Publications by authors named "Min Ge"

Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms. In this study, phenotypically stable SCV strains are successfully recovered from clinical specimens, characterized by elevated drug resistance and reduced immunogenicity.

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  • Dentin hypersensitivity occurs when exposed dentin, often due to a lack of enamel, reacts to external stimuli, causing discomfort.
  • A new treatment using gelatin-modified bioactive glass (MBG@PDA@Gel) effectively blocks dentin tubules and promotes mineralization, showing better results than the traditional agent Gluma in lab tests.
  • Animal studies revealed that MBG@PDA@Gel not only remineralizes demineralized dentin effectively but also remains stable in the oral cavity, enhancing the biocompatibility of the material.
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Introduction: Corrected QT interval (QTc) is a ventricular repolarization marker on electrocardiography. Previous studies evaluated its value in predicting atrial fibrillation (AF) occurrence. However, its predictive efficacy for AF recurrence remains controversial.

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Background: Despite the positive effect of early post-cardiac surgery exercises, the concern of safety issues is high, indicating the need for standardized and quantitative mobility indicators to enhance early mobilization monitoring in the intensive care unit while ensuring patient safety. This study aimed to compare the safety and efficacy of quantitative phase I exercise versus usual care in patients who have undergone cardiac surgery.

Methods: In this non-randomized, single-blind trial, patients following on-pump cardiac surgery were allocated to either quantitative exercise (intervention group, n=114) or usual care (control group, n=114) based on their willingness.

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In the competition between the pathogen infection and the host defense, infectious microorganisms may enter the host cells by evading host defense mechanisms and use the intracellular biomolecules as replication nutrient. Among them, intracellular relies on the host cells to protect itself from the attacks by antibiotics or immune system to achieve long-term colonization in the host, and the consequent clinical therapeutic failures and relapses after antibiotic treatment. Here, we demonstrate that intracellular surviving well even in the presence of vancomycin can be effectively eliminated using an emerging cell-mimicking therapeutic strategy.

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  • After cardiac surgery, 10%-70% of patients may experience diaphragmatic dysfunction, impacting recovery times and leading to respiratory complications, necessitating further investigation into its effects and risk factors.
  • A study analyzed the diaphragmatic function of 177 patients using ultrasound, defining dysfunction based on specific movement and thickness metrics, while considering various medical data.
  • The results indicated a 40.7% rate of early postoperative diaphragmatic dysfunction, with affected patients requiring more oxygen and showing trends toward longer ICU and hospital stays compared to those without dysfunction.
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Superconductors, an essential class of functional materials, hold a vital position in both fundamental science and practical applications. However, most superconductors, including MgB, BiSrCaCuO, and FeSe, are highly sensitive to environmental attacks (such as from water and moist air), hindering their wide applications. More importantly, the surface physical and chemical processes of most superconductors in various environments remain poorly understood.

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  • - Nitrogen (N) is crucial for plant health, acting as both a nutrient and a signaling molecule, and understanding its metabolism is key to improving maize N use efficiency.
  • - Two maize lines, B73 and Ki11, have different responses to low nitrogen and chlorate, with transcriptomic analysis showing varied expression patterns of nitrogen usage genes (NUGs) between them.
  • - Unique transcription factors (TFs) were identified, with 23 in B73 and 41 in Ki11; specifically, MADS26 in B73 significantly influences nitrate sensitivity, offering insights for breeding maize that uses nitrogen more efficiently.
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  • Antibiotic-resistant germs and infections that stick to surfaces in the body are causing big health problems around the world, and regular antibiotic treatments aren't working well sometimes.
  • New technologies using tiny materials, called nanotechnology, are being researched to help fight these infections better.
  • The review talks about different ways these tiny materials can help, such as using special reactions to kill germs and boosting the body's immune system, along with challenges and what could happen in the future with this science.
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  • Researchers are using metal-organic framework (MOF) nanoparticles to tackle challenges in treating antibiotic-resistant bacterial biofilm infections mainly found in medical implants.
  • These nanoparticles disrupt the bacteria's defenses against reactive oxygen species (ROS) and enhance immune responses by modifying the infection environment in a mouse model.
  • The study highlights a new therapeutic approach that combines ROS production and immune cell activation, showing promise for effectively eradicating tough infections that resist traditional treatments.
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Bacterial infections is one of the main factors delaying the wound healing, which has become a serious challenge for healthcare systems. Zinc oxide nanoparticles (ZnO NPs), which show broad-spectrum and excellent antibacterial activity, tend to aggregate easily and therefore hardly penetrate into bacterial biofilms, showing limited anti-biofilm properties. Herein,alginate (ALG) modified ZnO NPs (ZnO@ALG) were prepared via the combination of mussel-inspired method and "thiol-Michael" click reaction, which showed excellent dispersion and biocompatibility.

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Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that plays an important role in cancer cells biology. However, present EZH2 inhibitors in clinic have not achieved satisfactory efficacy. Herein, a number of EZH2-targeted PROTAC compounds were designed and synthesized by selecting different linkers, using Tazemetostat as the protein of interest (POI) portion of PROTAC molecules, hoping to improve the defects of existing EZH2 inhibitors effectively.

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Benefiting from the good electromechanical performance, ionic conductive hydrogel can easily convert the deformation into electrical signals, showing great potential in wearable electronic devices. However, due to the high water content, icing and water evaporation problems seriously limit their development. Although additives can ease these disadvantages, the accompanying performance degradation and complex preparation processes couldn't meet application needs.

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Biofilm-associated infections (BAIs) continue to pose a major challenge in the medical field. Nanomedicine, in particular, promises significant advances in combating BAIs through the introduction of a variety of nanomaterials and nano-antimicrobial strategies. However, studies to date have primarily focused on the removal of the bacterial biofilm and neglect the subsequent post-biofilm therapeutic measures for BAIs, rendering pure anti-biofilm strategies insufficient for the holistic recovery of affected patients.

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Molten NaF-BeF salt is widely considered a promising candidate to replace FLiBe in molten salt reactor applications, which is crucial to reducing the operating costs of the molten salt reactor. Studies on beryllium compounds are rarely conducted due to their volatility and high toxicity. Herein, the Be-F coordination structure of NaF/BeF mixed salts was investigated in-depth through various HT-NMR and solid-state NMR methods, which are optimized to be appropriate for the detection of beryllium compounds.

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Highly crystalline and easily feasible topological insulator-superconductor (TI-SC) heterostructures are crucial for the development of practical topological qubit devices. The optimal superconducting layer for TI-SC heterostructures should be highly resilient against external contamination and structurally compatible with TIs. In this study, we provide a solution to this challenge by showcasing the growth of a highly crystalline TI-SC heterostructure using refractory TiN (111) as the superconducting layer.

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Objective: The aim of this study is to conduct a systematic evaluation of the diagnostic efficacy of Breast Imaging Reporting and Data System (BI-RADS) 4 benign and malignant breast lesions using magnetic resonance imaging (MRI) radiomics.

Methods: A systematic search identified relevant studies. Eligible studies were screened, assessed for quality, and analyzed for diagnostic accuracy.

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Background: Postoperative acute kidney injury (PO-AKI) is a prevalent complication among patients with acute type A aortic dissection (aTAAD) for which unrecognized trajectories of renal function recovery, and their heterogeneity, may underpin poor success in identifying effective therapies.

Methods: This was a retrospective, single-center cohort study in a regional Great Vessel Center including patients undergoing aortic dissection surgery. Estimated glomerular filtration rate (eGFR) recovery trajectories of PO-AKI were defined through the unsupervised latent class mixture modeling (LCMM), with an assessment of patient and procedural characteristics, complications, and early-term survival.

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Periodontitis is a chronic disease caused by bacterial infection and is characterized with alveolar bone resorption. Bone regeneration in periodontitis remains a critical challenge because bacterial infection induced an unfavorable microenvironment for osteogenesis. Therefore, it is necessary to design proper therapeutic platforms to control bacterial infection and promote bone regeneration.

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Electrochemical C-N coupling reaction based on carbon dioxide and nitrate have been emerged as a new "green synthetic strategy" for the synthesis of urea, but the catalytic efficiency is seriously restricted by the inherent scaling relations of adsorption energies of the active sites, the improvement of catalytic activity is frequently accompanied by the decrease in selectivity. Herein, a doping engineering strategy was proposed to break the scaling relationship of intermediate binding and minimize the kinetic barrier of C-N coupling. A thus designed SrCoRuO catalyst achieves a urea yield rate of 1522 μg h mg and faradic efficiency of 34.

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Sustainable carbon dots based on cellulose, particularly carboxymethyl cellulose carbon dots (CMCCDs), were confined in an inorganic network resulting in CMCCDs@SiO. This resulted in a material exhibiting long afterglow covering a time frame of several seconds also under air. Temperature-dependent emission spectra gave information on thermally activated delayed fluorescence (TADF) and room temperature phosphorescence (RTP) while photocurrent experiments provided a deeper understanding of charge availability in the dark period, and therefore, its availability on the photocatalyst surface.

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Background: This study investigated the impact of applying the anchored teaching mode with nursing interns on the cardiac surgery intensive care unit (CSICU).

Method: A total of 110 interns were divided into a control group (taught through traditional methods) and an experimental group (taught using the anchored teaching mode). The anchored mode, emphasizing student-centered learning, included creating scenarios, identifying problems, using self-directed and collaborative learning, and evaluating outcomes.

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The use of stem cell-based treatment systems is prevalent in regenerative medicine. To enhance the regenerative capabilities of stem cells, growth factors are typically incorporated into the treatment system. Nonetheless, traditional hydrogel-encapsulated or heparinized scaffolds that bind factors have limitations.

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Synopsis of recent research by authors named "Min Ge"

  • - Min Ge's recent research focuses on developing innovative therapeutic strategies against bacterial infections, emphasizing the use of nanotechnology, cell-mimicking approaches, and novel materials to combat antibiotic resistance and enhance treatment efficacy.
  • - The research also explores the physiological impacts of surgical procedures, such as diaphragm dysfunction post-cardiac surgery, aiming to identify risk factors and improve patient recovery outcomes.
  • - Additionally, Min Ge investigates advanced materials for various applications, including the resilience of superconductors, the utilization of hybrid nanostructures for photonic applications, and new frameworks for improving tissue regeneration in medicinal use.