Publications by authors named "Mima K"
Article Synopsis
- - The study examined the effect of aspirin on patients with hepatocellular carcinoma (HCC) who had liver surgery, finding that those who took aspirin showed improved outcomes compared to those who didn't.
- - Out of 1,032 patients, 87 were in the aspirin group, and results indicated significantly higher five-year recurrence-free survival (RFS) and overall survival (OS) rates for these patients.
- - The conclusion suggested that aspirin use may lead to better prognosis for HCC patients post-liver resection, highlighting the potential benefits of aspirin in this context.
Purpose: It has reported that the prevalence of frailty in patients with pancreatic cancer is 45%. The number of patients with pancreatic cancer is increasing, and within this cohort, patients often suffer from impaired activities of daily living (ADLs). This study aimed to examine the association between perioperative Barthel Index (BI) scores, a validated measure of ADLs, and survival outcomes after pancreatectomy for pancreatic cancer.
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- The study aims to assess the effectiveness and impact of minimally invasive pancreatoduodenectomy (MIPD) compared to open pancreatoduodenectomy (OPD) on patients' nutrition and immune response post-surgery.
- Out of 306 patients analyzed, MIPD showed significant benefits over OPD, including less blood loss, fewer transfusions, shorter hospital stays, and fewer complications, though it had a longer operation time.
- Despite these surgical advantages, nutritional and immunological outcomes, such as albumin levels and other indices, were similar between the two surgical methods.
Background & Aims: Epidemiologic evidence for dietary influence on colorectal cancer (CRC) risk through the gut microbiome remains limited.
Methods: Leveraging 307 men and 212 women with stool metagenomes and dietary data, we characterized and validated a sex-specific dietary pattern associated with the CRC-related gut microbial signature (CRC Microbial Dietary Score [CMDS]). We evaluated the associations of CMDS with CRC risk according to Fusobacterium nucleatum, pksEscherichia coli, and enterotoxigenic Bacteroides fragilis status in tumor tissue using Cox proportional hazards regression in the Health Professionals Follow-Up Study (1986-2018), Nurses' Health Study (1984-2020), and Nurses' Health Study II (1991-2019).
Evidence indicates that combinations of anti-EGFR antibodies and KRAS p.G12C (c.34G>T) inhibitors can be an effective treatment strategy for advanced colorectal cancer.
View Article and Find Full Text PDFBackgrounds: Several studies have indicated that BALAD score which includes the HCC tumor markers of HCC, AFP, AFP-L3%, DCP, and serum albumin and bilirubin value were good predictors of HCC patients for all treatment modalities. In this study, we aim to clarify the impact of BALAD score as the prognostic factor for HCC patients after curative surgery.
Methods: This study investigated 578 patients who underwent hepatectomy for HCC between January 2003 and May 2013.
Article Synopsis
- The text discusses the importance of accurately measuring temperature within materials for controlling dynamic processes, highlighting the limitations of existing techniques like laser-based thermography and phase-contrast imaging.
- It introduces a novel method utilizing neutron resonance absorption (NRA) to measure the temperature of elements or isotopes inside objects using a single neutron pulse from a high-power laser.
- The method was successfully demonstrated by measuring the temperature of a tantalum foil as it was heated, showing a correlation with resonance Doppler broadening and utilizing a reference silver foil for accuracy.
Article Synopsis
- - The study aimed to investigate whether having an appendectomy reduces the long-term risk of colorectal cancer, particularly for tumors associated with the bacterial species Fusobacterium nucleatum, which is linked to colorectal tumor development.
- - Using data from extensive cohort studies, researchers found that 2811 cases of colorectal cancer were recorded, with appendectomy appearing to lower the incidence of F. nucleatum-positive cancers (hazard ratio of 0.53) but not F. nucleatum-negative cancers (hazard ratio of 0.98).
- - The findings suggest that while appendectomy may reduce the risk of developing certain types of colorectal cancer (specifically F. nucleatum-positive ones), it does not significantly impact the risk for other types,
Article Synopsis
- - The study presents a case where molecular-targeted agents, like sorafenib, successfully treated a patient with unresectable hepatocellular carcinoma (HCC), leading to a significant reduction in tumor size and disappearance of lung metastases.
- - A 61-year-old male diagnosed with unresectable HCC underwent sorafenib treatment, which improved his condition, allowing for subsequent treatments like radiofrequency ablation (RFA) and transarterial chemoembolization (TACE).
- - After eight years, the patient remains alive and free from recurrence, indicating potential long-term survival through a combination of targeted therapy and multimodal treatments.
Aim: Patients with malignant tumors are prone to develop nutritional disorders. The Geriatric Nutritional Risk Index (GNRI) is a new prognostic indicator for assessing the nutritional status. This study was performed to evaluate whether the preoperative GNRI can serve as a prognostic factor in patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative surgery.
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- Research suggests that enterotoxigenic Bacteroides fragilis (ETBF) may play a role in colorectal cancer development, particularly in tumors with specific genetic markers like high-level CpG island methylator phenotype (CIMP-high) and BRAF mutations.
- The study utilized quantitative PCR to measure levels of Bacteroides fragilis and ETBF in colorectal cancer cases, finding that high levels of these bacteria are significantly linked to the presence of CIMP-high and MSI-high tumors.
- Overall, the results provide evidence that Bacteroides fragilis and ETBF may influence colorectal cancer progression through particular genetic pathways, although they do not appear to affect patient survival rates.
Outcomes of patients with frailty and metastatic cancer admitted to the intensive care unit.
Lancet Healthy Longev
December 2023
The interaction of intense laser pulses with plasma mirrors has demonstrated the ability to generate high-order harmonics, producing a bright source of extreme ultraviolet (XUV) radiation and attosecond pulses. Here, we report an unexpected transition in this process. We show that the loss of spatiotemporal coherence in the reflected high harmonics can lead to a new regime of highly efficient coherent XUV generation, with an extraordinary property where the radiation is directionally anomalous, propagating parallel to the mirror surface.
View Article and Find Full Text PDFBackground: With the rapid aging of populations worldwide, the number of vulnerable patients with liver metastasis from colorectal cancer has increased. This study aimed to examine the association between vulnerability and clinical outcomes in patients with colorectal liver metastasis (CRLM).
Methods: Consecutive 101 patients undergoing upfront hepatectomy for CRLM between 2004 and 2020 were included.
Accumulating evidence indicates an alarming increase in the incidence of early-onset cancers, which are diagnosed among adults under 50 years of age, in the colorectum, esophagus, extrahepatic bile duct, gallbladder, liver, stomach, pancreas, as well as the bone marrow (multiple myeloma), breast, head and neck, kidney, prostate, thyroid, and uterine corpus (endometrium). While the early-onset cancer studies have encompassed research on the wide variety of organs, this article focuses on research on digestive system cancers. While a minority of early-onset cancers in the digestive system are associated with cancer-predisposing high penetrance germline genetic variants, the majority of those cancers are sporadic and multifactorial.
View Article and Find Full Text PDFPurpose: To investigate the prognostic impact of RAS mutations on the Japanese Society of Hepatobiliary and Pancreatic Surgeons (JSHBPS) nomogram score in patients with colorectal cancer liver metastasis (CRLM) following hepatectomy.
Methods: We included 218 consecutive patients undergoing hepatectomy for CRLM between 2004 and 2020. The JSHBPS nomogram score was calculated using six preoperative clinical factors.
It has been reported that patients with macroscopic vascular invasion accompanying hepatocellular carcinoma have a poor prognosis. Modern molecular therapy with multitargeted tyrosine kinase inhibitors and immune checkpoint inhibitors has shown promising results in patients with metastatic hepatocellular carcinoma; however, molecular therapy is limited to patients with Child-Pugh class A disease. This review summarizes the present status of surgical therapies, including conversion hepatectomy, for patients with MVI in the developing era of novel molecular therapy.
View Article and Find Full Text PDFBackground: The number of vulnerable patients with colorectal liver metastasis (CRLM) has increased. This study aimed to clarify the relationship between perioperative activities of daily living (ADL) and clinical outcomes after hepatectomy for CRLM.
Methods: Consecutive patients undergoing resection of CRLM from 2004 to 2020 were included.
Article Synopsis
- Glycolysis is notably increased in PDAC cells, causing glucose scarcity for non-tumor cells in the tumor microenvironment (TME), which affects cell metabolism and behavior.
- Cancer-associated fibroblasts (CAFs) in this environment use lactate produced by tumor cells as an energy source, which enhances their proliferation and contributes to immunosuppression.
- The study highlights lactate dehydrogenase A (LDHA) as a poor prognostic indicator in PDAC and presents LDHA inhibition as a potential therapeutic strategy to reduce tumor growth and boost immune responses.
Article Synopsis
- Patients with bilateral lung metastases from hepatocellular carcinoma (HCC) typically receive molecular therapy, with atezolizumab and bevacizumab showing potential for long-term survival.
- A 67-year-old woman treated for HCC experienced metastases in her lungs and underwent multiple therapies, including lenvatinib, atezolizumab plus bevacizumab, and later cabozantinib and dual immune checkpoint inhibitors.
- Despite limited response from some treatments, she maintained stable disease for extended periods while preserving liver function and quality of life.
Objectives: The CD274 (programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) immune checkpoint axis is known to regulate the antitumor immune response. Evidence also supports an immunosuppressive effect of . We hypothesised that tumor CD274 overexpression might be inversely associated with abundance of in colorectal carcinoma.
View Article and Find Full Text PDFObjectives: Serine racemase (SRR) participates in serine metabolism in central nervous systems. Serine racemase is only studied in colorectal cancer, and its role in pancreatic cancer (PC) is unknown. This study aims to investigate the role of SRR in PC.
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- Statins are cholesterol-lowering drugs that inhibit HMG CoA reductase and have recently been shown to have effects on the immune system.
- In patients with resectable pancreatic cancer, statin intake was linked to better prognostic outcomes, particularly with lipophilic statins like simvastatin showing the strongest anti-proliferative effects on cancer cells.
- Simvastatin not only inhibited cancer cell growth by targeting specific protein expressions but also enhanced the effectiveness of anti-cancer immunotherapy when combined with an anti-PD-1 drug, showcasing its potential dual role in cancer treatment.
Aim: Laparoscopic and endoscopic cooperative surgery for early non-ampullary duodenum tumors (D-LECS) is now noted because of its safety and lower invasiveness. Here, we introduce two distinct approaches (antecolic and retrocolic) according to the tumor location during D-LECS.
Methods: From October 2018 to March 2022, 24 patients (25 lesions) underwent D-LECS.