Small-size temperature/high-pressure integrated sensor via flip-chip method.

Hydraulic technology with smaller sizes and higher reliability trends, including fault prediction and intelligent control, requires high-performance temperature and pressure-integrated sensors. Current designs rely on planar wafer- or chip-level integration, which is limited by pressure range, chip size, and low reliability. We propose a small-size temperature/high-pressure integrated sensor via the flip-chip technique.

G-quadruplex-hemin DNAzyme functionalized nanopipettes: Fabrication and sensing application.

Solid-nanopores/nanopipettes have the exquisite ability to reveal the changes in molecular volume due to the advantages of adjustable size, good rigidity and low noise. Herein, a new platform for sensing application was established based on G-quadruplex-hemin DNAzyme (GQH) functionalized gold-coated nanopipettes. In this method, GQH was immobilized on gold-coated nanopipette, which could be used as a catalyst for the reaction of HO with 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) to promote the conversion of ABTS to ABTS ions inside gold-coated nanopipette, and the change of transmembrane ion current could be monitored in real time.

Single gold nanowire-based nanosensor for adenosine triphosphate sensing by using in-situ surface-enhanced Raman scattering technique.

Development of new hot spots for surface enhanced Raman scattering (SERS) technique is of great significance recently. Herein, we developed a single Au nanowire (NW)-based nanosensor for adenosine triphosphate (ATP) sensing by using in-situ SERS technique. Single Au NWs, fabricated by laser-assisted pulling method and hydrofluoric acid (HF) etching process, were linked with single-stranded HS-terminated DNA.

Au-assisted polymerization of conductive poly(N-phenylglycine) as high-performance positive electrodes for asymmetric supercapacitors.

Herein, a novel conductive poly(N-phenylglycine) (PNPG) polymer was successfully prepared, byelectrochemical polymerization method (+0.75 VAg/AgCl) for 10 min, on flexible stainless-steel plate coated with a thin Au film (Au/SS) to serve as a binder-free pseudocapacitive PNPG/Au/SS electrode for energy storage devices. Compared to the electrode without Au coating, PNPG/Au/SS electrode exhibited better electrochemical performance with larger specific capacitance (495 F gat a current density of 2 A g), higher rate performance and lower resistance, which are good indications to act as a positive electrode for asymmetric supercapacitor devices.

Whole-exome sequencing reveals MYH7 p.R671C mutation in three different phenotypes of familial hypertrophic cardiomyopathy.

Familial hypertrophic cardiomyopathy (HCM) is one of the most common types of genetic heart disorder and features high genetic heterogeneity. HCM is a major cause of sudden cardiac death and also an important cause of heart failure-related disability. A pedigree with suspected familial HCM was recruited for the present study to identify genetic abnormalities.