A proposal to simplify the definition of pediatric hypertension: bridging the gap between perception and action.

Background: The importance of routine hypertension screening in children and adolescents is now well recognized. However, it is often undiagnosed in clinical practice, partly due to the reliance on a complex blood pressure (BP) percentile-based table with hundreds of cutoffs by age, sex, and height.

Main Text: Many studies have explored simplified tools for screening hypertension in children and adolescents, such as simplified formulas, simplified BP tables by age and sex group, by age group, or by height group, and the BP to height ratio.

Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study.

Objective: This study aims to assess the safety and effectiveness of High-Intensity Focused Ultrasound (HIFU) ablation on pregnancy outcomes among women with uterine fibroids wishing to conceive, focusing specifically on short-term pregnancy outcomes immediately following HIFU treatment.

Methods: A retrospective analysis was conducted on 210 women who underwent HIFU treatment (Group I) at our institution between January 2018 and December 2022 and subsequently conceived. Pregnancy outcomes were compared with two control groups: 510 patients who delivered vaginally (Group II) and 278 who underwent cesarean sections (Group III) during the same period.

Neurophysiological correlates of trait and behavioral impulsivity across methamphetamine and gambling Addiction.

Investigating neurophysiological markers linked to impulsivity in individuals with gambling and methamphetamine addiction using resting-state EEG data offers valuable insights into the underlying neurophysiological mechanisms associated with impulsivity in individuals with addiction. This study aims to use resting-state EEG to explore the connection between various types of addiction and different aspects of impulsivity. Participants from the methamphetamine, gambling, and healthy control groups (abbreviation: MA, GB, HC) underwent EEG recordings and completed measures of impulsivity.

Fast Colorimetric Detection of HO and Glucose: A Way Based on Magnetic Nanoparticles Composed of Fe(PO)·8HO Isolated from CG-1.

In this study, Fe(PO)·8HO magnetic nanoparticles (MNPs) were successfully extracted from the strain CG-1. We subsequently characterized their composition, structure, and morphology, revealing that these nanoparticles consisted of Fe(PO)·8HO with an average diameter of 66.87 ± 0.

Genetic profile in primary tumor tissue of advanced lung adenocarcinoma patients with adrenal metastasis.

The aim of this study was to examine the genomic characteristics and explore the molecular mechanisms underlying adrenal metastases in lung adenocarcinoma. 57 patients diagnosed with lung adenocarcinoma (LUAD) and adrenal metastases (AM) were enrolled, alongside 33 controls diagnosed with non-adrenal metastases (non-AM) at the time of diagnosis. The primary lung cancer tissue sample were analyzed using next-generation sequencing.

American ginseng vesicles loaded hyaluronic acid hydrogel for ulcerative colitis.

The present study introduces a novel therapeutic approach for ulcerative colitis (UC) utilizing American ginseng vesicles encapsulated within a hyaluronic acid (HA) hydrogel matrix. UC, a prevalent form of inflammatory bowel disease, is characterized by chronic inflammation of the colonic mucosa, leading to significant morbidity and compromised quality of life. Existing therapeutic modalities such as 5-Aminosalicylic acid (5-ASA) are associated with substantial side effects and a high recurrence rate.

Tardigrades in the alpine region of Northeast China with an integrative description of Crenubiotus liangshuiensis sp. nov.

A new species of tardigrade, Crenubiotus liangshuiensis sp. nov. (Eutardigrada: Parachela: Macrobiotoidea: Adorybiotidae), was identified by combining DNA barcoding and classical morphological analyses (including both light contrast microscopy and scanning electron microscopy) of animals and an egg found in moss Collected in Yichun Liangshui National Nature Reserve.

Thinning of central foveal thickness in the retina of patients with schizophrenia.

The neural retina shares a common embryonic origin with the brain and yields pathological changes like that in the brain in various neuropsychiatric disorders, including schizophrenia. Non-invasive examination by optical coherence tomography (OCT) revealed retinal structure abnormalities in patients with schizophrenia. This study investigated retina structures in 29 patients with schizophrenia and 25 healthy controls in a Chinese Han ethnic population with spectral domain OCT.

Milliscale Shape-Programmable Magnetic Machines Based on Modular Janus Disks.

Through billions of years of evolution, small and microorganisms have come to possess distinctive shape-morphing abilities to live in complex fluid environments. However, fabricating milliscale programmable machines with shape-morphing ability often involves complicated architectures requiring arduous fabrication processes and multiple external stimuli. Here, milliscale programmable machines with reconfigurable structures and extensible sizes are proposed based on the sequential assembly of simple Janus disks at liquid surfaces.

Does H3K27me3 expression play a role in patients with Blastic plasmacytoid dendritic cell neoplasm? A clinicopathologic analysis of 14 patients.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive lymphohematopoietic malignancy associated with poor prognosis. We aimed to improve the understanding of BPDCN, explore its prognostic significance, and identify potential therapeutic targets. Data from 14 BPDCN patients were retrospectively collected and analyzed, focusing on their clinicopathological characteristics, diagnostic features, immunophenotype, treatment regimens, and prognostic factors.

Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology.

Pancreatic islets are 3D micro-organs that maintain β-cell functionality through cell-cell and cell-matrix communication. While primary islets, the gold standard for in vitro models, have a short culture life of approximately 1-2 weeks, we developed a novel protocol that employs reformed islets following dispersion coupled with a fine-tuned culture environment. Reformed islets exhibit physiological characteristics similar to primary islets, enabling high-resolution imaging and repeated functional assessment.

Promoting appropriate medication use by leveraging medical big data.

According to World Health Organization statistics, inappropriate medication has become an important factor affecting the safety of rational medication. In the gray area of medical insurance supervision, such as designated drugstores and medical institutions, there are lots of inappropriate medication phenomena regarding "big prescription for minor ailments." A traditional clinical decision support system is mostly based on established rules to regulate inappropriate prescriptions, which are not suitable for clinical environments and require intelligent review.

Toll-like receptor-4 expression and oxidative stress in ocular rosacea.

Purpose: To investigate systemic and ocular toll-like receptor (TLR)-4 expression and its association with oxidative stress markers in ocular rosacea (OR).

Methods: This prospective study included 40 patients with rosacea with ocular involvement and 20 healthy volunteers. Tear break-up time (TBUT), Schirmer test, meibomoscore, and ocular surface disease index (OSDI) scores were estimated for all participants.