Publications by authors named "Min Xie"

Article Synopsis
  • The maintenance of endoplasmic reticulum (ER) balance is essential for spinal cord injury (SCI) recovery, with protein disulfide isomerase A6 (PDIA6) and spastin identified as key regulators.
  • PDIA6 interacts with spastin, which is crucial for organizing the microtubule network around the ER, and both proteins work together to enhance neuron repair after injury.
  • Research demonstrated that PDIA6 promotes neuron recovery, while reducing its levels inhibits spastin's microtubule activity, suggesting that targeting these proteins may provide new strategies for improving SCI repair.
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Objective: This study was aimed to investigate the characteristics of the amplitude of low-frequency fluctuation (ALFF) at specific frequencies in severe obstructive sleep apnea (OSA) patients. A comparison was made between pre-CPAP treatment and one night after continuous positive airway pressure (CPAP) treatment.

Methods: 30 severe OSA patients and 19 healthy controls (HC) were recruited.

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  • Colorectal cancer is a highly aggressive form of cancer, prompting researchers to investigate how it develops and progresses.* -
  • Cellular senescence is a natural process in which cells stop dividing, and it plays a significant role in the initiation and advancement of cancers, including colorectal cancer.* -
  • The authors highlight recent studies that suggest senescence could affect both the development and progression of colorectal cancer.*
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The Wildsoydb DataHub is an integrated interface for biologists and breeders to access soybean genomic resources easily, allowing them to fully utilize the results of genomic research.

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Prebiotic molecules have often been identified in the interstellar medium and meteorite samples. However, we still have only a fragmentary knowledge of the mechanism of the evolutionary process of these prebiotic molecules. With the aid of state-of-the-art vacuum ultraviolet (VUV)-infrared (IR) spectroscopy and calculations, we reveal a new pathway leading to the formation of the biorelevant molecules carrying amine groups or peptide bonds via the single-photon ionization induced Michael/cyclization reaction of acrylonitrile (AN)-alcohol heterodimer complexes in the gas phase.

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Given the abundance of heme proteins (cytochromes) in the mitochondrion, it is evident that a meticulously orchestrated iron metabolism is essential for cardiac health. Here, we examined the functional significance of myocardial ferritin heavy chain (FtH) in a model of acute myocardial infarction. We report that FtH deletion did not alter either the mitochondrial regulatory and surveillance pathways (fission and fusion) or mitochondrial bioenergetics in response to injury.

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  • Oxaliplatin (OXA) is a chemotherapy drug that helps treat some cancers but can cause painful nerve problems for patients.
  • In a study with rats, researchers found that OXA caused pain and inflammation in the spine, making the rats uncomfortable.
  • They tested a substance called resveratrol (Res), which helped reduce the pain by lowering inflammation and protecting the nerves from OXA’s harmful effects.
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Objective: Through a retrospective large sample analysis of copy number variants in single center, we explored the technical standards for the interpretation and reporting of constitutional copy-number variants (CNVs) jointly proposed by the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen) in 2019, analyzing its impact on CNVs ratings and the improvement in the consistency of the classification of CNVs in clinical laboratories.

Methods: 236 CNVs that assessed as pathogenic, uncertain significant (including likely pathogenic, uncertain and likely benign) by the 2011 ACMG guidelines between August 2018 and December 2019 in our center were re-analyzed. Four working group members of the center reclassified and evaluated 235 CNVs according to 2019 ACMG guidelines.

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Background: Asthma patients potentially have impaired adaptive immunity to virus infection. The levels of SARS-CoV-2-specific adaptive immunity between COVID-19 survivors with and without asthma are presently unclear.

Methods: COVID-19 survivors (patients with asthma n=11, with allergies n=8, and COVID-19 only n=17) and non-COVID-19 individuals (asthmatic patients n=10 and healthy controls n=9) were included.

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Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the genetic structure of BD subtypes. We aimed to investigate the genetic overlap and distinction of bipolar type I (BD I) & type II (BD II) by conducting integrative post-GWAS analyses. We utilized single nucleotide polymorphism (SNP)-level approaches to uncover correlated and distinct genetic loci.

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  • Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by improper immune responses leading to multi-organ damage, largely due to dysfunctional T cells and excessive autoantibodies from B cells.
  • Recent studies suggest that human umbilical cord mesenchymal stem cells (hUCMSCs) and their extracellular vesicles (hUCMSC-EVs) may help regulate these immune responses in SLE, though the role of MSC-EVs is not fully understood.
  • In experiments using a mouse model of SLE, both hUCMSCs and hUCMSC-EVs were found to inhibit certain T cell activities while promoting others, indicating that hUCMSC-EVs could serve as potential therapeutic agents in
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Objective: The prognosis of children with refractory acute myeloid leukemia (AML) is poor. Complete remission (CR) is not always achieved with current salvage chemotherapy regimens before transplantation, and some patients have no chance of transplantation. Here, we aimed to describe a new regimen of conventional chemotherapy drugs (homoharringtonine, cladribine , and aclarubicin (HCA)) for refractory AML and its mechanism in vitro.

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Purpose: The molecular links between metabolism and inflammation that drive different inflammatory phenotypes in asthma are poorly understood. We aimed to identify the metabolic signatures and underlying molecular pathways of different inflammatory asthma phenotypes.

Methods: In the discovery set (n = 119), untargeted ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was applied to characterize the induced sputum metabolic profiles of asthmatic patients with different inflammatory phenotypes using orthogonal partial least-squares discriminant analysis (OPLS-DA), and pathway topology enrichment analysis.

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Traditional treatments for leukemia fail to address stem cell drug resistance characterized by epigenetic mediators such as histone lysine-specific demethylase 4 (KDM4). The KDM4 family, which acts as epigenetic regulators inducing histone demethylation during the development and progression of leukemia, lacks specific molecular inhibitors. The KDM4 inhibitor, SD49-7, was synthesized and purified based on acyl hydrazone Schiff base.

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Article Synopsis
  • A prospective multi-institutional trial with 419 pediatric patients under 16 diagnosed with aggressive B-cell non-Hodgkin lymphoma/leukemia explored the safety and efficacy of adding rituximab to intensive chemotherapy.
  • The study found that the overall 4-year event-free survival (EFS) rate was 88.3%, with significantly better outcomes across different treatment groups, particularly for those receiving rituximab.
  • Some toxicities associated with rituximab included high rates of severe infections and blood cell issues, but the treatment showed to be feasible in less-resourced settings and improved EFS compared to historical data.
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Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces infarct size and enhances cardiomyocyte autophagy and PGC1α-mediated mitochondrial biogenesis when administered at the time of reperfusion. Furthermore, a specific autophagy-inducing peptide, Tat-Beclin 1 (TB), reduces infarct size when administered at the time of reperfusion.

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In recent years, the increased frequency of natural hazards has led to more disruptions in power grids, potentially causing severe infrastructural damages and cascading failures. Therefore, it is important that the power system resilience be improved by implementing new technology and utilizing optimization methods. This paper proposes a data-driven spatial distributionally robust optimization (DS-DRO) model to provide an optimal plan to install and dispatch distributed energy resources (DERs) against the uncertain impact of natural hazards such as typhoons.

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Objective: Serine hydroxymethyltransferase 2 (SHMT2) is the first rate-limiting enzyme for serine/glycine biosynthesis and one carbon metabolism. Here, we explore the underlying mechanism of how SHMT2 functions in renal cell carcinoma (RCC) initiation.

Methods: In this study, SHMT2 expression was assessed in RCC tissues.

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Amyloidosis is characterized by systemic or local deposition of amyloid fibrils outside organs and tissues. Amyloidosis is rarely seen on cornea. A 30-year-old woman patient had had trichiasis in both eyes for 8 years.

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Asthma is a multifactorial disorder characterized by the airway chronic inflammation, hyper-responsiveness (AHR), remodeling, and reversible obstruction. Although asthma is known as a heterogeneous group of diseases with various clinical manifestations, recent studies suggest that more than half of the clinical cases are ''T helper type 2 (Th2)-high'' type, whose pathogenesis is driven by Th2 responses to an inhaled allergen from the environmental exposures. The intensity and duration of inflammatory responses to inhaled allergens largely depend on the balance between effector and regulatory cells, but many questions regarding the mechanisms by which the relative magnitudes of these opposing forces are remained unanswered.

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Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have distinct tissue-specific characteristics compared to their counterparts in peripheral blood and lymphoid organs. Based on their location and the pregnancy status of the host, uNK cells are classified as endometrial NK (eNK) cells or decidua NK (dNK) cells.

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Early in the pandemic of coronavirus disease 2019 (COVID-19), face masks were used extensively by the general public in several Asian countries. The lower transmission rate of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Asian countries compared with Western countries suggested that the wider community use of face masks has the potential to decrease transmission of SARS-CoV-2. A risk assessment model named Susceptible, Exposed, Infectious, Recovered (SEIR) model is used to quantitatively evaluate the potential impact of community face masks on SARS-CoV-2 reproduction number (R ) and peak number of infectious persons.

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Bone is the preferential site of metastasis for breast cancer. Invasion of cancer cells induces the destruction of bone tissue and damnification of peripheral nerves and consequently induced central sensitization which contributes to severe pain. Herein, cancer induced bone pain (CIBP) rats exhibited destruction of tibia, mechanical allodynia and spinal inflammation.

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Potential relationships among heavy air pollution, weather conditions, and meteorological effects are unclear and require further investigation, especially for areas with complex terrains, such as the Sichuan Basin (SCB), one of the most polluted regions in China. In this study, air pollution in the SCB was examined and 18 regional persistent heavy pollution events (RPHEs) were identified for the winters of 2014-2018. The average persistent period of the RPHEs was 8.

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