Publications by authors named "Min Jeong Gu"

Background: The and anti-inflammatory and anti-oxidative effects of an amino acid (AA) blend (tryptophan, threonine, and methionine) in pigs.

Objective: This study aimed to evaluate the anti-inflammatory and anti-oxidative effects of an AA blend on intestinal porcine epithelial cells (IPEC-J2) and the anti-inflammatory and anti-oxidative effects in pigs experimentally challenged with .

Methods: IPEC-J2 were pretreated with an AA blend for 25 h and then treated with lipopolysaccharide (LPS), deoxynivalenol (DON), or HO for evaluation.

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  • * In cell studies, phage EK99P-1 was effective in reducing ETEC K99-induced damage to the intestinal barrier and preventing the loss of tight junction proteins.
  • * The phage treatment also decreased the secretion of inflammatory cytokines, suggesting it modulates immune responses, thus helping to reinforce intestinal health during ETEC K99 infection.
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Vaccination has been recently attracted as one of the most successful medical treatments of the prevalence of many infectious diseases. Mucosal vaccination has been interested in many researchers because mucosal immune responses play part in the first line of defense against pathogens. However, mucosal vaccination should find out an efficient antigen delivery system because the antigen should be protected from degradation and clearance, it should be targeted to mucosal sites, and it should stimulate mucosal and systemic immunity.

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  • Scrub typhus is caused by a trombiculid mite bite that infects humans, and pneumonia is commonly seen in affected patients.
  • Researchers explored the effectiveness of intranasal vaccination with an outer membrane protein (OMPOT) to protect against this infection.
  • The study found that this vaccination prompted strong immune responses and provided protective immunity against scrub typhus-related pneumonia in mice.
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Purpose: Despite the prevalent use of insulin pump therapy worldwide, few studies have been conducted among young patients with type 1 diabetes (T1D) in Korea. We investigated the durability and effectiveness of insulin pump therapy among Korean pediatric and young adult patients with T1D.

Methods: This study included 54 patients with T1D diagnosed at pediatric ages (range, 1.

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Monocytes/macrophages, which are found in a variety of organs, maintain tissue homeostasis at a steady state and act as the first line of defence during pathogen-induced inflammation in the host. Most monocyte/macrophage lineage studies in chickens have been largely performed using cell lines, while few studies using primary cells have been conducted. In the present study, the phenotypic and functional characteristics of splenic monocyte/macrophage lineage cells during steady state and inflammatory conditions were examined.

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Fumonisin B (FB), mainly produced by Fusarium verticillioides and Fusarium proliferatum, can be converted to the less toxic metabolite hydrolyzed FB (HFB) by enzymatic degradation. The application of an FBdegrading enzyme as a feed additive is a strategy to reduce fumonisin exposure of animals. However, the difference between the effect of FB and HFB on porcine intestinal immunity is poorly documented.

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  • The bursa of Fabricius is a unique organ in birds essential for B cell development, allowing researchers to study B cell differentiation throughout various stages.
  • Recent research indicates that during late embryonic development and hatching, the number and size of bursal B cells change, with a notable reversal in proportions between small and large B cells.
  • Findings suggest that larger B cells are more actively proliferating and express higher levels of genes associated with proliferation and differentiation, indicating they play a crucial role in B cell development in chickens.
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Cysteine-X-cysteine (CXC) motif chemokine ligand 12 (CXCL12) and its receptor, CXC chemokine receptor type 4 (CXCR4), are involved in regulating the proliferation, migration, and survival of trophoblast cells and the maternal immune response in humans and mice. The present study examined the expression, regulation, and function of CXCL12 and CXCR4 at the maternal-conceptus interface during pregnancy in pigs. The endometrium expressed CXCL12 and CXCR4 mRNAs with the greatest CXCL12 abundance on Day 15 of pregnancy.

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  • The study investigates the relationship between gut microbiota and regulatory T cells (Tregs) in chickens, focusing on how antibiotics affect Treg populations.
  • Researchers found that treating chickens with antibiotics significantly reduced certain Treg cell types in their cecal tonsils, linking these changes to Gram-positive bacteria like Clostridia.
  • Supplementing the antibiotic-treated chickens with acetate helped recover the Treg populations, highlighting the role of acetate and its receptor GPR43 in regulating T cell activity in the gut.
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γδ T cells, known to be an important source of innate IL-17 in mice, provide critical contributions to host immune responses. Development and function of γδ T cells are directed by networks of diverse transcription factors (TFs). Here, we examine the role of the zinc finger TFs, Kruppel-like factor 10 (KLF10), in the regulation of IL-17-committed CD27 γδ T (γδ-17) cells.

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Chemokines play critical roles in the establishment and maintenance of pregnancy in animals. Cysteine-X-cysteine motif chemokine ligand 9 (CXCL9), CXCL10, and CXCL11 are involved in recruiting immune cells by binding to their shared receptor, CXC receptor 3 (CXCR3), in a variety of tissues. This study examined the expression and regulation of chemokines CXCL9, CXCL10, and CXCL11, their receptor CXCR3, and their role at the maternal-conceptus interface in pigs.

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  • The study focuses on porcine epidemic diarrhea virus (PEDV), which causes severe diarrhea and dehydration in pigs by invading intestinal cells.
  • Researchers found that increasing a cellular process called autophagy with the drug rapamycin can suppress PEDV infection in these intestinal cells without harming cell viability.
  • The findings suggest that rapamycin could be a potential treatment to prevent PEDV infections by promoting autophagy and protecting against cell death caused by the virus.
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Organic acids have long been known for their beneficial effects on growth performance in domestic animals. However, their impact on immune responses against viral antigens in chickens is unclear. The present study aimed to investigate immunological parameters in broilers immunized with a H9N2 vaccine and/or fed a diet containing organic acids (citric, formic, and lactic acids).

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Objective: This study was performed to evaluate whether ambient temperature and dietary glycerol addition affect growth performance, and blood metabolic and immunological parameters, in beef cattle.

Methods: Twenty Korean cattle steers (405.1±7.

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  • Modern intensive livestock production can introduce various stressors that negatively impact animal health and growth, including environmental factors, nutrition, and infections.
  • Stress from heat and nutritional issues can compromise gut health by increasing permeability and inflammatory responses, while fasting and toxins affect gut barrier function differently.
  • Recent findings suggest that while certain probiotic supplements can mitigate stress from infections like ETEC, a deeper understanding of how gut and systemic immune systems interact under these stress conditions is still needed.
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This study examined the effects of road transportation on metabolic and immunological responses in dairy heifers. Twenty Holstein heifers in early pregnancy were divided into non-transported (NT; n = 7) and transported (T; n = 13) groups. Blood was collected before transportation (BT), immediately after transportation for 100 km (T1) and 200 km (T2), and 24 h after transportation (AT).

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Intestinal barrier is the first line of defense inside the body and comprises intercellular tight junction (TJ) proteins that regulate paracellular permeability. Deoxynivalenol (DON), a fungal metabolite often found in the contaminated food of domestic animals, is known to impair intestinal barrier function and may be involved in intestinal inflammation. Unlike in humans and mice, the importance of Toll-like receptor (TLR) 2 expressed in porcine intestinal epithelial cells is largely unclear.

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A successful delivery of antigen through oral route requires to overcome several barriers, such as enzymatic barrier of gastrointestinal tract and epithelial barrier that constitutes of microfold cells (M cells) for antigen uptake. Although each barrier represents a critical step in determining the final efficiency of antigen delivery, the transcytosis of antigen by M cells in the follicle-associated epithelium (FAE) to Peyer's patches appears to be a major bottleneck. Considering the systemic administration of receptor activator of nuclear factor (NF)-ĸB ligand (RANKL) induces differentiation of receptor activator of nuclear factor (NF)-ĸB (RANK)-expressing enterocytes into M cells, here, we illustrated a promising approach of antigen delivery using full length transmembrane RANKL (mRANKL).

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Ginsenosides, the major active component of ginseng, are traditionally used to treat various diseases, including cancer, inflammation, and obesity. Among these, compound K (CK), an intestinal bacterial metabolite of the ginsenosides Rb1, Rb2, and Rc from Bacteroides JY-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. However, the precise effect of CK on breast cancer cells remains unclear.

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Background: Panax ginseng (i.e., ginseng) root is extensively used in traditional oriental medicine.

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Intestinal epithelial cells (IECs) forming the barrier for the first-line of protection are interconnected by tight junction (TJ) proteins. TJ alteration results in impaired barrier function, which causes potentially excessive inflammation leading to intestinal disorders. It has been suggested that toll-like receptor (TLR) 2 ligands and some bacteria enhance epithelial barrier function in humans and mice.

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Background: The aim of this study is to evaluate the effect of a web-based comprehensive information system, consisting of Internet and cellular phone use, on blood glucose control.

Methods: We established eMOD (electronic Management of Diabetes), a web-based ubiquitous information system, for cell phone users along with a website for Internet users to provide diabetes education. We examined whether this information system has the same impact on glycemic control as conventional education for the diabetes patient.

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