Publications by authors named "Min W"
Chemerin, an adipocyte-secreted adipokine, can regulate bone resorption and bone formation and is a promising therapy for postmenopausal osteoporosis. However, the effect of endogenous chemerin on intraosseous vascular remodeling in postmenopausal osteoporosis remains unclear. In this study, we investigated the effect of chemerin on osteogenesis formation and intraosseous vascular remodeling in ovariectomized Rarres2 knockout (Rarres2) mice.
View Article and Find Full Text PDFCorrection for 'Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on HO-injured HT-22 cells' by Yunlong Jiang , , 2022, , 12021-12038, https://doi.org/10.1039/D2FO02131E.
View Article and Find Full Text PDFEsophageal cancer is a grave malignant condition. While radiotherapy, often in conjunction with chemotherapy, serves as a cornerstone in the management of locally advanced or metastatic cases, patient tolerance and treatment resistance frequently hinder its efficacy. Cell-in-cell structures, prevalent in various tumors, have been linked to prognosis.
View Article and Find Full Text PDFBackground: Medial meniscus posterior root tears (MMPRTs) significantly contribute to knee dysfunction, leading to abnormal biomechanics and accelerated cartilage degeneration. Arthroscopic transtibial pullout and all-inside repair are two commonly used techniques for treating MMPRTs, each with unique advantages and limitations.
Objective: To compare the clinical and functional outcomes of the transtibial pullout and all-inside repair techniques in the treatment of MMPRTs, with a focus on postoperative recovery, knee function, and complications.
MTDH-SND1 protein-protein interaction (PPI) plays an important role in the initiation and development of tumors, and it is a target for the treatment of breast cancer. In this study, we identified and synthesized a series of novel small-molecule inhibitors of MTDH-SND1 PPI. The representative compound showed potent activity against MTDH-SND1 PPI with an IC of 487 ± 99 nM and tight binding to the SND1-purified protein with a value of 279 ± 17 nM.
View Article and Find Full Text PDFPolymers with strong electron-withdrawing groups (e.g., cyano-containing polymers) are attractive for a wide range of applications due to their high dielectric constant and outstanding electrochemical stability.
View Article and Find Full Text PDFIntraperitoneal Treatment of Cambinol, a Synthetic SIRT1 and SIRT2 Inhibitory Compound, Exacerbates 544 Burden in the Spleens of Institute of Cancer Research Mice.
Microorganisms
December 2024
Our preliminary data using bone marrow-derived macrophages (BMDMs) collected from ICR mice treated with anti-sirtuin (anti-SIRT) 1 antibody showed that uptake was significantly attenuated. We then further investigated the effect of an inhibitor of SIRT1/2, cambinol, in the progression of . The in vitro results using RAW264.
View Article and Find Full Text PDFSpatial transcriptomics has significantly advanced the measurement of spatial gene expression in the field of biology. However, the high cost of ST limits its application in large-scale studies. Using deep learning to predict spatial gene expression from H&E-stained histology images offers a more cost-effective alternative, but existing methods fail to fully leverage the multimodal information provided by Spatial transcriptomics and pathology images.
View Article and Find Full Text PDFDiagnostic value of SAT-TB in stool and urine samples for intestinal and urinary tuberculosis.
Diagn Microbiol Infect Dis
December 2024
Background: The simultaneous amplification/testing for tuberculosis (SAT-TB) targets specific 16s rRNA for detecting Mycobacterium tuberculosis in real-time.
Objective: To evaluate SAT-TB's performance in detecting intestinal and urinary TB using stool and urine samples.
Methods: Stool (94) and urine samples (69) (From 2021 to 2022), were collected from pulmonary combined with suspected intestinal or urinary tuberculosis.
High prevalence of low bone mineral density in middle-aged adults in Shanghai: a cross-sectional study.
BMC Musculoskelet Disord
December 2024
Purpose: To assess bone mineral density (BMD) in middle-aged individuals in Shanghai, in order to improve awareness of osteopenia and osteoporosis screening.
Methods: The clinical data of 1107 permanent residents of Shanghai aged 40-60 years were collected using a random cluster sampling method. Osteoporosis questionnaire survey and BMD test were conducted.
Inhibiting the activity of immune checkpoint proteins to reignite the antitumor activity of immune cells has emerged as a pivotal strategy. PD-L1 and VISTA, as critical proteins governing immune regulation, are concurrently upregulated under conditions such as hypoxia. Through a rational drug design process, , a dual-target inhibitor for PD-L1 and VISTA is identified.
View Article and Find Full Text PDFThe rapid development of spatial transcriptomics (ST) technology has provided unprecedented opportunities to understand tissue relationships and functions within specific spatial contexts. Accurate identification of spatial domains is crucial for downstream spatial transcriptomics analysis. However, effectively combining gene expression data, histological images and spatial coordinate data to identify spatial domains remains a challenge.
View Article and Find Full Text PDFNaFe(PO)PO (NFPP) has been regarded as the promising cathode material for sodium-ion batteries (SIBs). However, the practical applications of NFPP are hindered by its high-volume changes, poor intrinsic electron conductivity and sluggish Na+ ions diffusion kinetics. Herein, a spray-drying and solid-state reaction method have been utilized to fabricate the spherical trace amount Mg/Cu co-doped NaFe(PO)PO (NFMCPP).
View Article and Find Full Text PDFRecent extensive studies on the genomic and molecular profiles of acute myeloid leukemia (AML) have expanded the treatment options, including, a range of compounds represented by fms-like tyrosine kinase 3 and isocitrate dehydrogenase 1/2 inhibitors. However, despite this progress, further treatments for AML are still required. Adenosine deaminase acting on RNA 1 (ADAR1) has been shown to play an important oncogenic role in many cancers, but its involvement in AML progression remains underexplored.
View Article and Find Full Text PDFBackground: Nursing leadership by head nurses is critical to enhancing nursing research activity and performance in hospitals but the impact mechanism is unclear.
Aim: To investigate the effect of nursing leadership of head nurses on research burnout, self-efficacy, and performance of highly-educated nurses in the hospital.
Methods: A cross-sectional survey was conducted and electronic questionnaires were distributed online.
This study aims to develop a reference material that enables precise management of dopant distribution in power semiconductors. We thoroughly investigate the structural and surface properties of 4H-silicon carbide (4H-SiC) single crystals implanted without annealing using aluminum (Al) and phosphorus (P) ions. Ion-implanted 4H-SiC was thoroughly evaluated using advanced techniques, including X-ray diffraction (XRD), field emission transmission electron microscopy (FE-TEM), atomic force microscopy (AFM), time of flight medium energy ion scattering (ToF-MEIS), and secondary ion mass spectrometry (SIMS).
View Article and Find Full Text PDFThe advent of spatially resolved transcriptomics (SRT) has provided critical insights into the spatial context of tissue microenvironments. Spatial clustering is a fundamental aspect of analyzing spatial transcriptomics data. However, spatial clustering methods often suffer from instability caused by the sparsity and high noise in the SRT data.
View Article and Find Full Text PDFSpatial transcriptomics (ST technology allows for the detection of cellular transcriptome information while preserving the spatial location of cells. This capability enables researchers to better understand the cellular heterogeneity, spatial organization, and functional interactions in complex biological systems. However, current technological methods are limited by low resolution, which reduces the accuracy of gene expression levels.
View Article and Find Full Text PDFThe advent of stimulated Raman scattering (SRS) microscopy has launched a rapidly growing field in chemical imaging with broad impact. Although the physical picture seems to be well understood from classical models, prediction of absolute SRS signals remains a challenge. Here, we present a quantum electrodynamics treatment of the newly introduced stimulated Raman cross section.
View Article and Find Full Text PDFRice small protein OsS1Fa1 participates in stress responses as an inner nuclear membrane protein.
Plant Signal Behav
December 2024
The rice small protein OsS1Fa1, a homolog of spinach S1Fa, plays a significant role in drought tolerance, attributed to its transmembrane domain. In this study, we aim to further elucidate the potential roles of OsS1Fa1 in cold and biotic stresses as an inner nuclear membrane protein. Fluorescence analysis confirmed the localization of OsS1Fa1 to the inner nuclear membrane.
View Article and Find Full Text PDFAberrant autophagic flux and epigenetic mechanisms are involved in the development of neurodegenerative diseases. However, limited studies have been conducted on the relationship between the histone acetylation-particularly sirtuin 2 (SIRT2)-and autophagy in cognitive deficiency. We investigated the effects of a walnut-derived peptide (WNP-8) on SIRT2, synaptic plasticity, and autophagy and the involvement of SIRT2 in learning and memory.
View Article and Find Full Text PDFThis manuscript presents ABSAS-CS-GSA, an improved iteration of the beetle antennae search (BAS) algorithm, tailored to address the shortcoming of the BAS with low convergence accuracy and easily falling into local optima. The improvements are structured into three principal components: first, dynamic step-size adjustment predicated on initial population to bolster solution accuracy and expedite convergence; second, position update mechanism integrating golden sine algorithm to diversify search patterns and expedite convergence; and third, population disturbance based on vertical and horizontal cross strategy to avoid falling into local optima. Experimental results on 12 benchmark functions demonstrate ABSAS-CS-GSA's superiority over the standard BAS and its four variants, as well as over two classic swarm intelligence algorithms.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates key RNA silencing components (AGO, DCL, and RDR) in centipedegrass, a turfgrass species, highlighting their roles in small RNA generation and stress responses, which are crucial for plant development.
- - Researchers identified 20 AGO, 6 DCL, and 10 RDR genes through genome-wide analysis, examining their characteristics, evolutionary relationships, and expression patterns under various stress conditions (cold, salt, drought).
- - Findings show that most genes are upregulated during stress, suggesting specialized functions, and the comprehensive analysis lays the groundwork for future studies on RNA silencing and stress responses in turfgrass.
Molecular imaging with analyte-responsive probes offers a powerful chemical approach to studying biological processes. Many reagents for bioimaging employ a fluorescence readout, but the relatively broad emission bands of this modality and the need to alter the chemical structure of the fluorophore for different signal colors can potentially limit multiplex imaging. Here, we report a generalizable approach to multiplex analyte imaging by leveraging the comparably narrow spectral signatures of stimulated Raman scattering (SRS) in activity-based sensing (ABS) mode.
View Article and Find Full Text PDFWalnut peptides exhibit promising neuroprotective effects; however, they must be absorbed in their intact form through the gastrointestinal tract into the bloodstream and brain. In this study, the effects of the walnut peptide TWLPLPR (TW-7) were evaluated in mice, including its absorption and distribution ability to cross the blood-brain barrier, and inhibitory effects on hyperactivity of primary hippocampal neurons. TW-7 was stable in plasma, and the peptide retention rate was 88.
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