NiH-catalyzed C(sp)-Si coupling of alkenes with vinyl chlorosilanes.

A novel NiH-catalyzed highly regioselective coupling of alkenes with vinyl chlorosilanes, constructing C-Si bonds, is developed. Under mild reaction conditions, a series of benzyl organosilanes with various functional groups could be accessed. Further synthetic studies illustrate that the products of this chemistry could be used as versatile precursors to prepare complicated organosilicon compounds.

Nickel-Catalyzed Reductive Cross-Coupling of Alkyl Bromides and Chlorosilanes.

A novel nickel-catalyzed highly selective reductive cross-coupling of alkyl bromides and chlorosilanes to construct the C-Si bond has been developed. Under benign reaction conditions, a series of structurally interesting organosilanes can be accessed without Ni-catalyzed isomerization. The utility of this chemistry is illustrated by further transformations of the product.

Nickel-Catalyzed Highly Selective Hydroalkenylation of Alkenyl Boronic Esters to Access Allyl Boron.

Allyl boron derivatives are valuable building blocks in the synthesis of natural products and bioactive molecules. Herein, a practical strategy of nickel-catalyzed highly selective hydroalkenylation of alkenyl boronic esters was developed. Under the mild reaction conditions, a variety of allyl boronic esters were accessed with excellent chemo- and regioselectivity.

Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.

Human-like collagen (HLC), the collagen produced using fermentation technology, has been demonstrated previously to promote wound healing. However, the healing property of HLC in gastric ulcers remains to be verified. In this study, we investigated the healing efficacy and healing mechanisms of HLC on gastric ulcers.

Pd-Catalyzed Stereoselective 1,2-Aryboration of Alkenylarenes.

The palladium-catalyzed highly regio- and diastereoselective arylboration of alkenylarenes has been developed. This chemistry afforded the benzylic boronic esters with a broad substrate scope, which are valuable synthetic intermediates for organic synthesis. The chiral anion phase-transfer strategy was designed for this transformation to realize the regio-, diastereo-, and enantioselective control of this reaction simultaneously.

Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using HO as a stoichiometric hydrogen atom donor.

A copper-catalyzed highly regio- and diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor.