Deciphering the prognostic potential of a necroptosis-related gene signature in head and neck squamous cell carcinoma: a bioinformatic analysis.

Background: Necroptosis, an alternative mode of programmed cell death (PCD) that overcomes apoptosis resistance, has been implicated in the progression and drug resistance of cancer. The aim of this study is to find the biological and prognostic significance of necroptosis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: Integrated clinical datasets from The Cancer Genome Atlas (TCGA) HNSCC cohort underwent analysis.

[Mechanism of electroacupuncture at "Zusanli" (ST36) in improving cardiac function in mice with chronic heart failure].

Objectives: To observe the effect of electroacupuncture (EA) at "Zusanli" (ST36) on improving cardiac function in mice with chronic heart failure (CHF), so as to explore the mechanism of its regulation on the autonomic nervous system.

Methods: Eighteen C57BL/6J mice were randomly divided into sham-surgery, model, and EA groups, with 6 mice in each group. The model of myocardial ischemia followed by CHF was induced by ligation of the anterior descending branch of the left coronary artery.

Identification of potential immune-related genes and infiltrations in temporomandibular joint osteoarthritis.

Objective: The aim of this study was to investigate the potential inflammatory cytokines and chemokines markers for temporomandibular joint osteoarthritis (TMJOA) diagnosis using a bioinformatics analysis.

Methods: The differentially expressed genes of mRNA (DEGs) and transcripts of lncRNA (DETs) were identified between TMJOA samples and normal controls curated from GSE205389 by the "DESeq. 2" R package.

A rechargeable coating with temporal-sequence antibacterial activity and soft tissue sealing.

Transcutaneous implants that penetrate through skin or mucosa are susceptible to bacteria invasion and lack proper soft tissue sealing. Traditional antibacterial strategies primarily focus on bacterial eradication, but excessive exposure to bactericidal agents can induce noticeable tissue damage. Herein, a rechargeable model (HPI-Ti) was constructed using perylene polyimide, an aqueous battery material, achieving temporal-sequence regulation of bacterial killing and soft tissue sealing.

Exploring Electron Transfer Mechanism in Synergistic Interactional Reduced Polyoxometalate-Based Cu(I)-Organic Framework for Photocatalytic Removal of U(VI).

Photocatalytic reduction of U(VI) is a promising method for removing uranium containing pollutants. However, using polyoxometalate-based metal-organic frameworks (POMOFs) for photoreduction of U(VI) is rare, and the relevant charge transfer pathway is also not yet clear. In this article, we demonstrate a highly efficient strategy and revealed a clearly electron transfer pathway for the photoreduction of U(VI) with 99% removal efficiency by using a novel POMOF, [Cu(4,4'-bipy)]·{AsMoMoVO(VO)[VO(HO)]}·2HO (), as catalyst.

Effective oxygen activation on polyoxometalate-based hybrids for epoxidation of alkenes.

Two polyoxometalate-based hybrids, [M(btap)(HO)(HPWO)]·HO (M-PW, M = Co/Mn, btap = 3,5-bis(1',2',4'-triazol-1'-yl)pyridine) were synthesized. Co-PW exhibited higher activity and selectivity towards olefin epoxidation than Mn-PW due to the synergistic effect between Co and PW, in which the Co centers activate O to ˙O and further binding of free H from PW affords the active peroxyacid.

The effect of part-list cuing on associative recognition.

The modulation of part-list cuing on item memory has been well-documented, whereas its impact on associative memory remains largely unknown. The present study explored the effect of part-list cuing on associative recognition and, more specifically, whether this forgetting effect caused by part-list cuing is more sensitive to recollection or familiarity in recognition memory. Experiments 1a and 1b combined the intact/rearranged/new judgement task of associative recognition with the classical part-list cuing paradigm, and the result showed that part-list cuing impaired the recognition accuracy of "intact" and "rearranged" face-scene pairs.

Clinicians' knowledge and understanding regarding multidisciplinary treatment implementation: a study in municipal public class III grade A hospitals in Southwest China.

Background: Previous studies have highlighted several problems in the implementation of multidisciplinary treatment (MDT) from a managerial perspective. However, no study has addressed these issues from clinicians' perspective. Therefore, this study aimed to identify and address the existing problems in MDT by investigating what clinicians know and think about the implementation of MDT.

Moxibustion ameliorated age-related alterations in neurological behavior and gut microbiota in mice.

Objective: To observe the anti-aging effects of moxibustion on age-related alterations in middle-aged mice.

Methods: Thirty, 9-month-old, male ICR mice were randomly divided into the moxibustion and control groups (N = 15). Mice in the moxibustion group were given mild moxibustion at the Guanyuan acupoint for 20 minutes every other day.

An injectable hydrogel combining medicine and matrix with anti-inflammatory and pro-angiogenic properties for potential treatment of myocardial infarction.

One of the main illnesses that put people's health in jeopardy is myocardial infarction (MI). After MI, damaged or dead cells set off an initial inflammatory response that thins the ventricle wall and degrades the extracellular matrix. At the same time, the ischemia and hypoxic conditions resulting from MI lead to significant capillary obstruction and rupture, impairing cardiac function and reducing blood flow to the heart.

Construction of ZnO/PCL Antibacterial Coating Potentially for Dental Unit Waterlines.

The formation of bacterial biofilms and the contamination of treatment water within dental unit waterlines can lead to a risk of secondary bacterial infections in immunocompromised patients. Although chemical disinfectants can reduce the contamination of treatment water, they can also cause corrosion damage to dental unit waterlines. Considering the antibacterial effect of ZnO, a ZnO-containing coating was prepared on the surface of polyurethane waterlines using polycaprolactone (PCL) with a good film-forming capacity.

Vertical variation of atmospheric particulate matter under different pollution levels in the suburbs of Tianjin based on unmanned aerial vehicle.

An unmanned aerial vehicle equipped with an isokinetic sampling device and a portable aerosol particle size spectrometer was used to detect atmospheric particles at different altitudes in the suburbs of Tianjin. In January 2017, four flight tests under different air conditions were conducted, and the Severe polluted and Excellent levels were classified according to the air quality index of the State-controlled site. Changes in mass concentration with altitude, and the vertical distribution of mass concentration and number concentration spectrum were analyzed.

A superlattice composite of Zn-Fe layered double hydroxide and graphene oxide for antitumor application.

A superlattice composite of Zn-Fe layered double hydroxide and graphene oxide was fabricated on the titanium surface and showed lamellar morphology. It was found for the first time that this superlattice composite could inhibit cell adhesion and proliferation, and cause cell death of the cholangiocarcinoma cell line RBE cells and show tumor inhibition effect .

Revisiting the multi-mechanism hypothesis of part-list cuing: the role of list-length and item presentation time.

When defining the associative encoding, the multi-mechanism hypothesis of part-list cuing does not heed the effect of list length and item presentation time. Through four experiments, this study first proved that short list length and long item presentation time were the boundary conditions of the part-list cuing effects (Experiment 1). Then, it was further found that under a shorter list length, no matter whether the study context was accessed or not, both the detrimental and beneficial effects of part-list cuing were absent (Experiment 2).

Occurrence, Molecular Characterization, and Antibiotic Resistance of in Goat Milk-Based Infant Formula from Shaanxi Province, China.

This study aimed to investigate the prevalence of in goat milk-based infant formula (GIF) collected from Shaanxi Province, China, and reveal the molecular characterization and antibiotic resistance profile of these isolates. A total of 750 GIF samples were collected from the retail markets in 5 cities in Shaanxi Province from February 2019 to February 2021. Molecular characterization was investigated using multilocus sequence typing and O-antigen serotyping.

Antibacterial Effect of Buds' Crude Extract Against Typhimurium and Potential Application in Cooked Chicken.

The objective of this study was to clarify the antibacterial activity and mechanism of buds' crude extract (CBCE) against Typhimurium, and explore the potential application in cooked chicken. The zone of inhibition (ZI), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were used to assess the antibacterial activity of CBCE against Typhimurium. The antibacterial mechanism was elucidated by revealing the changes in intracellular adenosine 5'-triphosphate (ATP) concentration, membrane potential, content of biomacromolecule, and cell morphology.

Antibacterial Mode of Male Flower Extract Against and Its Application as a Natural Preservative in Cooked Beef.

The research was conducted to elucidate the antibacterial performance and mode of action of male flower extract (EUMFE) against and its application as a natural preservative in cooked beef. The antibacterial activity was evaluated by determining the diameter of inhibition zone (DIZ), minimum inhibitory concentration (MIC), and minimum bactericide concentration (MBC). The changes in membrane potential, contents of bacterial DNA and protein, integrity and permeability of the cell membrane, and cell morphology were analyzed to reveal the possible mode of action.

The part-list cuing effect in working memory: The influence of task presentation mode.

The modulation of part-list cues on long-term memory has been well-documented, whereas its impact on working memory remains largely unknown. The current study recruited a working memory part-list cuing paradigm to investigate how re-exposing part-list items affected item representation in working memory, and more specifically, whether the cuing effect was modulated by the task presentation mode. Our results showed that when the part-list re-exposure and no-part-list re-exposure trials were presented in separate blocks, using the re-exposed items as retrieval cues (part-list cue condition) significantly impaired recognition speed, accuracy and elevated judgement criteria (Experiment 1a), whereas merely relearning the re-exposed items (part-list relearning condition) has no such effect (Experiment 1b).

[Emission Characteristics and Atmospheric Chemical Reactivity of Volatile Organic Compounds(VOCs) in Automobile Repair Industry].

Volatile organic compounds (VOCs) emitted by the automobile repair industry are an important source of ozone precursors. However, the current reduction policy generally focuses on the emissions of VOCs, without considering their chemical reactivity. Based on an investigation of the development status of China's automobile repair industry, this study analyzes VOCs emission nodes in different sections of automobile repair enterprises.

Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics.

Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization.

Antibacterial Activity of Crude Extract Against and Its Application as a Natural Disinfectant.

is an opportunistic food-borne pathogen that endangers the health of neonates and infants. This study aims to elucidate the antibacterial activity and mechanism of crude extract (CBCE) against and its application as a natural disinfectant. The antibacterial activity was evaluated by the determination of the diameter of inhibition zone (DIZ), minimum inhibitory concentration (MIC), and minimum bactericide concentration (MBC).

Strontium ions protect hearts against myocardial ischemia/reperfusion injury.

Timely restoration of blood supply following myocardial infarction is critical to save the infarcted myocardium, while reperfusion would cause additional damage. Strontium ions have been shown to promote angiogenesis, but it is unknown whether they can save the damaged myocardium. We report that myocardial ischemia/reperfusion (I/R)-induced functional deterioration and scar formation were notably attenuated by injection of strontium ion-containing composite hydrogels into murine infarcted myocardium at 20 minutes of reperfusion following 60 minutes of ischemia.

Part-List Cues Hinder Familiarity but Not Recollection in Item Recognition: Behavioral and Event-Related Potential Evidence.

Participants' memory performance is normally poorer when a subset of previously learned items is provided as retrieval cues than none of the retrieval cues is provided. This phenomenon is called the part-list cuing effect, which has been discovered in numerous behavioral studies. However, there is currently no relevant behavioral or event-related potential (ERP) research to investigate whether the forgetting effect caused by part-list cues is more sensitive to recollection or to familiarity.