Publications by authors named "Min Meng"

In areas where there is high humidity and freezing rain, there is a tendency of blade icing on wind turbines. It results in energy dissipation and mechanical abrasion and also creates a safety concern due to the risk of having falling ice. Real-time online detection of icing is crucial in the enhancement of power generation efficiency and in the safety of wind turbines.

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This paper investigates a distributed aggregative optimization problem subject to coupling affine inequality constraints, in which local objective functions depend not only on their own decision variables but also on an aggregation of all the agents' variables. The formulated problem encompasses numerous practical applications, such as commodity distribution, electric vehicle charging, and energy consumption control in power grids. Hence, there is a compelling need to explore a new neurodynamic approach to address this.

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The control properties of discrete-time switched linear systems (SLSs) with switching signals generated by logical dynamical systems are studied using the semitensor product (STP) approach. With the algebraic state-space representation (ASSR), the linear modes and the logical generators are aggregated as a system with hybrid states, leading to the criteria of reachability, controllability, observability, and reconstructibility of the SLSs. Algorithms for checking these properties are given.

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Carbapenem- and colistin-resistant Escherichia coli (CCREC) cause high mortality rates and health costs, and have become serious health concerns. Total 1764 samples were collected from 60 animal farms in 2019 and 2021, including worker and animal faeces, wastewater, well water, air, vegetables, human hands, object surfaces, throat swabs, soil, and flies to investigate the prevalence and potential transmission pathways of CCREC. Eleven CCREC were detected: 9 (5 in 2019 and 4 in 2021) from 5 worker faeces, 3 animal faeces, 1 wastewater, and 2 from 1 flies sample.

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Background: Previously, we developed the Guidelines for the Management of Pediatric Off-Label Use of Drugs in China in addressing the need for standardization of pediatric off-label drug use. As the implementation of recommendations in Guidelines among healthcare professionals is weak, it is important to identify barriers to guideline implementation for developing appropriate strategies for specific settings and target groups. This study aimed to assess the difficulty and urgency in implementing the recommendations in the Guideline, identifying the factors affecting the implementation of these recommendations to realize the clinical translation of the Guideline.

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Objective: To systematically evaluate the efficacy and safety of anlotinib targeted therapy for the treatment of patients with advanced digestive system neoplasms (DSNs).

Methods: Clinical trials were extracted from PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI) and the Wanfang database up to October 2023. Outcome measures, including therapeutic efficacy, quality of life (QOL) and adverse events, were extracted and evaluated.

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During a sepsis infection, the lung is extremely susceptible to damage. A condition known as acute respiratory distress syndrome (ARDS) may develop in extreme circumstances. The primary objective of this research is to identify important genes that are related with both sepsis and lung injury.

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Hospital-acquired pressure ulcers (HAPUs) are still an important worldwide issue related to the safety and quality of patient care, which are among the top five adverse events reported. Patients who develop HAPUs have longer stays in the hospital than necessary, are at a greater risk of infections, and are more likely to die. Surgical patients are prone to developing PUs because they often remain immobile for extended periods of time, and their surgical procedures may limit the flow of blood oxygen and nutrition and lead to a decrease in muscle tone.

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The metabolic breakdown of propiconazole by fungi was examined, and it was found that the microbial model (Cunninghamella elegans ATCC36112) efficiently degrades the triazole fungicide propiconazole through the action of cytochrome P450. This enzyme primarily facilitates the oxidation and hydrolysis processes involved in phase I metabolism. We observed major metabolites indicating hydroxylation/oxidation of propyl groups of propiconazole.

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Domain adaptation has shown appealing performance by leveraging knowledge from a source domain with rich annotations. However, for a specific target task, it is cumbersome to collect related and high-quality source domains. In real-world scenarios, large-scale datasets corrupted with noisy labels are easy to collect, stimulating a great demand for automatic recognition in a generalized setting, i.

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Objective: To examine the current prevalence and cost of paediatric off-label drug prescriptions in Gansu, China, and the potential influencing factors.

Design: The prevalence of off-label prescriptions in paediatrics was evaluated according to the National Medical Products Administration drug instructions in the China Pharmaceutical Reference (China Pharmaceutical Reference, MCDEX) database. The evidence of the prescription was determined by existing clinical practice guidelines and the Thomson Grade in the Micromedex 2021 compendium.

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Background And Aims: The association of blood transfusion with an increase in medium- and short-term mortality in specific populations has been confirmed. However, the correlation between blood transfusion and long-term mortality in the general population remains unclear. This cohort study evaluated the correlation between blood transfusion and overall and cause-specific mortality in the general American adult population.

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Background: Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis. To date, only approximately 100 patients have been reported in the English literature. The prognosis of this tumor type is poor, the preoperative diagnosis is difficult, and there is a possibility of a misdiagnosis.

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Article Synopsis
  • - The OSNA assay, which measures CK19 mRNA levels, is important for diagnosing sentinel lymph node (SLN) metastases in cancers where CK19 is expressed, evaluating its effectiveness through a meta-analysis of 61 studies involving over 7,000 patients.
  • - The analysis found OSNA's pooled sensitivity was 87% and specificity was 95%, with the accuracy affected by CK19 levels in normal tissues, particularly benefiting breast cancer diagnoses.
  • - The findings suggest OSNA is a reliable method to detect SLN metastases across various cancers and populations, highlighting the need for further clinical investigations into its application.
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Background: Despite being a global public health concern, there is a research gap in analyzing implementation strategies for managing off-label drug use in children. This study aims to understand professional health managers' perspectives on implementing the Guideline in hospitals and determine the Guideline's implementation facilitators and barriers.

Methods: Pediatric directors, pharmacy directors, and medical department directors from secondary and tertiary hospitals across the country were recruited for online interviews.

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Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical symptoms and delaying disease progression but have not shown significant therapeutic effects in patients with lung diseases. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) isolated from the human UC have the capacity for self-renewal and multilineage differentiation.

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Thyroid cancer (TC) is the most frequent malignancy of the endocrine system. Apatinib, as an anti-angiogenic agent, has been applied in the therapy of several cancers. However, the function and mechanism of Apatinib in TC have not been clearly elucidated.

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RBD1016 is an -acetylgalactosamine-conjugated siRNA drug currently in a phase II trial for treatment of chronic hepatitis B virus. To evaluate its absorption, distribution, metabolism and excretion (ADME) and pharmacokinetic/pharmacodynamic (PK/PD) properties, two LC-based bioanalytical methods, LC-high-resolution/accuracy MS and LC-fluorescence detection, were developed and qualified. The LC-high-resolution/accuracy MS method was used for metabolite identification and simultaneous quantitation of the antisense and sense strands as well as their respective metabolites.

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Objectives: The study of postoperative liver decompensation after microwave ablation (MWA) for hepatocellular carcinoma (HCC) in patients with clinically significant portal hypertension (CSPH) is still lacking. The purpose of the present study was to compare the postoperative liver decompensation after MWA and laparoscopic resection (LR) for HCC in patients with CSPH.

Methods: The present retrospective study enrolled 222 HCC patients with CSPH who underwent MWA (n = 67) or LR (n = 155).

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Article Synopsis
  • * A study on the metabolism of tebuconazole in Cunninghamella elegans showed that about 98% of it was degraded within 7 days, resulting in five identified metabolites.
  • * The study identified cytochrome P450 and flavin-dependent monooxygenase as key enzymes in the metabolic process, providing insights for understanding the toxicological effects and potential bioremediation of tebuconazole.
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  • * The study examined the presence of 49 antibiotics, 9 antibiotic resistance genes (ARGs), and metals in soil and sediments, finding significant positive correlations between certain antibiotics and their corresponding ARGs, indicating selective pressure in these environments.
  • * Key contributors to antibiotic resistance include sheep and poultry farming, as well as fish farming, suggesting the need for increased management practices to mitigate the enrichment of ARGs during land development in these coastal areas.
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Introduction: Microwave ablation (MWA) is an effective and safe approach for the treatment of ground-glass nodule (GGN)-like lung cancer, but long-term follow-up is warranted. Therefore, this multi-center retrospective study aimed to evaluate the results of MWA for the treatment of peripheral GGN-like lung cancer with a long-term follow-up.

Materials And Methods: From June 2013 to January 2018, a total of 87 patients (47 males and 40 females, mean age 64.

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Article Synopsis
  • Wastewater treatment plants (WWTPs) are crucial in the spread of antibiotic-resistant bacteria (ARB) and genes (ARGs), serving as hubs for contaminants from humans, animals, and the environment.
  • A year-long study assessed variations and factors influencing ARB, specifically focusing on ESBL-producing E. coli, revealing significant detection of this bacteria across various WWTP sections and connecting rivers.
  • Seasonal changes and temperature inversely affected the detection rates of ESBL-Ec, with concerning levels found in rivers highlighting a public health risk; clonal transmission of these bacteria between the WWTP and rivers was also observed, underscoring the need for ongoing monitoring.
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The increasing prevalence of infections caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae strains (CR-hvKP) prompts the question of whether these strains also circulate outside of clinical settings. However, the environmental occurrence and dissemination of CR-hvKP are poorly studied. In the current study, we investigated the epidemiological characteristics, and dissemination dynamics of carbapenem-resistant K.

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Article Synopsis
  • Carbapenem-resistant Enterobacteriaceae (CRE), particularly Citrobacter spp. (CRCS), pose significant health risks and are poorly studied compared to Klebsiella pneumoniae and Escherichia coli.
  • A year-long study in Shandong Province, China, detected 14 CRCS isolates across various locations in an urban wastewater treatment plant (WWTP) and connecting rivers, with Citrobacter braakii being the most common.
  • Findings revealed clonal transmission of CRCS between the WWTP and rivers, raising concerns about potential exposure risks for local residents, while also indicating that NDM-5-producing C. sedlakii might be prevalent across different regions in China.
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