Publications by authors named "Milton Nunes Moraes-Filho"
Background: The coronavirus disease (COVID-19) can cause acute respiratory distress syndrome with dyspnea, anosmia, fever, and cough. Few studies describing ocular findings have been reported. The current case series, reports the clinical findings and natural history of patients with retinal vascular occlusion after COVID-19 infection.
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- The photopic negative response (PhNR) is a specific indicator of retinal ganglion cell activity, which is important for assessing patients with Leber's hereditary optic neuropathy (LHON), a condition that can complicate standard vision tests due to lost visual acuity.!* -
- In this study, ERG recordings were taken from individuals with a specific LHON-related mutation, and the PhNR was analyzed using automated software and manual review to exclude errors from movement.!* -
- Results showed that PhNR amplitude significantly decreased in LHON patients compared to carriers and controls, indicating potential early RGC dysfunction in carriers, thus making PhNR a promising measure for future clinical research in LHON treatment.*
Purpose: To illustrate the natural history of Leber's hereditary optic neuropathy (LHON).
Design: Prospective observational case series.
Participants: The Soave-Brazil pedigree of m.
Purpose: To evaluate the safety profile of solutions containing lutein and zeaxanthin alone or associated with brilliant blue (BB).
Methods: Twenty-eight New Zealand rabbits were used to evaluate 4 concentrations of the various dye solutions: 0.5% lutein/zeaxanthin; 0.
Purpose: To investigate the pupillary light reflex (PLR) of patients with severe loss of vision due to Leber's Hereditary Optic Neuropathy (LHON) in the context of a proposed preservation of melanopsin-expressing retinal ganglion cells (mRGCs).
Methods: Ten LHON patients (7 males; 51.6 ± 14.
Posterior hyaloid detachment and internal limiting membrane peeling assisted by anthocyanins from acai fruit (Euterpe oleracea) and 10 other natural vital dyes: experimental study in cadaveric eyes.
Retina
January 2013
Purpose: The purpose of this study was to determine whether natural dyes facilitate posterior hyaloid detachment (posterior vitreous detachment [PVD]) and retinal internal limiting membrane (ILM) peeling in human eyes.
Methods: Open-sky vitrectomy with posterior hyaloid and ILM removal was performed in 86 human cadaveric eyes. After core vitrectomy, 11 different dyes were injected into the vitreous cavity to aid hyaloid detachment and ILM removal.
Purpose: To evaluate the in vivo and in vitro toxicity of sunitinib malate, a multikinase inhibitor molecule.
Design: Experimental, Prospective, Controlled.
Methods: Human retinal pigment epithelial (ARPE-19) and human umbilical vein endothelialcells (HUVECS) were used in a culture toxicity test and exposed to different concentrations of sunitinib malate for 18 hours.
Aims: Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed.
View Article and Find Full Text PDFThis is the first study to evaluate the prevalence of headache and migraine among Tupiniquim Brazilian natives. A high prevalence of headache was found and the most prevalent headache was migraine. Women were more commonly affected than men.
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