Metal-Like Conductivity in Acid-Treated PEDOT:PSS Films: Surpassing 15,000 S/Cm.

Although poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) films with high conductivity have been obtained through conventional organic solvent and acid treatment, their conductivity has not yet exceeded 10000 S/cm. In this paper, by combining blade-coating and treating with high concentration and volatilizable trifluoromethanesulfonic acid (CFSOH), PEDOT:PSS films with ultrahigh conductivity of 15143 S/cm, comparable to some metals, were prepared. Characterizations of morphology and structure indicate the formation of a perfectly continuous fibrous network structure, highly oriented crystallization, and tightly packed π-π stacking of PEDOT chains after removing a vast amount of PSS, which contributes to boosting the electrical conductivity of the treated PEDOT:PSS film.

DPHB inhibits osteoclastogenesis by suppressing NF-κB and MAPK signaling and alleviates inflammatory bone destruction.

Overactivation of osteoclasts disrupt the delicate balance between bone-resorbing osteoclasts and bone-forming osteoblasts, resulting in development of osteoporosis and various inflammatory disorders, including rheumatoid arthritis, spondyloarthropathies, and psoriatic arthritis. While inhibiting osteoclastogenesis represents a promising therapeutic strategy, current treatments targeting the RANKL pathway (such as bisphosphonates and denosumab) are associated with severe side effects, necessitating the development of safer alternatives. We hypothesize that the compound (4E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB), derived from Alpinia officinarum Hance, can effectively inhibit RANKL-induced osteoclastic activity while maintaining a favorable safety profile.

UFMylation maintains YAP stability to promote vascular endothelial cell senescence.

Endothelial cell (EC) senescence is an accomplice for vascular aging, which leads to cardiovascular diseases (CVDs). Evidences showed that Hippo-Yes-associated protein (YAP) signaling pathway plays an essential role in aging-associated CVDs. Here, we reported that YAP was elevated in senescent human umbilical vein endothelial cells (HUVECs) and inhibition of YAP could attenuate HUVECs senescence.

Computational approaches for decoding structure-saltiness enhancement and aroma perception mechanisms of odorants: From machine learning to molecular simulation.

The unclear relationship between structure and saltiness enhancement limits the development and application of savory odorants. The structure characteristic-saltiness enhancement perception (SEP) mechanisms of savory odorants were investigated by machine learning, molecular docking, and site-directed mutagenesis simulations. The XGBoost model (R = 0.

BRISC-Mediated PPM1B-K63 Deubiquitination and Subsequent TGF-β Pathway Activation Promote High-Fat/High-Sucrose Diet-Induced Arterial Stiffness.

Background: Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)-induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg/Mn-dependent 1B)-lysine 63(K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness.

Effectively saltiness enhanced odorants screening and prediction by database establish, sensory evaluation and deep learning method.

Odor-taste interaction has gained success in enhancing saltiness perception. This work aimed to provide candidate odorants for saltiness enhancement. Volatile compounds and their frequencies in salty foods were systematically analyzed.

Impact of magnetic field-assisted freezing on the physicochemical properties and starch structure of cooked rice: Effects of magnetic types, intensities, and cryostasis time.

A magnetic field-assisted freezing system was developed to mitigate the degradation of taste quality in frozen cooked rice (FCR). The physicochemical properties and starch structure were analyzed under varying magnetic field types, intensities, and cryostasis time. The analysis of freezing characteristics indicated that treatments with 10 mT static magnetic fields (SMF) and 6 mT alternating magnetic fields (AMF) yielded optimal results, significantly reducing the duration of the maximum ice crystal generation zone by approximately 18 min.

SAT1/ALOX15 Signaling Pathway Is Involved in Ferroptosis After Skeletal Muscle Contusion.

Skeletal muscle contusion (SMC) is common in daily life and clinical practice, but the molecular mechanisms underlying SMC healing are unclear. Ferroptosis, a regulated cell death type, has gained attention recently. We observed iron overload in skeletal muscle following contusion through HE and Perls staining.

The mediating role of systemic inflammation in the association between bedroom light at night and new-onset depressive symptoms among Chinese young adults: A prospective cohort study.

Background: The detrimental effects of exposure to light at night (LAN) have received increasing attention. However, the effects of LAN exposure on depressive symptoms and underlying mechanism are less explored.

Objectives: To investigate the association between LAN exposure with new-onset and trajectories of depressive symptoms, and the potential mediating role of systemic inflammation.

Intergenerational continuation of parent-child separation and 1-year telomere length attrition among mother-offspring dyads in rural China: The moderating effects of resilience.

Background: Although stressor exposure early in life was known risk factor for telomere length (TL) attrition, limited literature explored it across generations. Furthermore, the effects of resilience have rarely been examined. Here, we examined whether the effects of intergenerational parent-child separation on offspring 1-year TL attrition vary by the levels of resilience.

Lifestyle-specific association between adversity dimensions with group-based mental health trajectories.

Background: Childhood adversity (CA) has a substantial correlation with mental health problems. Keeping a healthy lifestyle is essential for mental health interventions; it is unclear, however, how healthy lifestyle affect the relationship between CA and persistent mental health problems.

Methods: This longitudinal study (n = 1112, 54.

Integrative Analysis of Multi-Omic Data for the Characteristics of Endometrial Cancer.

Endometrial cancer (EC) is a frequently diagnosed gynecologic cancer. Identifying reliable prognostic genes for predicting EC onset is crucial for reducing patient morbidity and mortality. Here, a comprehensive strategy with transcriptomic and proteomic data was performed to measure EC's characteristics.

Construction of a Soft Antifouling PAA/PSBMA Hydrogel Coating with High Toughness and Low Swelling through the Dynamic Coordination Bonding Provided by Al(OH) Nanoparticles.

Marine biofouling, resulting from the adhesion of marine organisms to ship surfaces, has long been a significant issue in the maritime industry. In this paper, we focused on utilizing soft and hydrophilic hydrogels as a potential approach for antifouling (AF) coatings. Acrylic acid (AA) with a polyelectrolyte effect and -(3-sulfopropyl)--(methacryloxyethyl)-,-dimethylammonium betaine (SBMA) with an antipolyelectrolyte effect were selected as monomers.

Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma.

The role of Epstein-Barr virus (EBV) in lymphoma cells of nodular sclerosis classic Hodgkin lymphoma (NScHL) is controversial. Our aim was to explore this and establish a clinically feasible model for risk stratification. We interrogated data from 542 consecutive subjects with NScHL receiving ABVD therapy and demonstrated EBV-infection in their lymphoma cells with EBV-encoded small RNAs (EBERs) hybridization.

Advancing document-level event extraction: Integration across texts and reciprocal feedback.

The primary objective of document-level event extraction is to extract relevant event information from lengthy texts. However, many existing methods for document-level event extraction fail to fully incorporate the contextual information that spans across sentences. To overcome this limitation, the present study proposes a document-level event extraction model called Integration Across Texts and Reciprocal Feedback (IATRF).

Stepwise Alloying in Liquid-like Solid Solutions to Achieve Crystallographic Distortion for Regulating Thermoelectric Transport Behavior.

With the surge of energy consumption, environmental-protection CuSe thermoelectric materials are increasingly attracting attention. In this work, multilayered structures are constructed in CuSe solid solutions by alloying (SnSe)(AgBiSe), which strongly scatters full-wavelength phonons by carefully regulating the crystallographic distortion. By using the stepwise alloying strategies, crystallographic distortion and the resultant strain fields presented in microstructure were strengthened markedly, which enhanced the phonon scattering.

The role of polysaccharides in improving the functionality of zein coated nanocarriers: Implications for colloidal stability under environmental stresses.

Zein has gained popularity over the past few years as an incredible food and bio-based materials. The potential functions and health benefits of zein microcapsules or micro-/nanoparticles in bioactive components delivery, structured emulsion, etc., have received great attention.

Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis.

Aims: The manipulation of macrophage recruitment and their shift in the M1/M2 ratio is a promising approach to mitigate osteoarthritis (OA). Nevertheless, the current clinical medication available for OA is only palliative and may result in undesirable outcomes. Hence, it is urgent to explore alternative disease-modifying drug supplement that are both safer and more effective in OA treatment, like probiotic and probiotic-derived membrane vesicles.

(5R)-5-hydroxytriptolide for HIV immunological non-responders receiving ART: a randomized, double-blinded, placebo-controlled phase II study.

Background: Therapeutic approaches to HIV-suppressed immunological non-responders (INRs) remain unsettled. We previously reported efficacy of Chinese herbal Tripterygium wilfordii Hook F in INRs. Its derivative (5R)-5-hydroxytriptolide (LLDT-8) on CD4 T cell recovery was assessed.

Autoformer-Based Model for Predicting and Assessing Wheat Quality Changes of Pesticide Residues during Storage.

Proper grain storage plays a critical role in maintaining food quality. Among a variety of grains, wheat has emerged as one of the most important grain reserves globally due to its short growing period, high yield, and storage resistance. To improve the quality assessment of wheat during storage, this study collected and analyzed monitoring data from more than 20 regions in China, including information on storage environmental parameters and changes in wheat pesticide residue concentrations.

FEDformer-Based Paddy Quality Assessment Model Affected by Toxin Change in Different Storage Environments.

The storage environment can significantly impact paddy quality, which is vital to human health. Changes in storage can cause growth of fungi that affects grain quality. This study analyzed grain storage monitoring data from over 20 regions and found that five factors are essential in predicting quality changes during storage.

Toughening Hydrogels by Forming Robust Hydrazide-Transition Metal Coordination Complexes.

Energy dissipation based on dynamic fracture of metal ligands is an effective way to toughen hydrogels for specific applications in biomedical and engineering fields. Exploration of new kinds of metal-ligand coordinates with robust bonding strength is crucial for the facile synthesis of tough gels. Here a hydrogel toughening strategy based on the formation of robust coordination complexes between the hydrazide ligands and zinc ions is reported.