Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function.

Phosphatidylserine (PS) is an integral component of eukaryotic cell membranes and organelles. The genome contains a single PS synthase (PSS)-encoding gene () homologous to mammalian PSSs. Flies with loss-of-function alleles show a reduced life span, increased bang sensitivity, locomotor defects, and vacuolated brain, which are the signs associated with neurodegeneration.