miR-21-5p Targets PIK3R1 to Regulate the NF-B Signaling Pathway, Inhibiting the Invasion and Progression of Prolactinoma.

Prolactinomas (PRLs) are benign tumors with malignant characteristics that can invade the surrounding tissue structures and are challenging to treat. It has been reported that miR-21-5p expression in pituitary adenomas is correlated with tumor invasion and size. However, the mechanism of action of miR-21-5p in PRL remains unclear.

The eagle sign: a new preoperative MRI-based tool for predicting topographic correlation between craniopharyngioma and hypothalamus.

Purpose: Accurate prediction of topographical correlation between craniopharyngiomas (CPs) and hypothalamus is important for treatment. This study sought to develop a predicting tool based on preoperative-MRI through radiological-surgical-pathological-outcome analysis.

Materials And Methods: Third ventricle floor (TVF), mammillary bodies and cerebral peduncle were evaluated through preoperative-MRI.