Publications by authors named "Min Rui"

Purpose: This study aimed to investigate the risk factors and predictors of non-obese fatty liver disease in the Chinese population.

Patients And Methods: A total of 6,014 adults who underwent physical examinations at Union Hospital of Huazhong University of Science and Technology from March 2019 to March 2023 were included in this study. Fatty liver disease was diagnosed based on at least two of the following criteria: diffuse echo patterns relative to the liver, spleen, and kidney; ultrasonic beam attenuation; and poor intrahepatic visual details.

View Article and Find Full Text PDF

Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized-sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO@SiO@PDA (CSP) nanoparticles.

View Article and Find Full Text PDF

The Baculovirus Expression Vector System (BEVS) is highly valued in vaccine development, protein engineering, and drug metabolism research due to its biosafety, operational convenience, rapid scalability, and capacity for self-assembling virus-like particles. However, increasing cell density at the time of inoculation severely compromises the production capacity of BEVS, resulting in the "cell density effect". This study aimed to explore the mechanisms of the cell density effect through time-series analysis of transcriptomes and proteomes, with the goal of overcoming or alleviating the decline in productivity caused by increased cell density.

View Article and Find Full Text PDF

Artificial bone graft stands out for avoiding limited source of autograft as well as susceptibility to infection of allograft, which makes it a current research hotspot in the field of bone defect repair. However, traditional design and manufacturing method cannot fabricate bone scaffold that well mimics complicated bone-like shape with interconnected porous structure and multiple properties akin to human natural bone. Additive manufacturing, which can achieve implant's tailored external contour and controllable fabrication of internal microporous structure, is able to form almost any shape of designed bone scaffold via layer-by-layer process.

View Article and Find Full Text PDF
Article Synopsis
  • - Intestinal stem cells (ISCs) play a key role in gut health and recovery from damage, and research showed that Gelsolin KO mice experience more damage and fewer ISCs after radiation exposure.
  • - The study found that the absence of Gelsolin leads to decreased function of ISCs and shuts down the IL-17 signaling pathway, which is crucial for the differentiation of Th17 cells.
  • - Gelsolin supports Th17 cell functionality through the p-STAT3/RORγt pathway, enhancing ISC regeneration and providing protection against various intestinal injuries, not just radiation-induced ones.
View Article and Find Full Text PDF

Multiple myeloma (MM) is a highly heterogeneous hematological malignancy that is currently incurable. Individualized therapeutic approaches based on accurate risk assessment are essential for improving the prognosis of MM patients. Nevertheless, current prognostic models for MM exhibit certain limitations and prognosis heterogeneity still an unresolved issue.

View Article and Find Full Text PDF

Yellowing is the key processing technology of yellow tea, and environmental conditions have a significant impact on the yellowing process. In this study, volatile compounds of the yellowing process under different environmental conditions were analyzed by GC-MS. Results showed that a total of 75 volatile compounds were identified.

View Article and Find Full Text PDF
Article Synopsis
  • * Genetic findings show that ancient populations from northern Yunnan had closer ties to northern East Asia, indicating migration patterns through the Tibetan-Yi corridor since the Neolithic era.
  • * The research also revealed that central Yunnan maintained distinct genetic lineages over thousands of years, while the Xingyi site experienced a shift in mitochondrial DNA haplogroups from those in the Yellow River region to those found in coastal southern China between the Late Neolithic and Bronze Age.
View Article and Find Full Text PDF

Lactones has gained increasing attention in recent years due to wide application in polymer and pharmaceutical industries. Traditional synthetic methods of lactones often involve harsh operating temperature, use of strong alkalis and toxic oxidants. Therefore, lactonization of diols under milder conditions have been viewed as the most promising route for future commercialization.

View Article and Find Full Text PDF

The healing of bone defects among diabetic patients presents a critical challenge due to the pathological microenvironment, characterized by hyperglycemia, excessive reactive oxygen species (ROS) production, and inflammation. Herein, multifunctional composite microspheres, termed GMAP are developed, using a microfluidic technique by incorporating Au@Pt nanoparticles (NPs) and GelMA hydrogel to modulate the diabetic microenvironment for promoting bone regeneration. The GMAP enables the sustained release of Au@Pt NPs, which function as bimetallic nanozymes with dual enzyme-like activities involving glucose oxidase and catalase.

View Article and Find Full Text PDF

Microplastic (MP) is an emerging pollutant that has attracted attention in the environmental field, and the research of MPs in freshwater systems needs to be strengthened. To characterize the MPs in surface water and sediments of the western urban river network, water and sediment samples were collected. The results showed that the abundance of MPs in the water body of the river network ranged from 7 to 172 n/L, whereas the abundance of MPs in the sediments ranged from 7 to 144 n/kg, and the average abundance in the dry season was significantly higher than that in the rainy season.

View Article and Find Full Text PDF

Introduction: Non-attendance with scheduled postoperative follow-up visits remains a common issue in orthopaedic clinical research. The objective of this study was to identify the risk factors associated with loss to follow-up among elderly patients with hip-fracture postoperatively.

Methods: A retrospective analysis of 1-year post-surgery was performed on patients aged over 60 years who underwent hip-fracture surgery from January 2017 to March 2019.

View Article and Find Full Text PDF

Array waveguide gratings (AWGs) have been widely used in multi-purpose and multi-functional integrated photonic devices for Microwave photonics (MWP) systems. In this paper, we compare the effect of output waveguide configurations on the performance of AWGs. The AWG with an output waveguide converging on the grating circle had larger crosstalk and lower nonuniformity.

View Article and Find Full Text PDF

Ammonia nitrogen is a common pollutant in water and soil, known for its biological toxicity and complex removal process. Traditional biological methods for removing ammonia nitrogen are often inefficient, especially under varying temperature conditions. This study reviews physicochemical techniques for the treatment and recovery of ammonia nitrogen from water.

View Article and Find Full Text PDF

The progression of lung adenocarcinoma (LUAD) from atypical adenomatous hyperplasia (AAH) to invasive adenocarcinoma (IAC) involves a complex evolution of tumour cell clusters, the mechanisms of which remain largely unknown. By integrating single-cell datasets and using inferCNV, we identified and analysed tumour cell clusters to explore their heterogeneity and changes in abundance throughout LUAD progression. We applied gene set variation analysis (GSVA), pseudotime analysis, scMetabolism, and Cytotrace scores to study biological functions, metabolic profiles and stemness traits.

View Article and Find Full Text PDF

The bone immune microenvironment can influence the occurrence and progression of bone defects. To date, research on promoting macrophage M2 polarization to improve bone injury repair has been insufficient. In this study, we designed an injectable poly(L-lactic acid) (PLLA) porous microsphere that forms calcium phosphate crystals on its surface by binding to melatonin, followed by bionanomimetic mineralization .

View Article and Find Full Text PDF

The pervasive global issue of population aging has led to a growing demand for health monitoring, while the advent of electronic wearable devices has greatly alleviated the strain on the industry. However, these devices come with inherent limitations, such as electromagnetic radiation, complex structures, and high prices. Herein, a Solaris silicone rubber-integrated PMMA polymer optical fiber (S-POF) intelligent insole sensing system has been developed for remote, portable, cost-effective, and real-time gait monitoring.

View Article and Find Full Text PDF

Unlabelled: Cannabis grains are frequently reported from archaeological sites in Asia, and hypothesized centers of origins are China and Central Asia. Chinese early cannabis remains are often interpreted as evidence of hemp fabric production, in line with early textual evidence describing ritualistic hemp cloth use and hemp cultivation as a grain crop. Modern measurements on cannabis varieties show distinct sizes between fibre or oil/fibre and psychoactive varieties, the former having larger seeds on average than the latter.

View Article and Find Full Text PDF

Background: The World Health Organization (WHO) published the Integrated Care for Older People (ICOPE) framework to help healthcare providers cope with the population aging crisis. However, the relevant evidence on the demands of older people and the compensatory capacity of the environment is limited. This study reports for the first time the level of the ICOPE demand in Western China that includes the impact of geographic accessibility of medical resources (GAMR) on ICOPE demand and the potential mechanism of health status.

View Article and Find Full Text PDF

This study aimed to determine lncRNA SNHG14 and miR-206 in Thyroid Cancer ( TC) and to explore the related mechanisms. Sixty-four samples of thyroid tissue were collected from patients with TC. TC cell lines and a normal human thyroid cell line (HTori-3) were bought.

View Article and Find Full Text PDF

Infectious bursal disease (IBD) of chickens is an acute, high-contact, lytic infectious disease caused by infectious bursal disease virus (IBDV). The attenuated inactivated vaccine produced by DF-1 cells is an effective control method, but the epidemic protection demands from the world poultry industry remain unfulfilled. To improve the IBDV vaccine production capacity and reduce the economic losses caused by IBDV in chicken, cellular metabolic engineering is performed on host cells.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how tacrolimus affects proteinuria in patients suffering from idiopathic membranous nephropathy (IMN), using a machine learning model for analysis.
  • Data collected from existing literature and 463 IMN patients was analyzed to determine the drug's effectiveness based on changes in proteinuria levels.
  • Results indicate that to achieve optimal therapeutic effects, tacrolimus concentrations should be maintained within the range of 4-10 ng/ml for a minimum of 1.72 months.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how to optimize cyclosporin dosing for pediatric refractory nephrotic syndrome (PRNS), considering the impact of spironolactone, a drug known to influence cyclosporin metabolism.
  • Using a Monte Carlo simulation, researchers developed dosing regimens tailored to different body weights for patients with and without spironolactone.
  • The findings suggest specific dosing adjustments for cyclosporin in PRNS to enhance treatment effectiveness and ensure safe drug concentration levels in young patients.
View Article and Find Full Text PDF

Inflammation and immune responses play important roles in cancer development and prognosis. We identified 59 upregulated inflammation- and immune-related genes (IIRGs) in clear cell renal cell carcinoma (ccRCC) from The Cancer Genome Atlas database. Among the upregulated IIRGs, nucleotide binding oligomerization domain 2 (NOD2), PYD and CARD domain (PYCARD) were also confirmed to be upregulated in the Oncomine database and in three independent GEO data sets.

View Article and Find Full Text PDF

The increasing demand for individualized health monitoring and diagnostics has prompted considerable research into the integration of portable optical fiber biosensors integrated with smartphones. By capitalizing on the benefits offered by optical fibers, these biosensors enable qualitative and quantitative biosensing across a wide range of applications. The integration of these sensors with smartphones, which possess advanced computational power and versatile sensing capabilities, addresses the increasing need for portable and rapid sensing solutions.

View Article and Find Full Text PDF