitis (UC) and 19 with Crohn's disease (CD), were enrolled to test peripheral blood CD8CD28 and CD8CD28 T cells using flow cytometry. All the patients were followed up for one year.

Effects of chronic multiple stress on learning and memory and the expression of Fyn, BDNF, TrkB in the hippocampus of rats.

Background: The effect of chronic stress on cognitive functions has been one of the hot topics in neuroscience. But there has been much controversy over its mechanism. The aim of this study was to investigate the effects of chronic multiple stress on spatial learning and memory as well as the expression of Fyn, BDNF and TrkB in the hippocampus of rats.

[Chronic multiple stress enhances learning and memory capability in rats].

The present study aimed at investigating the effects of chronic multiple stress on learning and memory functions of rats. Adult male Wistar rats were randomly divided into stressed and control groups. Rats in the stressed group were irregularly and alternately exposed to the situation of vertical revolution, sleep deprivation, noise stimulation, and night illumination 6 h per day for 6 weeks to prepare a chronic multiple stressed model.