The Loss of HJV Aggravates Muscle Atrophy by Promoting the Activation of the TβRII/Smad3 Pathway.

Hemojuvelin (HJV) is a membrane-bound protein prominently expressed in the skeletal muscle, heart, and liver. Despite its established function in iron regulation, the specific role of HJV in muscle physiology and pathophysiology is not well understood. In this study, we explored the involvement of HJV in disuse-induced muscle atrophy and uncovered the potential mechanisms.

Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.

Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers and potentially overlooking novel ones predictive of therapy response. In this work, we develop a novel machine-learning approach capable of exploring full landscape of mutations and combinations and identify potentially new predictive biomarkers for chemoimmunotherapy. Utilizing the liquid biopsy dataset from 313 non-small cell lung cancer (NSCLC) patients in the Phase 3 Impower150 trial (NCT02366143), we developed the HRdiffRF algorithm with a novel hazard ratio-splitting criterion.

Pyrylium derivatives as outer membrane permeabilizers against MDR gram-negative bacteria via multi-target mode of action.

The prevalence of MDR Gram-negative bacteria has posed a great impetus for the discovery of new therapeutic approaches. Here, we synthesized a series of pyrylium derivatives as antibiotic adjuvants based on IMB-0042, and evaluated their activities against Acinetobacter baumannii (A. baumannii) and Escherichia coli (E.

Electrocatalytic Hydrogenation Boosted by Surface Hydroxyls-Modulated Hydrogen Migration over Nonreducible Oxides.

The migration of atomic hydrogen species over heterogeneous catalysts is deemed essential for hydrogenation reactions, a process closely related to the catalyst's functionalities. While surface hydroxyls-assisted hydrogen spillover is well documented on reducible oxide supports, its effect on widely-used nonreducible supports, especially in electrocatalytic reactions with water as the hydrogen source, remains a subject of debate. Herein, a nonreducible oxide-anchored copper single-atom catalyst (Cu/SiO) is designed and uncover that the surface hydroxyls on SiO can serve as efficient transport channels for hydrogen spillover, thereby enhancing the activated hydrogen coverage on the catalyst and favoring the hydrogenation reaction.

Albumin Promotes the Absorption of Pb in the Intestine: A Possible Pathway Linking to the High Absorption of Pb in Adolescence.

High blood lead (Pb) levels have long been a significant environmental issue affecting the health and development of adolescents. However, the main reasons behind this phenomenon, especially the absorption and transportation processes of Pb in the intestine, have not been elucidated, which is the major barrier to reducing blood Pb levels in the human body, especially in adolescents. In this study, we explored the intestinal absorption process of Pb in rats of different ages at environmentally relevant concentrations.

Timosaponin AIII Enhances Radiosensitivity in Breast Cancer through Induction of ROS-Mediated DNA Damage and Apoptosis.

Breast cancer is a commonly diagnosed cancer, while resistance to radiation therapy remains an important factor hindering the treatment of patients. Timosaponin AIII (Tim AIII) is a steroidal saponin from the Anemarrhena asphodeloides. Its pharmacologic effects and mechanisms for enhancing radiotherapy remain largely unknown.

Epidemiological and Spatiotemporal Clustering Analysis of Human Brucellosis - China, 2019-2023.

What Is Already Known About This Topic?: The number of reported cases of human brucellosis significantly increased from 45,046 (3.25/100,000) in 2019 to 70,439 (4.99/100,000) in 2023.

Global Species/Biovars and Genotype Diversity Atlas of spp. - 102 Countries, 1923-2020.

What Is Already Known About This Topic?: spp. are facultative intracellular bacteria that can infect many species of animals and humans.

What Is Added By This Report?: The global demonstrates distinct territorial distribution patterns: predominantly in Africa and North America, dominates in Asia and Europe, and is most prevalent in Europe.

Web of Science-Based Visualization of Metabolic Dysfunction-Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study.

Background And Aims: The prevalence of metabolism-associated fatty liver disease (MAFLD) in children is on the rise. This study employs visualization and analysis to evaluate the research implications, current advancements, and emerging trends in pediatric MAFLD, with the aim of elucidating its pathogenesis and informing the development of clinical treatment strategies.

Methods: Using visualization software, we conducted a visual analysis and mapping of the journal distribution, leading institutions, prominent authors, annual publication trends, and keyword frequencies among the 1179 scholarly articles retrieved from the Web of Science Core Collection for this study.

Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway.

Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. However, the fundamental mechanism underlying myocardial necroptosis, especially the mitochondria-dependent death pathway, is poorly understood. Synaptotagmin-1 (Syt1), a Ca sensor, is originally identified in nervous system and mediates synchronous neurotransmitter release.

Sleep patterns and cardiovascular disease risk in US participants: a comprehensive analysis.

Background And Purpose: To evaluate the association between sleep-related factors, including sleep duration, self-reported sleep disturbances, and diagnosed sleep disorders, and the risk of cardiovascular disease (CVD) in US participants.

Methods: The data of this study from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2014. Sleep factors were assessed using a standardized questionnaire, and overall sleep scores were calculated on a scale of 0 to 3.

Synthesis, biological evaluation and validation of IMB-881 derivatives as anti-Gram-negative bacterial agents.

Infectious diseases caused by drug-resistant bacteria represent one of the most significant global public challenges of this century. There is an urgent need for the treatment of drug-resistant Gram-negative bacterial infections. A series of 3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline derivatives were synthesized and evaluated for their antibacterial activity against Gram-negative bacteria including strains from ATCC and clinical isolates, initially revealing the structure-activity relationship.

Longitudinal genomic profiling using liquid biopsies in metastatic nonsquamous NSCLC following first line immunotherapy.

Tumor genomic profiling is often limited to one or two timepoints due to the invasiveness of tissue biopsies, but longitudinal profiling may provide deeper clinical insights. Using ctDNA data from IMpower150 study, we examined genetic changes in metastatic non-squamous NSCLC post-first-line immunotherapy. Mutations were most frequently detected in TP53, KRAS, SPTA1, FAT3, and LRP1B at baseline and during treatment.

Nanogel imprinting improving affinity and selectivity of domain-limited ssDNA aptamer to Pb: Interaction mechanisms revealed by molecular dynamics simulation.

Aptamer conformations are susceptible to environmental conditions, which makes it difficult to achieve stable targets detection in complex environments with aptasensors. Imprinting strategy was proposed to immobilize the specific conformation of aptamers, aiming to enhance their recognition anti-interference. However, it is mechanistically unclear how the imprinted polymers affect aptamers' recognition, which limits application of the strategy.

pH-dependent cadmium binding to hemoglobin: Implications for human excretion.

Half-life of cadmium (Cd) in blood is around 3-4 months, which is much shorter than its half-life in human organs (30 years). Promoting the elimination of Cd from the blood is a crucial step in reducing the body's Cd burden. However, there is currently no effective method available to facilitate this process.

The selection of target areas for orbital imaging, application of diethylenetriaminepentaacetic acid orbital imaging, clinical factors, alkaline phosphatase, and thyrotropin receptor antibodies in the staging and grading of thyroid-associated ophthalmopathy.

Purpose: This study aimed to investigate the active phase of thyroid-associated ophthalmopathy (TAO), its correlations with clinical factors, serological tests, and orbital imaging parameters, and evaluate the diagnostic value of different orbital imaging target areas.

Methods: A total of 45 patients with thyroid-related eye disease underwent imaging, serological tests, and clinical data collection. Clinical Activity Score (CAS) assessment, diplopia scores, and NOSPECS grading were conducted.

Research on Fault Prediction of Power Devices in Rod Control Power Cabinets Based on BiTCN-Attention Transfer Learning Model.

The Insulated Gate Bipolar Transistor (IGBT) is the key power device in the rod control power cabinet of nuclear power plants; its reliable operation is of great significance for ensuring the safe and economical operation of the nuclear power plants. Therefore, it is necessary to conduct fault prediction research on IGBT to achieve better condition-based maintenance and improve its operational reliability. However, power cabinets often operate under multiple, complex working conditions, so predicting IGBT faults from single working condition data usually has limitations and low accuracy.

Evaluation of the Effects of Guizhi Shaoyao Zhimu Decoction on Rheumatoid Arthritis by Ultrasound Combined with Electrophysiological Examination.

Background: Guizhi Shaoyao Zhimu Decoction can be used in the treatment of rheumatoid arthritis, but there is scarce literature on using ultrasound combined with electrophysiology to evaluate the efficacy of this traditional Chinese medicine.

Aim: This study aimed to explore the clinical effect of Guizhi Shaoyao Zhimu decoction on cold-dampness arthralgia rheumatoid arthritis (RA) by ultrasound and electrophysiological examination.

Methods: A total of 64 patients with rheumatoid arthritis were randomly divided into two groups, with 32 cases in each group.

Longitudinal changes in plasma Cystatin C and all-cause mortality risk among the middle-aged and elderly Chinese population.

Objective: Elevated plasma Cystatin C levels are associated with an increased mortality risk among middle-aged and elderly Chinese individuals. This study explores whether tracking the longitudinal changes in Cystatin C can improve the prediction of mortality risk and allow better risk stratification, jointly with baseline measurements.

Design & Methods: This analysis includes 3,195 participants from the China Health and Retirement Longitudinal Study who completed plasma Cystatin C measurements in two waves (2011 and 2015) and were followed through 2020.

Retrospective Analysis of the Epidemiological Evolution of Brucellosis in Animals - China, 1951-1989 and 1996-2021.

Brucellosis poses a significant threat to public health in China. This study utilized a range of epidemiological indices, including seroprevalence and the number of reported cases, to illustrate the epidemic profile of the disease. Although the seroprevalence of brucellosis in animals (including sheep, goats, cattle, and swine) steadily decreased from a severe epidemic level in the 1950s to a low endemic level by 1989, the disease reemerged in 2000.

VCPIP1 negatively regulates NF-κB signaling pathways by deubiquitinating and stabilizing Erbin in MDP-stimulated macrophages.

Macrophages are present in all tissues and body compartments under homeostatic physiological conditions. Importantly, they play a key role in pathological inflammatory processes when disturbed. They can quickly produce large amounts of inflammatory cytokines in response to danger signals.

Risk assessment of developmental and neurotoxicity by the flavoring agent perillaldehyde: NAC (N-acetylcysteine) mitigation of oxidative stress-mediated inhibition of the Nrf2 pathway.

Perillaldehyde (PAE), a prevalent flavoring agent, has raised safety concerns due to conflicting evidence regarding its toxicity. This study provides a comprehensive assessment of the developmental and neurotoxic effects of PAE in zebrafish, elucidating the underlying mechanisms of its toxicity. Results showed that PAE affected the viability and hatching rate of zebrafish at 96 h postfertilization with the 50 % lethal concentration (LC50) of 7.

An inverted tetrahedron-mediated DNA walker for sulfadimethoxine detection.

An inverted DNA tetrahedron-mediated modular DNA walker was developed for the determination of sulfadimethoxine. The inverted DNA tetrahedron scaffold raises several advantages of recognition module including appropriate lateral space, multiple recognition domains, and cost-effectiveness. The proposed inverted DNA tetrahedron-based recognition module exhibited better binding affinity and kinetics toward target antibiotic than that of other DNA tetrahedron counterparts.