Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush.

Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve regeneration. However, morphological assessments of retinorecipient regions are limited by the opacity of brain tissue. In this study, we used an innovative tissue cleaning technique combined with retrograde trans-synaptic viral tracing to observe changes in retinorecipient regions connected to retinal ganglion cells in mice after optic nerve injury.

Evaluation of dynamic stereopsis in intermittent exotropia patients.

Aim: To delineate the characteristics of the dynamic stereopsis test and analyze related parameters in intermittent exotropia [X(T)] patients.

Methods: Fifty-seven X(T) patients and 55 normal subjects were enrolled in this study. The normal and X(T) groups were used to test the reproducibility and reliability of the dynamic stereopsis test, and Bangerter filters with densities of 0.

Efficacy of autologous conjunctival flap on repairing the late-onset filtering bleb leakage.

Aim: To evaluate the effectiveness of autologous conjunctival flap surgery for repairing the late-onset filtering bleb leakage after trabeculectomy.

Methods: This study retrospectively reviewed 106 eyes from 106 patients with late-onset filtering bleb leakage after trabeculectomy who received autologous conjunctival flap surgery at the Zhongshan Ophthalmic Centre from 2005 to 2015. The basic information was recorded, and the interval time between trabeculectomy and autologous conjunctival flap surgery as well as related risk factors, intraocular pressure (IOP), anterior chamber depth (ACD) and best corrected visual acuity (BCVA) were analysed.

Longitudinal Cohort Study on the Incidence of Primary Open-Angle Glaucoma in Bai Chinese.

Purpose: The prevalence of primary open-angle glaucoma (POAG) in China has been reported previously, and was lower than that in white and black populations. However, the incidence of POAG in China has not been reported. Therefore, a longitudinal study was conducted to determine the 5-year cumulative incidence and predictors of POAG in China.

Phakic posterior chamber intraocular lens for unilateral high myopic amblyopia in Chinese pediatric patients.

Aim: To assess the outcomes of posterior chamber implantable collamer lens (ICL) implantation in Chinese pediatric patients with unilateral high myopic amblyopia.

Methods: Eleven eyes of 11 amblyopic patients aged 11.02±3.

Prevalence, types and awareness of glaucoma in a multi-ethnic population in rural China: the Yunnan Minority Eye Study.

Purpose: To determine the prevalence, types and awareness of glaucoma in a rural community in China and to examine possible ethnic variations.

Methods: The Yunnan Minority Eye Study was a multi-ethnic community-based eye survey using random cluster sampling strategies. 2133 Bai, 2205 Han and 2208 Yi Chinese aged 50 years or older participated in this study.

Preparation and evaluation of HPMC-based pirfenidone solution in vivo.

Context: Pirfenidone (PFD) has exhibited therapeutic potential in the treatment of cell proliferative disorders. The previously developed 0.5% water-based PFD eye drops by our team exhibited antiscarring effectiveness and ocular safety but with a limit of short half-life and poor bioavailability.

Intraocular Pressure-Lowering Potential of Subthreshold Selective Laser Trabeculoplasty in Patients with Primary Open-Angle Glaucoma.

Purpose. To compare the efficacy of subthreshold and conventional selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) in the patients with primary open-angle glaucoma (POAG). Methods.

[Progress of anti-glaucoma fixed combination formulation].

Glaucoma is a common cause of visual impairment and irreversible blindness. Medication is important in the management of glaucoma, especially in primary open-angle glaucoma. Combination drug therapy is needed because single drug therapy can not always control the intraocular pressure effectively to a safe level in glaucoma patients with higher baseline intraocular pressure.

[Preliminary study on normal values of blue-on-yellow perimetry in central thirty degrees].

Objective: To investigate the normal values and related factors of blue on yellow perimetry (BYP) in the central 30 degree.

Methods: A cross sectional study design was performed on this study. BYP was performed in a Humphery750II-i perimetry with 30-2 procedure and Fastpac strategy.

[Quality of life in patients with primary congenital glaucoma following antiglaucoma surgical management].

Objective: To evaluate the 23-item scale of Quality of Life (QOL) for patients with primary congenital glaucoma (PCG).

Methods: It was a cross-sectional study. The QOL scale specific for patients with PCG was firstly evaluated on 51 patients with PCG following antiglaucoma surgery at last followup visit (7.

[Clinical observation of trabeculectomy for primary angle closure glaucoma].

Objective: To evaluate the effect of trabeculectomy on intraocular pressure (IOP) and complications in eyes with primary angle closure glaucoma (PACG).

Methods: It was retrospective clinical study. PACG was classified as acute primary angle closure glaucoma (APACG) group and chronic primary angle closure glaucoma (CPACG) group.

[Effect of Rosiglitazone on the proliferation and the production of transforming growth factor-beta 1 in cultured human Tenon' s capsule fibroblasts].

Objective: To investigate the effect of Rosiglitazone on the proliferation and the production of transforming growth factor-beta 1 (TGF-beta 1) in cultured humans Tenon's capsule fibroblasts (HTFs).

Methods: It was a experimental study. HTFs were cultured and subcultured in vitro.

[Effect of endocyclophotocoagulation on survival of corneal grafts].

Objective: To observe the effect of semiconductor (diode) laser endocyclic-photocoagulation (ECP) on the survival of corneal grafts for patients with uncontrolled refractory glaucoma secondary to penetrating keratoplasty (PKP).

Methods: Thirty-four eyes of 34 patients with refractory glaucoma were prospectively assigned to diode laser ECP in 12 eyes, and diode laser ECP with anterior vitrectomy in 22 eyes in Zhongshan Ophthalmic Center from March 2000 to April 2004 as ECP group. Twenty-six eyes of 26 patients were underwent trans-scleral cyclophotocoagulation (TCP) as TCP group.

[The clinical study of endoscopic cyclophotocoagulation on the management of refractory glaucoma].

Objective: To evaluate the efficacy and safety of endoscopic cyclophotocoagulation (ECP) in the management of refractory glaucoma.

Methods: ECP procedures were performed on fifty-one eyes of 47 patients with refractory glaucoma by using the Microprobe (Endo Optiks, URAM E2) integrated laser endoscope system. All patients were followed-up from 6 to 16 months (mean 10.

[The experimental histopathologic changes of applying perfluoropropane to filtering surgery in rabbits].

Objective: To study the histopathologic changes of filtering blebs by subconjunctival application of perfluoropropane (C(3)F(8)) after trabeculectomy in rabbit eyes.

Methods: Twenty rabbits were randomly divided into two groups, each group consisting of 10 rabbits. Trabeculectomy with topical application of C(3)F(8) was performed on one eye and trabeculectomy alone on the other eye in first group.