sp. nov., sp. nov. and sp. nov., isolated from coastal environments.

Three bacterial strains, namely LPB0304, LPB0319 and LPB0142, were isolated from coastal environments. The 16S rRNA gene sequences of the three isolates were found to show the highest sequence similarities to (98.44 %), (97.

Multi-omics analysis of Gwakhyangjeonggi-san for gastrointestinal complications in atopic dermatitis: A randomized, double-blinded, placebo-controlled, parallel-group clinical trial.

Ethnopharmacological Relevance: In traditional Chinese medicine (TCM) and traditional Korean medicine (TKM), Gwakhyangjeonggi-san (GJS) is an herbal decoction used to treat gastrointestinal disorders and allergic diseases. However, no randomized controlled trials have reported the efficacy and safety of GJS against atopic dermatitis (AD) or its comorbidities.

Aim Of The Study: This clinical trial investigated the clinical efficacy and safety of GJS for treating patients with AD who have gastrointestinal symptoms, using a multi-omics approach that included 16S rRNA sequencing and metabolomics.

Subspecies-level genome comparison of Lactobacillus delbrueckii.

Lactobacillus delbrueckii comprises six subspecies, L. delbrueckii subsp. bulgaricus, L.

Peripheral blood transcriptomic clusters uncovered immune phenotypes of asthma.

Background: Transcriptomic analysis has been used to elucidate the complex pathogenesis of heterogeneous disease and may also contribute to identify potential therapeutic targets by delineating the hub genes. This study aimed to investigate whether blood transcriptomic clustering can distinguish clinical and immune phenotypes of asthmatics, and microbiome in asthmatics.

Methods: Transcriptomic expression of peripheral blood mononuclear cells (PBMCs) from 47 asthmatics and 21 non-asthmatics was measured using RNA sequencing.

Effect of luxS encoding a synthase of quorum-sensing signal molecule AI-2 of Vibrio vulnificus on mouse gut microbiome.

Autoinducer-2 (AI-2), a quorum-sensing signal molecule from the human pathogen Vibrio vulnificus, was assessed for its effect on the gut microbiome of mice. For this, we employed 16S rRNA sequencing to compare the gut microbiome of mice infected with either wild-type V. vulnificus or with the isotype ΔluxS that has a deletion in luxS which encodes the biosynthetic function of AI-2.

Distribution of bacteriocin genes in the lineages of Lactiplantibacillus plantarum.

Lactiplantibacillus plantarum, previously named "Lactobacillus plantarum," is found in a wide variety of environments exhibiting a high level of intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses of the 54 complete genome sequences. The results revealed that L.

Modulation of the Gut Microbiota by - Shapes the Immune Responses of Atopic Dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex immune dysregulation and closely related to the gut microbiome. The present study investigated the microbiome-mediated effect of (SHCGT) on AD-like symptoms induced by 2,4-dinitrochlorobenzene (DNCB) in BALB/c mice. DNCB was applied regularly to the ear and dorsal skin of BALB/c mice, and SHCGT was administered orally daily for 2 weeks.

VicPred: A Genotype Prediction Tool.

Genomic information can be used to predict major pathogenic traits of pathogens without the need for laboratory experimentation. However, no genome-based trait identification tools currently exist. The aim of this study was to develop a web-based prediction tool to identify pathogenic traits using publicly available 796 whole-genome sequences of .

Interactions between NCRILC3s and the Microbiome in the Airways Shape Asthma Severity.

Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote asthma, little is known about the relationship between the recently discovered lung microbiome and asthma. Innate lymphoid cells (ILCs) have also been shown recently to participate in asthma.

Association of obstructive sleep apnea severity with the composition of the upper airway microbiome.

Study Objectives: Although the airway mucosal system plays a pivotal role in the pathogenesis of obstructive sleep apnea (OSA), the underlying disease mechanism remains unclear. The microbiome greatly impacts human health and disease, particularly in the mucosa, where it can have direct interactions. In this study, we aimed to analyze the microbiome composition in the upper airway mucosa of individuals with and without OSA to identify potential disease severity-related microbial signatures.

Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation.

Background: Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nursing home residents with a poor functional status, or recent (past 90 days) hospitalization or recent (past 180 days) antibiotic therapy.

sp. nov., isolated from a squid.

A Gram-stain-negative, aerobic, short rod-shaped, motile, brownish-coloured bacterium, termed strain LPB0137, was isolated from a squid. Its cells could grow weakly on marine agar 2216 with 0.04 % 2,3,5-triphenyl tetrazolium chloride (TTC).

Alteration of Lung and Gut Microbiota in IL-13-Transgenic Mice Simulating Chronic Asthma.

Increasing evidence suggests a potential role of microbial colonization in the inception of chronic airway diseases. However, it is not clear whether the lung and gut microbiome dysbiosis is coincidental or a result of mutual interaction. In this study, we investigated the airway microbiome in interleukin 13 (IL-13)-rich lung environment and related alterations of the gut microbiome.

sp. nov., sp. nov. and sp. nov., isolated from the Namhangang River system.

Three bacterial strains, namely HYN0069, HYN0085 and HYN0086, were isolated from freshwater samples taken from the Namhangan River system in Korea. 16S rRNA gene sequence similarities and phylogenetic tree topologies indicated that the three strains belonged to the genera , and by showing the highest sequence similarities with (98.4 %), (98.

sp. nov., isolated from sea water.

A Gram-stain-negative, yellow-pigmented, aerobic bacterial strain, designated LPB0140, was isolated from sea water. The 16S rRNA gene sequence similarity analysis demonstrated that the closest relative of the isolate is (96.4 %), but the new isolate formed an independent phyletic line within the genus Its genome is composed of a circular chromosome of 2.