Publications by authors named "Min Chul Kim"
Background: The long-term effects of early left ventricular unloading after venoarterial extracorporeal membrane oxygenation (VA-ECMO) remain unclear.
Methods: The EARLY-UNLOAD trial was a single-center, investigator-initiated, open-label, randomized clinical trial involving 116 patients with cardiogenic shock (CS) undergoing VA-ECMO. The patients were randomly assigned to undergo either early routine left ventricular unloading by transseptal left atrial cannulation within 12 hours after randomization or the conventional approach, which permitted rescue transseptal cannulation in case of an increased left ventricular afterload.
Background And Objectives: The optimal timing for complete revascularization (CR) in patients with acute myocardial infarction (AMI) and multivessel disease (MVD) remain uncertain.
Methods: This post-hoc analysis of the FRAME-AMI trial included AMI patients with MVD ( = 549). They were classified into immediate ( = 329) and staged CR ( = 220) groups.
Article Synopsis
- * While VA-ECMO is beneficial, it can cause issues like left ventricular (LV) overload due to increased retrograde arterial flow, leading to complications like pulmonary edema and arrhythmias.
- * Effective management of VA-ECMO requires LV unloading to mitigate these risks; the article discusses the timing, indications, and methods for achieving this unloading.
Article Synopsis
- - The study investigates the link between myocardial bridging (MB) and coronary vasospasm (CVS), aiming to see if CVS worsens outcomes for patients with MB over the long term.
- - Researchers included 254 patients with MB, dividing them into two groups: those with CVS (168 patients) and those without (86 patients), and examined major adverse cardiovascular events (MACEs) over an average follow-up of 8.15 years.
- - Results showed that patients with CVS experienced significantly higher rates of MACEs (35.1%) compared to those without CVS (26.7%), indicating that CVS negatively impacts the clinical outcomes of MB patients, suggesting a need for further research.
Background: Despite increasing evidence on the benefits of statin therapy for acute myocardial infarction (AMI), differential outcomes in accordance with statin intensity have not been evaluated in patients with AMI and low-density lipoprotein cholesterol (LDL-C) levels < 55 mg/dL. Therefore, this study aimed to compare the clinical outcomes of high- and moderate-intensity statin therapy in this population.
Methods: A total of 752 participants with AMI and LDL-C levels < 55 mg/dL from a Korean nationwide multicenter observational cohort (2016-2020) were included and categorized into two groups: high-intensity statin group (n = 384) and moderate-intensity statin group (n = 368).
Article Synopsis
- * Results showed that during the first week, STEMI patients had a significantly higher mortality rate (4.62%) compared to NSTEMI patients (1.79%), but this trend reversed after the second week for men and the tenth week for women.
- * The research highlights the need for further studies to develop advanced risk prediction models based on time-point mortality outcomes, as different baseline variables influenced mortality rates over time.
Introduction: Elevated low-density lipoprotein cholesterol (LDL-C) is a major residual risk factor among patients with acute coronary syndrome (ACS). In the absence of sufficient real-world evidence, this observational (noninterventional) study investigated the effectiveness and safety of evolocumab in patients with hyperlipidemia treated with evolocumab for ACS in a real-world clinical setting in Korea.
Methods: Between January 2022 and February 2023, patients from 10 hospitals in Korea who initiated evolocumab within 24 weeks of an ACS event were enrolled.
Background And Objectives: Cigarette smoking is a major risk factor for atherosclerosis. Nicotine, a crucial constituent of tobacco, contributes to atherosclerosis development and progression. However, evidence of the association between nicotine and neointima formation is limited.
View Article and Find Full Text PDFIn 10-minute speaking, N95 respirators significantly decreased SARS-CoV-2 emissions compared with no-mask wearing. However, SARS-CoV-2 was detected in the air even when wearing N95 and surgical masks in patients with high viral loads. Therefore, universal masking of infected and uninfected persons is important for preventing COVID-19 transmission via the air.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effects of clopidogrel and ticagrelor on bleeding and ischemia risks in elderly East Asian patients with diabetes and acute myocardial infarction who underwent percutaneous coronary intervention.
- It analyzed data from 838 patients over 75 years old, ultimately comparing 466 patients after matching for treatment type.
- Findings suggested that there was no significant difference in the incidence of severe bleeding or ischemia between those treated with ticagrelor versus clopidogrel, indicating the need for larger trials to find the best antiplatelet therapy for this group.
Article Synopsis
- Dyslipidemia, a key risk factor for heart attacks, has shown an increase in prevalence among Korean patients from 11.1% to 17.1% between 2011 and 2020 as this study explored trends in its management.
- Over the same period, there was a rise in statin prescriptions from 92.9% to 97.0%, with high-intensity statin use increasing dramatically and greater adoption of drugs like ezetimibe.
- Despite improvements in managing dyslipidemia, with more patients achieving lipid targets, ongoing efforts are crucial to further lower the risk of heart-related complications.*
, a traditional herb, is widely recognized for its pharmacologically active components, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid. These components render it a highly sought-after ingredient in various industries, including cosmetics and pharmaceuticals. This study aimed to enhance the production and activity of these pharmacological constituents of using the plant growth-promoting rhizobacterium HyangYak-01 during its cultivation.
View Article and Find Full Text PDFBackground: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by (SFTS virus [SFTSV]). Recently, at least 6 different genotypes of SFTSV have been identified, with genotypes A, D, and F dominant in China and B dominant in Japan and Korea. This study investigated the effect of SFTSV genotypes circulating in South Korea on disease severity, viral load, and cytokine profile.
View Article and Find Full Text PDFOptimal timing of revascularization for patients who presented with non-ST segment elevation myocardial infarction (NSTEMI) and severe left ventricular (LV) dysfunction is unclear. A total of 386 NSTEMI patients with severe LV dysfunction from the nationwide, multicenter, and prospective Korea Acute Myocardial Infarction Registry V (KAMIR-V) were enrolled. Severe LV dysfunction was defined as LV ejection fraction ≤ 35%.
View Article and Find Full Text PDFPurpose: To analyze adenoma detection rate (ADR) and related quality indicators of colonoscopy among trainees and make recommendations for appropriate colonoscopy training.
Methods: ADR and related indicators of colonoscopies performed by 3 trainees and 5 colonoscopy experts between March and November 2022 were analyzed. These indicators were analyzed in both the entire patients and the screening/surveillance group.
Article Synopsis
- * Twenty patients were enrolled, and results after 8 months showed minimal in-stent late lumen loss (0.7 mm) and complete stent strut coverage, indicating successful healing.
- * There were no adverse cardiovascular events reported within the same period, suggesting that the new stent design is safe and effective in treating coronary artery disease.
Article Synopsis
- Researchers studied 861 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) to understand how the timing of hospitalization affects mortality rates over two years.
- * They found that patients who presented late (after 12 or 24 hours) had a significantly higher risk of death compared to those who arrived early, with adjusted hazard ratios confirming this increased risk.
- * Factors such as being female, not using emergency services, and having high creatinine levels were linked to late presentation, indicating a need for better systems to minimize delays in seeking treatment.
Article Synopsis
- The study investigates the effectiveness of AI in detecting lung nodules through chest X-rays (CXR) in non-respiratory outpatient clinics, highlighting its growing importance in medical diagnostics.
- Over a two-year period, the AI software detected lung nodules in 4.4% of CXR cases, leading to subsequent evaluations that identified lung cancers and other significant conditions in many patients.
- The findings underscore the potential of AI to improve patient diagnosis and management by revealing incidental lung nodules that may have otherwise gone unnoticed, supporting its integration into routine medical practice.
Article Synopsis
- ECPR is a special medical treatment for people who have serious heart problems, but only about 29% of them leave the hospital alive.
- Researchers studied how kidney injuries, called AKI, might help predict if patients will survive or have good brain function after ECPR.
- They found that patients with AKI had much higher rates of dying in the hospital and worse brain outcomes compared to those without AKI, showing that AKI can help doctors know who might have a better or worse chance of recovering.
Usefulness of Impulse Oscillometry in Predicting the Severity of Bronchiectasis.
Tuberc Respir Dis (Seoul)
July 2024
Background: Bronchiectasis is a chronic respiratory disease that leads to airway inflammation, destruction, and airflow limitation, which reflects its severity. Impulse oscillometry (IOS) is a non-invasive method that uses sound waves to estimate lung function and airway resistance. The aim of this study was to assess the usefulness of IOS in predicting the severity of bronchiectasis.
View Article and Find Full Text PDFBackground: The Murray law-based quantitative flow ratio (μFR) is an emerging technique that requires only 1 projection of coronary angiography with similar accuracy to quantitative flow ratio (QFR). However, it has not been validated for the evaluation of noninfarct-related artery (non-IRA) in acute myocardial infarction (AMI) settings. Therefore, our study aimed to evaluate the diagnostic accuracy of μFR and the safety of deferring non-IRA lesions with μFR >0.
View Article and Find Full Text PDFObjectives: This study investigated the optimal timing for percutaneous coronary intervention (PCI) in patients with NSTEMI complicated by heart failure (HF).
Methods: In total, 762 patients with NSTEMI and HF in a multicenter, prospective registry in South Korea were classified according to the Killip classification (Killip class 2, n = 414 and Killip class 3, n = 348) and underwent early (within 24 h) and delayed (after 24 h) PCI. The primary outcome was all-cause mortality which was further analyzed with landmark analysis with two months as a cut-off.
Timing of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction with multivessel disease: Rationale and design of the OPTION-STEMI trial.
Am Heart J
July 2024
Article Synopsis
- Current guidelines suggest complete revascularization (CR) for stable patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD), but the best timing for the procedure is still unclear.
- The OPTION-STEMI trial investigates whether immediate CR during a primary angioplasty is as effective as in-hospital staged CR, using fractional flow reserve (FFR) assessments for certain lesions.
- The trial enrolled patients with significant non-infarct-related artery lesions, aiming to measure outcomes like death and myocardial infarction one year post-randomization, with results expected in mid-2025.
Intravascular imaging-guided percutaneous coronary intervention in patients with acute myocardial infarction and cardiogenic shock.
Rev Esp Cardiol (Engl Ed)
December 2024
Introduction And Objectives: There are no clinical data on the efficacy of intravascular imaging-guided percutaneous coronary intervention (PCI) compared with angiography-guided PCI in patients with acute myocardial infarction (AMI) and cardiogenic shock. The current study sought to evaluate the impact of intravascular imaging-guided PCI in patients with AMI and cardiogenic shock.
Methods: Among a total of 28 732 patients from the nationwide pooled registry of KAMIR-NIH (November, 2011 to December, 2015) and KAMIR-V (January, 2016 to June, 2020), we selected a total of 1833 patients (6.