Publications by authors named "Milton A"

Introduction: is an emerging food-borne pathogen with zoonotic potential which is often under-reported due to misidentifications.

Materials And Methods: The current study identified from retail fish sold in market which was confirmed by phenotypic (colorless colonies on Xylose-Rhamnose-Melibiose MacConkey Agar), genotypic (dual target uniplex PCR-based detection) and genomic methods (CheckM analysis). In this paper we report the phenotypic characters of the isolate and genomic features such as resistome, virulome and mobilome followed by O and H antigen based typing and comparative phylogenomics using various tools (RAST, RGI v6.

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Purpose: Health-related social needs (HRSNs) are associated with adverse cancer health outcomes. We assessed the processes for screening and responding to both HRSNs and financial distress and described the methods used across National Cancer Institute Community Oncology Research Program (NCORP) practices.

Methods: The NCORP 2022 Landscape Assessment survey focused on services to screen for and respond to HRSNs and financial distress within a national network of community oncology practices.

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Objective: Studies conducted prior to COVID-19 suggested that racial and ethnic disparities in mammographic screening have reduced over time. COVID-19 has had devastating effects on racial and ethnic minority populations, resulting in delays in preventive screening. Our purpose was to determine if racial and ethnic minority groups were less likely to receive mammographic screening during the COVID-19 pandemic.

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(Mithun) and (yak) are crucial to the culture, food security, and economy of Southeast Asia, especially in India and China, respectively. Their genetic closeness to (indicine cattle) and (taurine cattle) necessitates precise methods for meat origin authentication. This study introduces a DNA-based technique to distinguish Mithun and yak species using the alkaline lysis (AL) protocol for DNA extraction, followed by species-specific polymerase chain reaction (PCR) to amplify unique mitochondrial D-loop regions, yielding 489 bp and 422 bp amplicons, respectively.

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Objective: This study describes the implementation of a 6-week nutrition and culinary education curriculum at a transitional housing facility for single mothers in Tulsa, Oklahoma, United States.

Methods: Using a novel, trauma-informed approach to nutrition education, we delivered the Around the Table: Nourishing Families curriculum across three, small group cohorts (n = 15) over a period of 2 years. Lessons emphasized small group dialogue and group-directed learning on the topics of toxic stress, food as nourishment and family resilience combined with hands-on recipe preparation by the group.

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Background: Digital wearable devices, worn on or close to the body, have potential for passively detecting mental and physical health symptoms among people with severe mental illness (SMI); however, the roles of consumer-grade devices are not well understood.

Objective: This study aims to examine the utility of data from consumer-grade, digital, wearable devices (including smartphones or wrist-worn devices) for remotely monitoring or predicting changes in mental or physical health among adults with schizophrenia or bipolar disorder. Studies were included that passively collected physiological data (including sleep duration, heart rate, sleep and wake patterns, or physical activity) for at least 3 days.

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and are recognized as emerging pathogens with zoonotic potential. Despite their increasing importance, there is a paucity of data on the cytotoxicity of these two pathogens. Therefore, in the present study, we investigated the cytotoxic potentials of the cell-free supernatants from 10 and 15 isolates for their cytotoxic effects on four different cell lines (CHO, Vero, HeLa, and MDCK).

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Article Synopsis
  • The Western Ghat region of Kerala has rich biodiversity that supports tick populations, which carry the Kyasanur Forest Disease virus (KFDV), known to cause hemorrhagic fever or "monkey fever."
  • Tick infestations are common in local livestock, as these animals often graze in nearby forests, leading to increased risk of farmers contracting tick-borne diseases.
  • While KFDV is widespread, data on other related viruses like CCHFV and GANV is limited, though a small percentage of livestock showed CCHFV exposure, indicating the need for further research and surveillance to identify disease hotspots.
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Breast cancer is a major cause of morbidity and mortality in women. In breast cancer screening, Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) has shown promise as a technique, providing enhanced temporal patterns of breast tissues. This study proposes an enhanced segmentation method for identifying breast lesions.

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  • This study focuses on the genomics of zoonotic foodborne pathogens originating from pigs, highlighting the limited knowledge in this area.
  • Researchers analyzed pig-derived genomes alongside existing data to explore their genetic features, virulence, resistance, and phylogenomic relationships.
  • Findings show that most pig isolates belong to a specific clonal complex, with a significant presence of antibiotic resistance genes and a diverse set of mobile genetic elements, indicating potential public health implications.
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  • Digital health interventions (DHIs) could offer low-cost, scalable improvements in care for adults with schizophrenia, with a review assessing their efficacy through randomized controlled trials (RCTs) that incorporate human support.
  • A systematic search identified 26 RCTs involving 2,481 participants, finding no significant improvements in psychosis symptoms or overall health outcomes, though there was a notable trend towards benefits in social cognition and quality of life.
  • The study concludes that while DHIs are feasible and may improve health outcomes with human support, more high-quality research is needed to explore their long-term effectiveness and integration of technology in clinical practice.
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  • X chromosome inactivation (XCI) is an epigenetic phenomenon where one X chromosome in females is silenced, differing between eutherian (random silencing) and marsupial mammals (always paternal silencing).
  • In eutherians, the inactive X shows high DNA methylation at key sites, while marsupials have lower methylation levels on the paternal X.
  • The study focused on the tammar wallaby's X chromosome during sperm development, finding that the paternal X has a DNA methylation profile similar to the inactive X in female tissues, suggesting it may serve as an imprint for paternal XCI in marsupials.
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Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds.

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Purpose Of Review: Schizophrenia spectrum disorders (SDD) are characterized by a complex array of psychosis symptoms, and typically require ongoing and long-term support, including pharmacological and nonpharmacological management. Digital mental health interventions (DMHIs) have been suggested as a novel therapeutic approach to enable low-cost, scalable improvements in quality of care for adults living with SSD. However, the types and role of human involvement and support within DMHIs is currently unknown.

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  • Ferroptosis is a key form of cell death linked to various diseases, characterized by excessive peroxidation of fatty acids in cell membranes, which causes the cell to rupture.
  • This process is influenced by iron and redox balance within cells but can also be targeted for pharmacological treatments, making ferroptosis-related proteins potential candidates for new therapies.
  • A research consortium in Germany, along with leading experts, aims to review the mechanisms, significance, and methodologies related to ferroptosis to promote further research and potential new treatments for diseases affected by this process.
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Objective: There are limited data about food insecurity within the cancer screening setting. To inform the potential need for food insecurity interventions, our study evaluated the association between food security and mammographic screening among eligible participants.

Methods: Female respondents aged 40 to 74 years in the 2019 National Health Interview Survey without history of breast cancer were included.

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A case is described in which appendicitis presented in a 73-year-old woman the day after a colonoscopy. Possible mechanisms for appendicitis aggravated by colonoscopy include barotrauma, irritation by residual glutaraldehyde type solution used for cleaning the endoscope, fecalith, and/or appendicolith being pushed into the orifice of the appendix by insufflation during the colonoscopy. This rare complication is likely most often unavoidable due to the pressure required to properly visualize the colon (which typically ranges from 9 to 57 mmHg) and the manipulation required to visualize and cannulate the ileocecal valve.

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Background: While a core aim of early intervention psychosis services (EIPS) is to prevent hospitalisation, many with a first episode of psychosis (FEP) will require inpatient care. We explored young people's (YP) and their carers' hospitalisation experiences prior to and during EIPS engagement and how factors across these services influenced these experiences.

Methods: Using purposive sampling, we recruited twenty-seven YP, all of whom had been involved with the hospital system at some stage, and twelve support persons (parents and partners of YP) from state and federally funded EIPS in Australia with different models of care and integration with secondary mental health care.

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In response to the mass adoption and extensive usage of Internet-enabled devices across the world, a major review published in this journal in 2019 examined the impact of Internet on human cognition, discussing the concepts and ideas behind the "online brain". Since then, the online world has become further entwined with the fabric of society, and the extent to which we use such technologies has continued to grow. Furthermore, the research evidence on the ways in which Internet usage affects the human mind has advanced considerably.

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Background: Crisis Resolution Teams (CRTs) offer home-based care for people in mental health crisis, as an alternative to hospital admission. The success of CRTs in England has been variable. In response to this, the CRT Optimization and RElapse prevention (CORE) study developed and trialled a 12-month Service Improvement Programme (SIP) based on a fidelity model.

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Zinc-ion batteries (ZIBs) are promising candidates for safe energy storage applications. However, undesirable parasitic reactions such as dendrite growth, gas evaluation, anode corrosion, and structural damage to the cathode under an acidic microenvironment severely affected cell performance. To resolve these issues, an MXene entrapped in an ionic liquid semi-solid gel polymer electrolyte (GPE) composite was explored.

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Objective: This study aimed to solve the debate over the role and extent of neck dissection to treat any occult nodal metastasis in patients undergoing salvage laryngectomy for recurrent and/or residual squamous cell carcinoma of larynx.

Methods: This was a retrospective study over a time frame of 6 years (2016-2022) of 74 patients who underwent bilateral neck dissection and salvage laryngectomy for recurrent or persistent disease with N0 neck. We calculated the incidence of occult nodal metastasis in ipsilateral and contralateral neck.

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Article Synopsis
  • * A new diagnostic method called single-tube nested PCR (STN-PCR) has been developed to detect the virus, using specially designed primers for better sensitivity and lower contamination risks.
  • * The STN-PCR assay showed a 100-fold improvement in detecting the virus compared to traditional methods, successfully identifying 100 copies of ASFV genomic DNA, and demonstrated 100% specificity with strong agreement with existing assays.
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