Ultraviolet Photodetector Fabrication with Low-Power Dissipation Based on Organic Suboptimal Source-Gated Transistor Architecture and MoO-Doped Pentacene.

Organic field-effect transistor (OFET)-based photodetectors have been extensively studied owing to their potential applications in various fields, such as imaging, communication, and environmental monitoring. However, the traditional OFET structure brings about high power consumption. Furthermore, their low electrical performance and light sensitivity must be improved to detect harmful UV rays that accelerate skin aging and cause vision degradation.

Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial‑dependent apoptotic pathway and reducing αβ integrin‑mediated adhesion in HT‑29 human colorectal cancer cells.

Colon cancer is one of the most frequent malignant neoplasms worldwide. Epidemiological studies suggested that the development of colon cancer can be prevented by plant‑derived ingredients. In the present study, the chemopreventive activity of buddlejasaponin IV (BS‑IV), isolated from the aerial part of , was investigated using cell viability, DNA fragmentation, caspase‑3 activity, anoikis, cell adhesion, and flow cytometry assays and a murine lung metastasis model.

Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8.

Platycodin D is a major constituent in the root of and has diverse pharmacologic activities, including anti-inflammatory, anti-allergic, and antitumor activities. Vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are potent angiogenic factors and contribute to tumor angiogenesis by directly and indirectly promoting angiogenic processes, including the proliferation, adhesion, migration, and tube formation of endothelial cells. Here, we found that platycodin D at noncytotoxic concentrations inhibited VEGF-induced proliferation, adhesion to the extracellular matrix proteins fibronectin and vitronectin, chemotactic motility, and tube formation of human umbilical vein endothelial cells (HUVECs).

Transforming growth factor-β-regulated fractalkine as a marker of erosive bone invasion in oral squamous cell carcinoma.

Patients with oral squamous cell carcinoma (OSCC) bone invasion are surgically treated with bone resection, which results in severe physical and psychological damage. Here, we investigated the potential of fractalkine (CX3CL1), which is regulated by transforming growth factor (TGF-β), as a novel biomarker for correct prediction and early detection of OSCC-associated bone invasion. TGF-β knockdown and treatment with a TGF-β-neutralizing antibody decreased the level of fractalkine in the culture media of HSC-2 and YD10B OSCC cells.

The downregulation of IGFBP3 by TGF-β signaling in oral cancer contributes to the osteoclast differentiation.

Oral squamous cell carcinoma (OSCC) frequently invades nearby bone and bone involvement determines the prognosis of patients. Growth factors, stored in the bone matrix and released during bone destruction, are known as key components in the bone-tumor interaction. However, the coordination of growth factor signals and the precise mechanism of bone destruction in oral cancer are still unclear.

Effects of Family Meal Frequency on Risk Factors for Cardiovascular Disease in Korean Elderly Males and Females.

Background: In the case of the elderly who highly depend on family, serious health problems can be caused due to the reduction of family meals. Therefore, this study aims to suggest the fundamental data for management of cardiovascular disease, one of the major causes of death in elderly Koreans, by investigating the effects of family meal frequency on the risk factors for cardiovascular disease in Korean elderly males and females.

Methods: The raw data of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES III) were utilized.