Ethanol Extracts of Improve Benign Prostatic Hyperplasia by Inhibiting Prostate Cell Proliferation through Modulating 5 Alpha-Reductase/Androgen Receptor Axis-Mediated Signaling.

Purpose: The aim of this study was to investigate the efficacy of ethanol extracts of (ECA) against benign prostatic hyperplasia (BPH) and .

Materials And Methods: The prostate stromal cells (WPMY-1) and epithelial cells (RWPE-1) were used to examine the action mechanism of ECA in BPH . ECA efficacy was evaluated using a testosterone propionate (TP)-induced BPH rat model.

Chemopreventive Activity of Ellagitannins from (Pax) Komarov Leaves on Prostate Cancer Cells.

Several studies have shown that compounds from (Pax) Komarov leaves (APL) display potent anti-oxidative, anti-inflammatory, and anti-proliferative activities. Prostate cancer (PCa) is the most common cancer among older men, and DNA methylation is associated with PCa progression. This study aimed to investigate the chemopreventive activities of the compounds which were isolated from APL on prostate cancer cells and elucidate the mechanisms of these compounds in relation to DNA methylation.

Antiacne and Anti-Inflammatory Effects of Phenolic Compounds from Carruth. Leaves.

plants are widely distributed in Korea and have been used for their antiallergic and anti-inflammatory properties to treat dermatitis. The phenolic compounds of Carruth (QA) are estimated to have antioxidant and anti-inflammatory activities, based on the results of previous studies with , , Blame., and Thunb.

Inhibition of the NLRP3 Inflammasome by a Quercus Serrata Extract and Isolation of the Component Compounds for the Treatment of Arthritis.

belongs to the Fagaceae family. There are 600 known species of worldwide. is distributed nationally in Korea, Japan, and China and grows to a height of 10-15 m.

Permutation entropy analysis of the output of a laser diode under stimulated Brillouin scattering optical feedback.

The chaotic output emitted by a diode laser with optical feedback has fascinated the community for decades. The external cavity delay time imparts a weak level of periodicity to the laser output (the so-called "time delay signature", TDS) that is a drawback for applications that require random optical signals. A lot of efforts have focused in suppressing the TDS either by post-processing the signal or by using alternative ways to generate random optical signals.

Inhibitory Activities of Dimeric Ellagitannins Isolated from on Benign Prostatic Hypertrophy.

Benign prostatic hypertrophy (BPH) is an intractable chronic inflammatory disease. We studied the efficacy of two ellagitannins, namely camptothin B () and cornusiin A () that were isolated from (CA) for the treatment of BPH, which is a common health issue in older men. The ellagitannins ( and ) were evaluated on its inhibitory activities of the enzyme 5α-reductase and tumor necrosis factor (TNF)-α, its interleukin (IL)-1β, IL-6, and IL-8 production, and its anti-proliferation and apoptosis induction in prostate cells that show hypertrophy (RWPE-1 cell).

Compounds Exhibiting Anti-Proliferative, Apoptosis-Inducing, and Demethylating Effects on Prostate Cancer Cells.

(AS) is distributed in Korea, Japan, China, and Russia and has reported anti-oxidant, anti-inflammatory, and reducing activities on atopic dermatitis-like skin lesions, along with other beneficial health properties. In the present study, we tried to prove the cancer-preventive activity against prostate cancer. The extracted and isolated compounds, oregonin (), hirsutenone (), and hirsutanonol (), which were isolated from AS, were tested for anti-proliferative activity.

Anti-Inflammatory Effects of Fermented Bark of and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells.

The fermentation was carried out on the bark of (AS). species have been used in traditional medicine as tonics, sedatives, and antispasmodics. An activity-guided isolation of the fermented bark of (FAS) yielded several phytochemicals: acanthoside D (), acanthoside B (), daucosterol (), protocatechuic acid (), chlorogenic acid methyl ester (), ciwujiatone (), syringaresinol (), farnesol (), 3,4-dicaffeoylquinic acid (), and falcarindiol ().

Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of by Anti-Inflammatory Activity and 5α-Reductase Inhibition.

(QM)-a member of the Fagaceae family-has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA).

Anti-Inflammatory Effects of Extract on In Vitro and In Vivo Models.

extracts (ASex) have long been used in Oriental medicine to treat various conditions. To provide a scientific basis for this application and the underlying mechanism, we investigated the anti-inflammatory effects of ASex in vitro and in vivo. The in vitro model was established using human dermal fibroblasts (HDFs) treated with inflammatory stimulants (lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma).

Anti-acne vulgaris effect including skin barrier improvement and 5α-reductase inhibition by tellimagrandin I from Carpinus tschonoskii.

Background: Carpinus tschonoskii (CT) has been previously studied for various activities in the improvement of skin diseases. In the present study, we examined the in vitro anti-acne vulgaris (AV) effect of CT leaves (CTL) and tellimagrandin I (TI), one of the main ellagitannins from CT, including skin barrier improvement and 5α-reductase inhibitory activity.

Methods: To test the anti-AV activities of CTL and TI, firstly, anti-oxidative and anti-inflammatory activities including DPPH radical scavenging activity, nitric oxide (NO) inhibitory activity, and cytokines [interleukin (IL)-6 and IL-8] were tested.

Anti-Inflammatory Effects of Phenolic Compounds Isolated from Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells.

Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis.

Extracts Suppress the Expression of Inflammatory Cytokines Induced by Lipopolysaccharides, Tumor Necrosis Factor-α, and Interferon-γ in Human Dermal Fibroblasts.

The effects of (AS) extracts on cytokine expression induced by inflammatory stimulants were examined in human dermal fibroblasts (HDFs) and RAW264.7 cells. The anti-oxidative effect and effect on cell viability of AS extracts were evaluated, and four extracts with the highest anti-oxidative effects were selected.

Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of .

(AS) is geographically distributed in Korea, Japan, Northeast China, and Russia. Various anti-oxidant, anti-inflammation, anti-atopic dermatitis and anti-cancer biological effects of AS have been reported. Enzymatic hydrolysis decomposes the sugar bond attached to glycoside into aglycone which, generally, has a superior biological activity, compared to glycoside.

Anti-Obesity Activities of Chikusetsusaponin IVa and L. Seeds.

Obesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight.

Anti-skin ageing effects of phenolic compounds from .

(CT) is distributed through in southern regions of South Korea. Six known compounds, including three ellagitannins, one gallotannin, and two flavonoids were isolated from CT. In conclusion, the tannins, especially ellagitannins, and CT extract showed potent anti-oxidative, anti-inflammatory and anti-skin ageing activities.

Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica.

Phytochemical isolation of fermented (FAS) which was produced by using subsp. , exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation of Th₁/Th₂ cytokines and IgE in blood) of FAS and the barks of extract (AS) and the two diarylheptanoids, hirsutenone () and muricarpon B (), which are major components of FAS, were measured in vitro and in vivo.

Multiwavelength generation from multi-nonlinear optical process in a 2D PPLT.

We have demonstrated multi-wavelength generation in a nonlinear photonic crystals of lithium tantalate. The optical parametric generation leads to second harmonic generation, sum-frequency generation and other frequency conversion in a cascade process. These conversions are assisted by all the optical nonlinear process involving χ and achieved by satisfying the quasi-phase matching conditions.

Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis.

Fermentation of (AS) stems using subsp. was conducted and three compounds isolated from the species were identified for the first time, 7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)-heptan-3-one, 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptan-3-one and 4-(3,4-dihydroxyphenyl)-butan-2-one, along with 14 known compounds. The anti-oxidative and anti-inflammatory abilities of AS and fermented AS (FAS) as well as the isolated phenolic compounds from FAS were investigated.

Anti-Inflammatory and Anti-Urolithiasis Effects of Polyphenolic Compounds from Quercus gilva Blume.

Bume (QGB, family Fagaceae) is a tall evergreen oak species tree that grows in warm temperate regions in Korea, Japan, China and Taiwan. plants have long been the basis of traditional medicines. Their clinical benefits according to traditional medicine include relief of urolithiasis, tremors and inflammation.

Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of .

Chromatographic isolation of the 80% MeOH extract of (AG) yielded seven galloyl derivatives: gallic acid (), ginnalin B (), acertannin (), maplexin D (), maplexin E (), quercetin-3--(2''-galloyl)--L-rhamnopyranoside (), and kaempferol-3--(2''-galloyl)--L-rhamnopyranoside (). This is the first study to report the isolation of compounds and from AG. Galloyl derivatives - exhibited potent radical scavenging activities, with and showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.

Efficient methods for isolating five phytochemicals from Gentiana macrophylla using high-performance countercurrent chromatography.

Efficient high-performance countercurrent chromatography methods were developed to isolate five typical compounds from the extracts of Gentiana macrophylla. n-Butanol-soluble extract of G. macrophylla contained three hydrophilic iridoids, loganic acid (1), swertiamarin (2) and gentiopicroside (3), and a chromene derivative, macrophylloside D (4) which were successfully isolated by flow rate gradient (1.

Demonstration of optical rogue waves using a laser diode emitting at 980 nm and a fiber Bragg grating.

Rogue waves are observed for the first time, to the best of our knowledge, in a 980 nm laser diode subject to filtered optical feedback via a fiber Bragg grating. By counting the number of rogue waves in a fixed time window, a rogue wave map is established experimentally as a function of both the optical feedback ratio and the laser current. The comparison with low frequency fluctuations (LFFs) reveals that the rogue waves observed in our system are, in fact, LFF jump-ups.

Inhibitory Activities of Phenolic Compounds Isolated from Adina rubella Leaves Against 5α-Reductase Associated with Benign Prostatic Hypertrophy.

Adina rubella Hance (AR), a plant native to Korea, has been used as traditional medicine for dysentery, eczema, intoxication, and external hemorrhages. Previous phytochemical studies of AR have reported several components, including terpenoids, phenolics, and alkaloids. The current study evaluated the anti-oxidative and anti-inflammatory activities and 5α-reductase inhibition of isolated compounds of AR leaves to find a potential therapeutic agent for benign prostatic hypertrophy (BPH).

High-resolution low-frequency fluctuation map of a multimode laser diode subject to filtered optical feedback via a fiber Bragg grating.

A highly detailed and extended map of low-frequency fluctuations is established for a high-power multi-mode 980 nm laser diode subject to filtered optical feedback from a fiber Bragg grating. The low-frequency fluctuations limits and substructures exhibit substantial differences with previous works.