HEMATOPOIETIC STEM CELL TRANSPLANTATION AND CROHN'S DISEASE: POSITION PAPER FROM THE TRANSPLANTATION COMMITTEE OF THE BRAZILIAN GROUP FOR THE STUDY OF INFLAMMATORY BOWEL DISEASES (GEDIIB).

Crohn's disease (CD) is a relapse-remitting inflammatory bowel disease that can affect any part of the digestive system. This heterogeneous disease has multiple factors that contribute to an abnormal immune response to intestinal microorganisms. Treatment is based on the use of anti-inflammatories, corticosteroids, immunosuppressants and biologic biologic agents either alone or in combination.

Magnetohydrodynamic Simulations of Self-Consistent Rotating Neutron Stars with Mixed Poloidal and Toroidal Magnetic Fields.

We perform the first magnetohydrodynamic simulations in full general relativity of self-consistent rotating neutron stars (NSs) with ultrastrong mixed poloidal and toroidal magnetic fields. The initial uniformly rotating NS models are computed assuming perfect conductivity, stationarity, and axisymmetry. Although the specific geometry of the mixed field configuration can delay or accelerate the development of various instabilities known from analytic perturbative studies, all our models finally succumb to them.

Multimessenger Binary Mergers Containing Neutron Stars: Gravitational Waves, Jets, and -Ray Bursts.

Neutron stars (NSs) are extraordinary not only because they are the densest form of matter in the visible Universe but also because they can generate magnetic fields ten orders of magnitude larger than those currently constructed on earth. The combination of extreme gravity with the enormous electromagnetic (EM) fields gives rise to spectacular phenomena like those observed on August 2017 with the merger of a binary neutron star system, an event that generated a gravitational wave (GW) signal, a short -ray burst (sGRB), and a kilonova. This event serves as the highlight so far of the era of multimessenger astronomy.

Gravitational waves from disks around spinning black holes: Simulations in full general relativity.

We present fully general-relativistic numerical evolutions of self-gravitating tori around spinning black holes with dimensionless spin / = 0.7 parallel or antiparallel to the disk angular momentum. The initial disks are unstable to the hydrodynamic Papaloizou-Pringle instability which causes them to grow persistent orbiting matter clumps.

Black hole-neutron star coalescence: Effects of the neutron star spin on jet launching and dynamical ejecta mass.

Black hole-neutron star (BHNS) mergers are thought to be sources of gravitational waves (GWs) with coincident electromagnetic (EM) counterparts. To further probe whether these systems are viable progenitors of short gamma-ray bursts (SGRBs) and kilonovas, and how one may use (the lack of) EM counterparts associated with LIGO/Virgo candidate BHNS GW events to sharpen parameter estimation, we study the impact of neutron star spin in BHNS mergers. Using dynamical spacetime magnetohydrodynamic simulations of BHNSs initially on a quasicircular orbit, we survey configurations that differ in the BH spin ( / = 0 and 0.

A novel algorithm for high compression rates focalized on electrical power quality signals.

This research proposes a high-performance algorithm for the compression rate of electrical power quality signals, using wavelet transformation. To manage the massive amount of data the telecommunications networks are constantly acquiring it is necessary to study techniques for data compression, which will save bandwidth and reduce costs extensively by avoiding having massive data storage facilities. First biorthogonal wavelet level six transform is applied, however after compression, the reconstructed signal will have a different amplitude and it will be shifted when compared to the original one.

Medical, ethical, and legal aspects of hematopoietic stem cell transplantation for Crohn's disease in Brazil.

Crohn's disease (CD) is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract. The etiology of CD is unknown; however, genetic, epigenetic, environmental, and lifestyle factors could play an essential role in the onset and establishment of the disease. CD results from immune dysregulation due to loss of the healthy symbiotic relationship between host and intestinal flora and or its antigens.

A review of hematopoietic stem cell transplantation for autoimmune diseases: multiple sclerosis, systemic sclerosis and Crohn's disease. Position paper of the Brazilian Society of Bone Marrow Transplantation.

Autoimmune diseases are an important field for the development of bone marrow transplantation, or hematopoietic stem cell transplantation. In Europe alone, almost 3000 procedures have been registered so far. The Brazilian Society for Bone Marrow Transplantation (Sociedade Brasileira de Transplantes de Medula Óssea) organized consensus meetings for the Autoimmune Diseases Group, to review the available literature on hematopoietic stem cell transplantation for autoimmune diseases, aiming to gather data that support the procedure for these patients.

Magnetohydrodynamic simulations of binary neutron star mergers in general relativity: Effects of magnetic field orientation on jet launching.

Binary neutron star mergers can be sources of gravitational waves coincident with electromagnetic counterpart emission across the spectrum. To solidify their role as multimessenger sources, we present fully 3D, general relativistic, magnetohydrodynamic simulations of highly spinning binary neutrons stars initially on quasicircular orbits that merge and undergo delayed collapse to a black hole. The binaries consist of two identical stars modeled as Γ = 2 polytropes with spin = 0.

Great Impostors: Extremely Compact, Merging Binary Neutron Stars in the Mass Gap Posing as Binary Black Holes.

Can one distinguish a binary black hole undergoing a merger from a binary neutron star if the individual compact companions have masses that fall inside the so-called mass gap of 3-5  M_{⊙}? For neutron stars, achieving such masses typically requires extreme compactness and in this work we present initial data and evolutions of binary neutron stars initially in quasiequilibrium circular orbits having a compactness C=0.336. These are the most compact, nonvacuum, quasiequilibrium binary objects that have been constructed and evolved to date, including boson stars.

Dynamically Stable Ergostars Exist: General Relativistic Models and Simulations.

We construct the first dynamically stable ergostars (equilibrium neutron stars that contain an ergoregion) for a compressible, causal equation of state. We demonstrate their stability by evolving both strict and perturbed equilibrium configurations in full general relativity for over a hundred dynamical timescales (≳30 rotational periods) and observing their stationary behavior. This stability is in contrast to earlier models which prove radially unstable to collapse.

Simulating the magnetorotational collapse of supermassive stars: Incorporating gas pressure perturbations and different rotation profiles.

Collapsing supermassive stars (SMSs) with masses ≳ 10 have long been speculated to be the seeds that can grow and become supermassive black holes (SMBHs). We previously performed general relativistic magnetohydrodynamic (GRMHD) simulations of marginally stable Γ = 4/3 polytropes uniformly rotating at the mass-shedding limit and endowed initially with a dynamically unimportant dipole magnetic field to model the direct collapse of SMSs. These configurations are supported entirely by thermal radiation pressure and reliably model SMSs with ≳ 10 .

Hematopoietic stem cell transplantation for Crohn's disease: Gaps, doubts and perspectives.

Crohn's disease (CD) is an inflammatory bowel disease that can affect any site of the digestive system. It occurs due to an immunological imbalance and is responsible for intestinal mucosal lesions and complications such as fistulas and stenoses. Treatment aims to stabilize the disease, reducing the symptoms and healing intestinal lesions.

Magnetorotational collapse of supermassive stars: Black hole formation, gravitational waves, and jets.

We perform magnetohydrodynamic simulations in full general relativity of uniformly rotating stars that are marginally unstable to collapse. These simulations model the direct collapse of supermassive stars (SMSs) to seed black holes that can grow to become the supermassive black holes at the centers of quasars and active galactic nuclei. They also crudely model the collapse of massive Population III stars to black holes, which could power a fraction of distant, long gamma-ray bursts.

GW170817, general relativistic magnetohydrodynamic simulations, and the neutron star maximum mass.

Recent numerical simulations in general relativistic magnetohydrodynamics (GRMHD) provide useful constraints for the interpretation of the GW170817 discovery. Combining the observed data with these simulations leads to a bound on the maximum mass of a cold, spherical neutron star (the TOV limit): , where is the ratio of the maximum mass of a uniformly rotating neutron star (the supramassive limit) over the maximum mass of a nonrotating star. Causality arguments allow to be as high as 1.

General relativistic magnetohydrodynamics simulations of prompt-collapse neutron star mergers: The absence of jets.

Inspiraling and merging binary neutron stars are not only important source of gravitational waves, but also promising candidates for coincident electromagnetic counterparts. These systems are thought to be progenitors of short gamma-ray bursts (sGRBs). We have shown previously that binary neutron star mergers that undergo collapse to a black hole surrounded by a magnetized accretion disk can drive magnetically powered jets.

Disks around merging binary black holes: From GW150914 to supermassive black holes.

We perform magnetohydrodynamic simulations in full general relativity of disk accretion onto nonspinning black hole binaries with mass ratio = 29/36. We survey different disk models which differ in their scale height, total size and magnetic field to quantify the robustness of previous simulations on the initial disk model. Scaling our simulations to LIGO GW150914 we find that such systems could explain possible gravitational wave and electromagnetic counterparts such as the Fermi GBM hard x-ray signal reported 0.

Gravitational wave content and stability of uniformly, rotating, triaxial neutron stars in general relativity.

Targets for ground-based gravitational wave interferometers include continuous, quasiperiodic sources of gravitational radiation, such as isolated, spinning neutron stars. In this work, we perform evolution simulations of uniformly rotating, triaxially deformed stars, the compressible analogs in general relativity of incompressible, Newtonian Jacobi ellipsoids. We investigate their stability and gravitational wave emission.

The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients.

Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods These polymorphisms were analyzed by polymerase chain reaction in 125 patients with obesity, 47 (T2DM) and 78 (Control Group). Results No significant difference was found on comparing the T2DM and Control Groups in respect to the genotypic frequencies of the polymorphisms - (II: 13.

Hematopoietic stem cell transplantation in a severe refractory Crohn's disease patient with intestinal stoma: a case report.

Background: Hematopoietic stem cell transplantation (HSCT) can be used in the treatment of patients with refractory Crohn's disease (CD) when no alternative treatment is available. However, HSCT increases the risk of infections, in particular during the aplasia of mobilization and conditioning. Moreover, intestinal stomas in CD augment the risk of morbidity in immunocompromised patients and under aplastic conditions.

Low toxicity and favorable clinical and quality of life impact after non-myeloablative autologous hematopoietic stem cell transplant in Crohn's disease.

Objective: The incidence of adverse events in myeloablative transplant protocols is high in refractory Crohn's disease; this study used low doses of cyclophosphamide. Fourteen patients were submitted to non-myeloablative autologous hematopoietic stem cell transplantation.

Results: The average number of days of anemia (hemoglobin < 10 g/dL) was 5.

Ischemic retinopathy associated with Crohn's disease.

Purpose: To report a case of a patient with ischemic retinopathy associated with Crohn's disease.

Case Report: This report presents a case of a 28-year-old female patient with Crohn's disease and sudden decrease of visual acuity in the right eye. Fluorescein angiography, optical coherence tomography, and multifocal electroretinography confirmed the clinical features of ischemic retinopathy.