Publications by authors named "Min Hoon Lee"
Article Synopsis
- The rising threat of smallpox bioterrorism and concerns over side effects from current live-virus vaccines highlight the need for new vaccines with improved efficacy.
- This study focused on using DNA vaccines with specific antigen-encoding plasmids, which can reduce risks associated with traditional live-virus vaccines.
- Findings showed that adding B-type CpG oligodeoxynucleotides (ODNs) as TLR9 ligands enhanced the immune response and protective effects of the L1R DNA vaccine against Orthopoxvirus in mice, making it a promising method for smallpox immunization.
The potential use of biological agents has become a major public health concern worldwide. According to the CDC classification, Bacillus anthracis and Clostridium botulinum, the bacterial pathogens that cause anthrax and botulism, respectively, are considered to be the most dangerous potential biological agents. Currently, there is no licensed vaccine that is well suited for mass immunization in the event of an anthrax or botulism epidemic.
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