Multiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell.

In eukaryotes, linear motor proteins govern intracellular transport and organization. In bacteria, where linear motors involved in spatial regulation are absent, the ParA/MinD family of ATPases organize an array of genetic- and protein-based cellular cargos. The positioning of these cargos has been independently investigated to varying degrees in several bacterial species.

Increases in CD4 T-cell count at antiretroviral therapy initiation among HIV-positive illicit drug users during a treatment-as-prevention initiative in Canada.

Background: Although treatment-as-prevention (TasP) efforts are a new cornerstone of efforts to respond to the HIV/AIDS pandemic, their effects among people who use drugs (PWUD) have not been fully evaluated. This study characterizes temporal trends in CD4 T-cell (CD4) count at ART initiation and rates of virological response among HIV-positive PWUD during a TasP initiative.

Methods: We used data on individuals initiating ART within a prospective cohort of PWUD linked to comprehensive clinical records.

Cutaneous Manifestations of Mucopolysaccharidoses.

Mucopolysaccharidoses (MPSs) are a group of inherited lysosomal storage disorders characterized by deficiencies in specific enzymes involved in the catabolism of glycosaminoglycans (GAGs). These deficiencies cause excessive metabolites to accumulate in multiple organs. There are eight different MPS disorders, contributing to the wide variation in clinical presentation.

Incidence of melanoma in organ transplant recipients in Alberta, Canada.

Background: Many studies have documented the increased risk of non-melanoma skin cancers in organ transplant recipients (OTRs). However, the incidence of melanoma is less well defined. To date, there have been no studies on the incidence of melanoma in Canadian OTRs.