Preparation of porous carbon derived from a lignin-based polymer through ZnCl activation for effective capture of iodine.

Lignin-based porous carbon, a derivative of lignin, is acknowledged for its cost-effectiveness, stability, and environmental sustainability. It exhibits significant adsorption capacity for the removal of heavy metals and in wastewater treatment, rendering it a highly esteemed adsorbent material. However, the potential of lignin-derived porous carbon for the capture of iodine in environmental contexts has yet to be thoroughly investigated.

Real-world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury.

Objective: The short-term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear.

Methods: We used the MIMIC database to compare the efficacy of liberal (10 g/dL) versus conservative (7 g/dL) transfusion strategy in TBI patients. The outcomes were neurological progression (decrease of Glasgow coma scale (GCS) of at least 2 points) and death within 28 days of ICU admission.

[Establishment of a nomogram prediction model for 28-day mortality of septic shock patients based on routine laboratory data mining].

Objective: To construct a nomogram prediction model for 28-day mortality in septic shock patients based on routine laboratory data mining and verify its predictive value.

Methods: The clinical data of patients with septic shock admitted to Anhui Medical University Affiliated Fuyang Hospital from January 2018 to November 2023 were retrospectively analyzed. The patients were randomly divided into training set and validation set according to the ratio of 8 : 2.

Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management.

: Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), a critical and often fatal condition marked by acute inflammation and elevated pulmonary vascular permeability. Despite this, there are currently no FDA-approved therapeutics specifically targeting ferroptosis for ARDS management. : A screening of 259 FDA-approved drugs was conducted to identify an effective ferroptosis inhibitor in pulmonary epithelial and endothelial cells.

Novel str. 1D1416 for Citrus Transformation.

Citrus is one of the world's most important and widely produced fruit crops, with over a 100 million metric tons harvested from nearly 10 million hectares in 2023. Challenges in crop maintenance, production, and fruit quality necessitate developing new traits through Agrobacterium-mediated genetic transformation. While a few strains (EHA105, GV3101, LBA4404) are known to transform citrus, many wild strains remain untested.

Group empathy for pain is stronger than individual empathy for pain in the auditory modality.

Humans live in collective groups and are highly sensitive to perceived emotions of a group, including the pain of a group. However, previous research on empathy for pain mainly focused on the suffering of a single individual ("individual empathy for pain"), with limited understanding of empathy for pain to a group ("group empathy for pain"). Thus, the present study aimed to investigate the cognitive neural mechanisms of group empathy for pain in the auditory modality.

Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database.

Local Release of Copper Manganese Oxide Using HA Microneedle for Improving the Efficacy of Drug-Resistant Wound Inflammation.

The production of bacterial toxins and excessive accumulation of reactive oxygen species (ROS) can induce localized oxidative stress, triggering an exaggerated immune response that impedes wound healing and culminates in chronic wounds. To address this issue, a microneedle (MN) system loaded with copper-manganese oxide (CMO) is developed to modulate the hyperimmune response in wounds. CMO@MN exhibits excellent antimicrobial and anti-inflammatory properties by effectively killing bacteria, scavenging ROS, and modulating macrophage polarization through their multiple enzymatic activities and photothermal properties.

Development and application of a nitrogen oxides analyzer based on the cavity attenuated phase shift technique.

Nitrogen oxides (NO) are crucial in tropospheric photochemical ozone (O) production and oxidation capacity. Currently, the widely used NO measurement technique is chemiluminescence (CL) (CL-NO), which tends to overestimate NO due to atmospheric oxidation products of NO (i.e.

A novel prognosis evaluation indicator of patients with sepsis created by integrating six microfluidic-based neutrophil chemotactic migration parameters.

Impaired neutrophil migration in sepsis is associated with a poor prognosis. The potential of utilizing neutrophil chemotaxis to assess immune function, disease severity, and patient prognosis in sepsis remains underexplored. This study employed an innovative approach by integrating a multi-tip pipette with a Six-Unit microfluidic chip (SU-chip) to establish gradients in six microchannels, thereby analyzing neutrophil chemotaxis in sepsis patients.

Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo.

Parkinson's disease (PD) poses a formidable challenge in neurology, marked by progressive neuronal loss in the substantia nigra. Despite extensive investigations, understanding PD's pathophysiology remains elusive, with no effective therapeutic intervention identified to alter its course. Oxyphylla A (OPA), a natural compound extracted from Alpinia oxyphylla, exhibits promise in experimental models of various neurodegenerative disorders (ND), notably through novel mechanisms like α-synuclein degradation.

Co-delivery of camptothecin and MiR-145 by lipid nanoparticles for MRI-visible targeted therapy of hepatocellular carcinoma.

Background: Camptothecin (CPT) is one of the frequently used small chemotherapy drugs for treating hepatocellular carcinoma (HCC), but its clinical application is limited due to severe toxicities and acquired resistance. Combined chemo-gene therapy has been reported to be an effective strategy for counteracting drug resistance while sensitizing cancer cells to cytotoxic agents. Thus, we hypothesized that combining CPT with miR-145 could synergistically suppress tumor proliferation and enhance anti-tumor activity.

An early sepsis prediction model utilizing machine learning and unbalanced data processing in a clinical context.

Background: Early and accurate diagnoses of sepsis patients are essential to reduce the mortality. However, the sepsis is still diagnosed in a traditional way in China despite the increasing number of related studies, which may to some extent lead to delays in the treatment.

Methods: The study included 2,385 patients, including 364 with sepsis, collected from the First Affiliated Hospital of Anhui Medical University and partner hospitals from April to July 2022.

Diphenylacetylene-Incorporating Octaphyrin: A Rigid Macrocycle with Readily Separable Conformational Isomers.

An expanded carbaporphyrinoid analogue, octaphyrin(2,1,1,1,2,1,1,1), containing two rigid diphenylacetylene moieties is reported. In contrast to traditional pyrrolic macrocycles where flexible conformers coexist in dynamic equilibrium, this macrocycle exists as two separable, conformationally stable stereoisomers, denoted as 1A and 1B. The conformational effect of both conformers, as well as their protonated forms, were thoroughly studied using NMR spectroscopy, UV/Vis, and single crystal X-ray diffraction analyses.

Intercomparison of measured and modelled photochemical ozone production rates: Suggestion of chemistry hypothesis regarding unmeasured VOCs.

Ozone (O) pollution is a severe environmental problem in China. The incomplete understanding of atmospheric photochemical reaction mechanisms prevents us from accurately understanding the chemistry of O production. Here, we used an improved dual-channel reaction chamber technique to measure net photochemical O production rate (P(O)) directly in Dongguan, a typical industrial city in China.

Optical fiber sensor for wearable and accurate human respiratory monitoring.

Accurate respiratory monitoring is of great significance in assessing and analyzing physical health, and preventing respiratory diseases. The recently emerged wearable respiratory sensors are confronted with the challenges such as complex fabrication processes, limited accuracy, and stringent wearing requirements. An optical fiber sensor for accurate human respiratory monitoring is proposed and experimentally verified.

Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.

Pulmonary fibrosis is a formidable challenge in chronic and age-related lung diseases. Myofibroblasts secrete large amounts of extracellular matrix and induce pro-repair responses during normal wound healing. Successful tissue repair results in termination of myofibroblast activity via apoptosis; however, some myofibroblasts exhibit a senescent phenotype and escape apoptosis, causing over-repair that is characterized by pathological fibrotic scarring.

Characterization of phosphate modified red mud-based composite materials and study on heavy metal adsorption.

In this paper, Bayer red mud (RM) and lotus leaf powder (LL) were used as the main materials, and KHPO was added to modify the material. Under the condition of high-temperature carbonization, RMLL was prepared and phosphate modified red mud matrix composite (PRMLL) was prepared based on KHPO modification, which can effectively remove Pb from water. The optimum preparation and application conditions were determined through orthogonal experiment: dosage 0.

Centennial Records of Microplastics in Lake Cores in Huguangyan Maar Lake, China.

Microplastic records from lake cores can reconstruct the plastic pollution history. However, the associations between anthropogenic activities and microplastic accumulation are not well understood. Huguangyan Maar Lake (HML) is a deep-enclosed lake without inlets and outlets, where the sedimentary environment is ideal for preserving a stable and historical microplastic record.

A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX.

Idiopathic pulmonary fibrosis is a progressive and age-related disease that results from impaired lung repair following injury. Targeting senescent myofibroblasts with senolytic drugs attenuates pulmonary fibrosis, revealing a detrimental role of these cells in pulmonary fibrosis. The mechanisms underlying the occurrence and persistence of senescent myofibroblasts in fibrotic lung tissue require further clarification.

Significantly underestimated traffic-related ammonia emissions in Chinese megacities: Evidence from satellite observations during COVID-19 lockdowns.

Ammonia (NH) plays an important role in the formation of atmospheric particulate matter, but the contribution of traffic-related emissions remains unclear, particularly in megacities with a large number of vehicles. Taking the opportunity of the stringent COVID-19 lockdowns implemented in Beijing and Shanghai in 2022, this study aims to estimate the traffic-related NH emissions in these two megacities based on satellite observations. Differences between urban and suburban areas during the lockdown and non-lockdown periods are compared.