The genome of the Antarctic-endemic copepod, Tigriopus kingsejongensis.

Background: The Antarctic intertidal zone is continuously subjected to extremely fluctuating biotic and abiotic stressors. The West Antarctic Peninsula is the most rapidly warming region on Earth. Organisms living in Antarctic intertidal pools are therefore interesting for research into evolutionary adaptation to extreme environments and the effects of climate change.

Social and Clinical Characteristics of Immigrants with Tuberculosis in South Korea.

Purpose: To determine the social and clinical characteristics of immigrants with tuberculosis (TB) in South Korea.

Materials And Methods: The registered adult TB patients who were diagnosed and treated in Korea Medical Centers from January 2013 to December 2015 were analyzed retrospectively. A total of 105 immigrants with TB were compared to 932 native Korean TB patients.

Complete mitochondrial genome of the feather mite (Acari, Sarcoptiformes, Pterolichidae).

In this study, we determined the mitogenome sequence of (Canestrini, 1878) in the family Pterolichidae (Acari, Sarcoptiformes), which is the first complete mitogenome sequence in feather mite. The mitogenome of . is 14,069 bp in length and contains 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), 2 ribosomal RNAs (rRNAs), and a control region (CR).

Ciliary neurotrophic factor analogue aggravates CCl-induced acute hepatic injury in rats.

Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate hepatic steatosis and injury induced by carbon tetrachloride (CCl). Unexpectedly, when combined with CCl, CNTF aggravated hepatic steatosis and liver injury.

First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms.

Bathynellacea (Crustacea, Syncarida, Parabathynellidae) are subterranean aquatic crustaceans that typically inhabit freshwater interstitial spaces (e.g., groundwater) and are occasionally found in caves and even hot springs.

The pretreatment thrombocytosis may predict prognosis of patients with colorectal cancer: a systematic review and meta-analysis.

Aim: Recently, several studies have reported that thrombocytosis may be associated with the poor prognosis of colorectal cancer (CRC). Nevertheless, their conclusions were still controversial. Results & methodology: We searched PubMed, Embase, Cochrane Library and Web of Science up to April 2016.

MicroRNA-181c Ameliorates Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.

Chronic cerebral hypoperfusion (CCH) characterized by global cerebral ischemia is an important risk factor contributing to the development of dementia. MicroRNAs (miRNAs) play important roles in the cellular adaptation to long-term ischemia/hypoxia by turning off or on the expression of target genes. MiR-181c is widely expressed in the nervous system, and tripartite motif 2 (TRIM2) is one of its target genes.

The prognostic role of pretreatment platelet-to-lymphocyte ratio as predictors in patients with colorectal cancer: a meta-analysis.

Aim: This meta-analysis was designed to analyze and evaluate the prognostic role of preoperative or pretreatment platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC).

Method: We searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and WanFang Database up to April 2016.

Results: A total of 16 studies (n = 5068 participants) were included for this meta-analysis.

Pseudonotohymena antarctica n. g., n. sp. (Ciliophora, Hypotricha), a New Species from Antarctic Soil.

A new soil ciliate, Pseudonotohymena antarctica n. g., n.

Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo.

A certain nucleosomal protein-high mobility group box-1 (HMGB1)-has recently been established as a late mediator of sepsis, with a relatively wide therapeutic window for pharmacological intervention. Pelargonidin (PEL) is a well-known red pigment found in plants; it has important biological activities that are potentially beneficial for human health. In the present study, we investigated whether PEL can modulate HMGB1-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice.

Suppressive effects of three diketopiperazines from marine-derived bacteria on polyphosphate-mediated septic responses.

Diketopiperazine is a natural products found from bacteria, fungi, marine sponges, gorgonian and red algae. They are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains. The compounds in this structure class have been known to possess diverse bioactivities including antibiotic activity, anti-cancer activity, neuroprotective activity, and anti-inflammatory activity.

Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide.

Peptide drug conjugates offer a novel strategy to achieve controlled drug release. This approach avoids the clinical obstacles of non-specific toxicity and overall drug resistance of conventional cytotoxic agents, such as paclitaxel. MMP2 plays important functions in tumour proliferation and metastasis.

Suppressive effects of methylthiouracil on polyphosphate-mediated vascular inflammatory responses.

Drug repositioning is used to discover drug candidates to treat human diseases, through the application of drugs or compounds that are approved for the treatment of other diseases. This method can significantly reduce the time required and cost of discovering new drug candidates for human diseases. Previous studies have reported pro-inflammatory responses of endothelial cells to the release of polyphosphate (PolyP).

Effects of sittercise on elderly subjects' depression and sleep quality.

[Purpose] This study examined the effects of sittercise on elderly subjects' depression and sleep quality. [Subjects] The subjects of this quasi-experimental study were divided into an experimental group and a control group. [Methods] The subjects of the experimental group performed sittercise and the control group received no intervention.

Accelerated Discovery of Thermoelectric Materials: Combinatorial Facility and High-Throughput Measurement of Thermoelectric Power Factor.

A series of processes have been developed to facilitate the rapid discovery of new promising thermoelectric alloys. A novel combinatorial facility where elements are wire-fed and laser-melted was designed and constructed. Different sample compositions can be achieved by feeding different element wires at specific rates.

Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.

An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels-Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.

De novo assembly and annotation of the Antarctic copepod (Tigriopus kingsejongensis) transcriptome.

The whole transcriptome of the Antarctic copepod (Tigriopus kingsejongensis) was sequenced using Illumina RNA-seq. De novo assembly was performed with 64,785,098 raw reads using Trinity, which assembled into 81,653 contigs. TransDecoder found 38,250 candidate coding contigs which showed homology to other species by BLAST analysis.

[A new score system for prediction of death in patients with severe trauma: the value of death warning score].

Objective: To discuss a best predictive score index in predicting death in patients with severe trauma, death warning score, and to provide a simple score for clinical use.

Methods: The clinical data of 394 traumatic patients admitted to Department of Critical Care Medicine of Xi'nan Hospital of the Third Military Medical University, Daping Hospital of the Third Military Medical University, and Affiliated Hospital of Zunyi Medical College from January 2014 to December 2014 were retrospectively analyzed. The patients were divided into survival group (n = 330) and non-survival group (n = 64).

The complete mitochondrial genome of squat lobster, (Anomura, Galatheoidea, Munididae).

We determined the mitogenome sequence of (Fabricius 1793) (Anomura, Galatheoidea, Munididae), which is the first complete mitogenome sequence in the family Munididae Ahyong et al., 2010. The mitogenome of is 16 326 bp in length and contains 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), two ribosomal RNAs (rRNAs) and two control regions (CRs).

Combined Chemical Groups and Topographical Nanopattern on the Poly(ε-Caprolactone) Surface for Regulating Human Foreskin Fibroblasts Behavior.

Surface chemistry and substrate topography could contribute significantly to providing a biochemical and topographical cues for governing the fate of cells on the cell-material interface. However, the synergies between these two properties have not been exploited extensively for biomaterial design. Herein, we achieved spatial-controlled patterning of chemical groups on the poly(ε-caprolactone) (PCL) surface by elegant UV-nanoimprint lithography (UN-NIL).

Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep.

An increasing number of reports indicate that in vitro fertilization (IVF) is highly associated with long‑term side effects on embryonic and postnatal development, and can sometimes result in embryonic implant failure. While high‑throughput gene expression analysis has been used to explore the mechanisms underlying IVF-induced side effects on embryonic development, little is known about the effects of IVF on conceptus-endometrial interactions during the peri-implantation period. Using sheep as a model, we performed a comparative transcriptome analysis between in vivo (IVO; in vivo fertilized followed by further development in the uterus) and in vitro produced (IVP; IVF with further culture in the incubator) conceptuses, and the caruncular and intercaruncular areas of the ovine endometrium.

Do as I do, not as I say: Actions speak louder than words in preschoolers learning from others.

To date, no research has examined children's imitative abilities in the context of learning self-regulatory strategies from adults-especially when there is a conflict between communicative intent and later behavior. A sample of 84 4- and 5-year-olds performed a delay-of-gratification task after observing an adult perform the same task. Across four between-participants conditions, the model either did or did not state her intention to complete the task (positive vs.

Rapid flame synthesis of internal Mo(6+) doped TiO2 nanocrystals in situ decorated with highly dispersed MoO3 clusters for lithium ion storage.

The rational design of nanoheterostructured materials has attracted much attention because of its importance for developing highly efficient LIBs. Herein, we have demonstrated that internal Mo(6+) doped TiO2 nanocrystals in situ decorated with highly dispersed MoO3 clusters have been realized by a facile and rapid flame spray pyrolysis route for electrochemical energy storage. In such intriguing nanostructures, internal Mo(6+) doping can improve the conductivity of electrode materials and facilitate rapid Li(+) intercalation and ion transport and the heteroassembly of highly dispersed ultrafine MoO3 clusters with excellent electrochemical activity endows the TiO2 with extra Li(+) ion storage ability as well as incorporates Mo(6+).