Synthesis and Characterization of Mesoporous Materials Functionalized with Phosphinic Acid Ligand and Their Capability to Remove Cd(II).

This article presents a study of cadmium removal from nitrate medium using adsorption in calcined mesoporous silica (MCM-C), mesoporous silica doped (MCM_DIOPA), and calcined and impregnated mesoporous silica (MCM@DIOPA), with diisooctylphosphinic acid (DIOPA). The sorbents were synthesized via a sol-gel method. Several characterization techniques, such as XRD, FTIR spectroscopy, N sorption and elemental analysis, have been used to determine the main structural, textural, and chemical properties of prepared sorbents.

Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma.

Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to inhibit XPO1. In primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin's lymphoma (cHL), the XPO1 gene may be mutated on one nucleotide and encodes the mutant XPO1 .

Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma.

The gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent point mutation (NM_003400, chr2:g61718472C>T) resulting in the E571K substitution within the hydrophobic groove of the protein, the site of cargo binding. We investigated the impact of the mutation using PMBL/cHL cells having various statuses and CRISPR-Cas9-edited cells in which the E571K mutation was either introduced or knocked-out.

Lanthanide recovery by silica-Cyanex 272 material immobilized in alginate matrix.

Mesoporous silica impregnate with Cyanex 272 (bis/2,4,4-trimethylpentyl/phosphinic acid) extractant was immobilized into an alginate matrix to obtain a composite sorbent easy to use and applicable in fixed-bed column continuous systems. The sorption efficiency of this material was tested for the recovery of Eu(III) ions from aqueous solutions in batch and continuous mode. The competition among rare earths ions (europium, lanthanum, and lutetium) and among rare earths and calcium or sodium ions was investigated.

Removal of Zinc from Aqueous Solutions Using Lamellar Double Hydroxide Materials Impregnated with Cyanex 272: Characterization and Sorption Studies.

Removal of heavy metals from wastewater is mandatory in order to avoid water pollution of natural reservoirs. In the present study, layered double hydroxide (LDH) materials were evaluated for removal of zinc from aqueous solutions. Materials thus prepared were impregnated with cyanex 272 using the dry method.

Boron Removal from Aqueous Solutions by Using a Novel Alginate-Based Sorbent: Comparison with AlO Particles.

Boron removal was evaluated in the present work by using calcium alginate beads (CA) and a novel composite based on alginate-alumina (CAAl) as sorbents in a batch system. The effects of different parameters such as pH, temperature, contact time, and composition of alginate (at different concentrations of guluronic and mannuronic acids) on boron sorption were investigated. The results confirm that calcium alginate beads (CA) exhibited a better adsorption capacity in a slightly basic medium, and the composite alginate-alumina (CAAl) exhibited improved boron removal at neutral pH.

STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma.

Primary mediastinal B-cell lymphoma (PMBL) is a distinct B-cell lymphoma subtype with unique clinicopathological and molecular features. PMBL cells are characterised by several genetic abnormalities that conduct to the constitutive activation of the Janus kinase 2/signal transducer and activator of transcription 6 (JAK2/STAT6) signalling pathway. Among recurrent genetic changes in PMBL, we previously reported that the XPO1 gene encoding exportin 1 that controls the nuclear export of cargo proteins and RNAs, is mutated (p.

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.

Mantle cell lymphoma (MCL) is a hematologic neoplasm characterised by the t(11;14)(q13;q32) translocation leading to aberrant cyclin D1 expression. The cell functions of cyclin D1 depend on its partners and/or subcellular distribution, resulting in different oncogenic properties. We observed the accumulation of cyclin D1 in the cytoplasm of a subset of MCL cell lines and primary cells.

A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.

Background: Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alterations are common in MCL cells such as SOX11 expression, mutations of ATM and/or TP53 genes, activation of the NF-κB signaling pathway and NOTCH receptors.

Application of rodes software to experimental biokinetic data for dose assessment in mice and rats.

H Miloudi, M Locatelli, G Autret, D Balvay, A Desbrée, E Blanchardon, J M Bertho: application of RODES software to experimental biokinetic data for dose assessment in mice and rats. In support of experimental studies of chronic, long-term contamination in rodents, voxel-based computer models were built representing adult mice and juvenile, adult and elderly rats of both sexes. RODES software was created to calculate absorbed radiation doses to organs with these specific anatomical models.

XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.

Many recent publications highlight the large role of the pivotal eukaryotic nuclear export protein exportin-1 (XPO1) in the oncogenesis of several malignancies, and there is emerging evidence that XPO1 inhibition is a key target against cancer. The clinical validation of the pharmacological inhibition of XPO1 was recently achieved with the development of the selective inhibitor of nuclear export compounds, displaying an interesting anti-tumor activity in patients with massive pre-treated hematological malignancies. Recent reports have shown molecular alterations in the gene encoding XPO1 and showed a mutation hotspot (E571K) in the following two hematological malignancies with similar phenotypes and natural histories: primary mediastinal diffuse large B cell lymphoma and classical Hodgkin's lymphoma.

RODES software for dose assessment of rats and mice contaminated with radionuclides.

In order to support animal experiments of chronic radionuclides intake with realistic dosimetry, voxel-based three-dimensional computer models of mice and rats of both sexes and three ages were built from magnetic resonance imaging. Radiation transport of mono-energetic photons of 11 energies and electrons of 7 energies was simulated with MCNPX 2.6c to assess specific absorbed fractions (SAFs) of energy emitted from 13 source regions and absorbed in 28 target regions.