Publications by authors named "Min Zhan Kuo"
Purpose: Epigenetic modifications, such as aberrant DNA methylation, histone alterations, non-coding RNA remodeling, and modulation of transcription factors, are pivotal in the pathogenesis of diverse malignancies. Reactive oxygen species (ROS) have the capacity to impact these epigenetic mechanisms, including DNA methylation, throughout the different stages of cancer development. Therefore, the aim of this review is to address the impact of.
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- The study focused on the effects of two compounds, Cryptotanshinone (CPT) and dihydrotanshinone (DHT), from traditional Chinese medicine on cell signaling pathways via changes in microRNA (miRNA).
- Researchers found that both CPT and DHT influence cell proliferation and apoptosis by altering specific miRNAs, with DHT showing potentially stronger effects than CPT in terms of regulating these pathways.
- The conclusion suggests that DHT is a promising candidate for cancer prevention due to its potency and lower toxicity compared to CPT, highlighting its potential role in natural medicine.